ES433901A1 - Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 signifies a hydrogen, chlorine or bromine atom; R3 means a carbalkoxy group, R4 and R5 which may be the same or different, represent hydrogen atoms, straight-chain or branched alcohol radicals with 1 to 5 carbon atoms, which may be substituted by one or two hydroxy groups, alkenyl radicals with 2 to 4 carbon atoms, cycloalcohyl radicals with 5 to 7 carbon atoms, optionally substituted with one or two hydroxy groups, benzyl, morpholinocarbonylmethyl groups or together with the nitrogen atom, signify a pyrrolidine ring, piperidine, hexame tilenamine, morpholine, N- methyl piperazine or camfidine, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reacted, **(See formula)** wherein R1, R2, R4 and R5 are as initially defined and B represents a carboxyl group or one of its functional derivatives, with a compound of the general formula III, R10-C (III) where R10 represents a lower alcohol radical and C represents a hydroxyl group or a halogen atom, and a compound of the general formula I obtained, where R1 represents a hydrogen atom and R2, R3, R4 and R5 with the exception of radicals containing a hydrogen atom capable of reacting, are as initially defined, are acylated if desired subsequently, and/or a compound obtained from the general formula I is transformed if desired into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)