ES433898A1 - Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES433898A1
ES433898A1 ES433898A ES433898A ES433898A1 ES 433898 A1 ES433898 A1 ES 433898A1 ES 433898 A ES433898 A ES 433898A ES 433898 A ES433898 A ES 433898A ES 433898 A1 ES433898 A1 ES 433898A1
Authority
ES
Spain
Prior art keywords
general formula
formula
compound
hydrogen atom
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES433898A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742405322 external-priority patent/DE2405322A1/en
Priority claimed from ES424432A external-priority patent/ES424432A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to ES433898A priority Critical patent/ES433898A1/en
Publication of ES433898A1 publication Critical patent/ES433898A1/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 signifies a hydrogen, chlorine or bromine atom; R3 signifies a fluorine atom, a straight or branched chain C 1 -C 4 alcohol radical, a trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkali, acetyl group, as well as the aminomethyl group of the formula **(See formula)** where R6 and R7, which may be the same or different, represent alcoholic, cycloalkyl or hydroxy-chloalkyl groups or together with the nitrogen atom a pyrrolidine, piperidine or morpholine ring, R4 represents a hydrogen atom or an alcohol radical with 1 to 3 carbon atoms, R5 means an alcohol radical with 1 to 3 carbon atoms or the cyclohexyl group; or R4 and R5 signify, together with the nitrogen atom, the morpholino or piperidino radical, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of general formula II is reacted, **(See formula)** wherein R1, R2 and R3 are as initially defined, with an amide of general formula III, **(See formula)** wherein R4 and R5 are as initially defined, and a compound of the general formula I obtained according to the procedure in which R3 represents a cyano group, is transformed by partial hydrolysis into the corresponding carbamoyl compound of the general formula I, and/or a compound obtained of the general formula I, in which it represents a hydrogen atom and R2, R3, R4 and R5 with the exception of the radicals containing a hydrogen atom capable of reacting, are as initially defined, it is acylated if desired subsequently, and/or a compound obtained of the general formula I is transformed if desired into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
ES433898A 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) Expired ES433898A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES433898A ES433898A1 (en) 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19742405322 DE2405322A1 (en) 1974-02-05 1974-02-05 NEW METHODS FOR MANUFACTURING BENZYLAMINES
ES424432A ES424432A1 (en) 1973-04-13 1974-03-20 Substituted aminobenzylamines
ES433898A ES433898A1 (en) 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES433898A1 true ES433898A1 (en) 1976-11-16

Family

ID=27185764

Family Applications (1)

Application Number Title Priority Date Filing Date
ES433898A Expired ES433898A1 (en) 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES433898A1 (en)

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