MX3103E - PROCEDURE TO PREPARE BENCIL AMINAS - Google Patents
PROCEDURE TO PREPARE BENCIL AMINASInfo
- Publication number
- MX3103E MX3103E MX003606U MX360673U MX3103E MX 3103 E MX3103 E MX 3103E MX 003606 U MX003606 U MX 003606U MX 360673 U MX360673 U MX 360673U MX 3103 E MX3103 E MX 3103E
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- signifies
- see
- general formula
- radical
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a la preparación de bencilaminas de la fórmula general I: (VER FIGURA) en la que Hal significa un átomo de cloro o de bromo, R1 significa un átomo de hidrógeno, cloro o bromo, R2 significa el radical morfolinocarbonilmetilo, un radical alcohílo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidróxilo, o un grupo de la fórmula: (VER FIGURA) en donde R3 significa un átomo de hidrógeno, un grupo hidroxi o un grupo alcohilo con 1 a 4 átomos de carbono, n significa los números 0, 1 ó 2 y los dos radicales A y B significan átomos de hidrógeno o conjuntamente el grupo ( VER FIGURA) en donde R5 representa un átomo de hidrógeno o un radical alcohílo inferior con 1 ó 2 átomos de carbono y m significa los números 1 ó 2, R4 significa un radical alcohilo de cadena recta o ramificada con 1 a 4 átomos de carbono, un radical alquenilo con 2 a 4 átomos de carbono, un radical cicloalquilo con 3 o 4 átomos de carbono o también un átomo de hidrógeno, caso de que R3 no represente ningún átomo de hidrógeno, o R2 rapresenta un radical alcohilo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidróxilo, y 1 significan los números 1 ó 2, encontrándose un átomo de halógeno en posición 2, así como de sus sales por adición de ácido fisiológicamente compatibles con ácidos orgánicos o inorgánicos, caracterizado porque se hace reaccionar un fenol de la fórmula general II (VER FIGURA), en la que R1, Hal son como se ha definido inicialmente, encontrándose uno de los radicales Hal en posición 2 del compuesto de la fórmula general VIII, con formaldehído o paraformaldehído y con una amina de la fórmula general III, (VER FIGURA) en la que R2 y R4 son como se han definido inicialmente, en un disolvente y a temperatura de 0 a 100°C, y un compuesto de la fórmula general I, obtenido de acuerdo con el procedimiento es transformado en caso deseado a continuación en sus sales fisiológicamente compatibles con ácidos orgánicos o inorgánicos.The present invention relates to the preparation of benzylamines of the general formula I: (SEE FIGURE) in which Hal signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms, optionally substituted with 1 to 3 hydroxyl groups, or a group of the formula: (SEE FIGURE) where R3 means a hydrogen atom, a hydroxy group or an alcohol group with 1 to 4 carbon atoms, n means the numbers 0, 1 or 2 and the two radicals A and B mean hydrogen atoms or together the group (SEE FIGURE) where R5 represents a hydrogen atom or a lower alcohol radical with 1 or 2 carbon atoms and m signifies the numbers 1 or 2, R4 signifies a straight or branched chain alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms, a cycloalkyl radical with 3 or 4 carbon atoms or also an atom of hydrogen, in case R3 does not represent any hydrogen atom, or R2 represents a branched alcohol radical with 3 to 5 carbon atoms, possibly substituted with 1 to 3 hydroxyl groups, and 1 signify the numbers 1 or 2, being a halogen atom in position 2, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a phenol of the general formula II is reacted (SEE FIGURE), in which R1, Hal are as initially defined , one of the radicals Hal being in position 2 of the compound of the general formula VIII, with formaldehyde or paraformaldehyde and with an amine of the general formula III, (SEE FIGURE) in which R2 and R4 are as initially defined, in a solvent and at a temperature from 0 to 100 ° C, and a compound of the general formula I, obtained according to the procedure, is subsequently transformed, if desired, into its physiologically compatible salts with ac organic or inorganic gone.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722251891 DE2251891C3 (en) | 1972-10-23 | Benzylamines, their physiologically acceptable salts, processes for their preparation and pharmaceuticals containing them | |
| DE19732320967 DE2320967C3 (en) | 1973-04-26 | New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them | |
| DE2346743A DE2346743C3 (en) | 1972-10-23 | 1973-09-17 | 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3103E true MX3103E (en) | 1980-04-10 |
Family
ID=27184785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX003606U MX3103E (en) | 1972-10-23 | 1973-10-23 | PROCEDURE TO PREPARE BENCIL AMINAS |
Country Status (7)
| Country | Link |
|---|---|
| AT (2) | ATA89375A (en) |
| DE (1) | DE2346743C3 (en) |
| ES (3) | ES423972A1 (en) |
| MX (1) | MX3103E (en) |
| PH (1) | PH13986A (en) |
| PL (2) | PL96274B1 (en) |
| SU (3) | SU520033A3 (en) |
-
1973
- 1973-09-17 DE DE2346743A patent/DE2346743C3/en not_active Expired
- 1973-10-17 AT AT89375*A patent/ATA89375A/en not_active IP Right Cessation
- 1973-10-17 AT AT89075*A patent/ATA89075A/en not_active IP Right Cessation
- 1973-10-22 PL PL1973176692A patent/PL96274B1/en unknown
- 1973-10-22 PH PH15134A patent/PH13986A/en unknown
- 1973-10-22 PL PL1973176689A patent/PL91886B1/en unknown
- 1973-10-23 MX MX003606U patent/MX3103E/en unknown
-
1974
- 1974-03-06 ES ES423972A patent/ES423972A1/en not_active Expired
- 1974-03-06 ES ES423969A patent/ES423969A1/en not_active Expired
- 1974-03-06 ES ES74423971A patent/ES423971A1/en not_active Expired
- 1974-10-10 SU SU2065438A patent/SU520033A3/en active
- 1974-10-10 SU SU2065408A patent/SU519123A3/en active
- 1974-10-10 SU SU2065436A patent/SU517248A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| PL96274B1 (en) | 1977-12-31 |
| DE2346743B2 (en) | 1978-11-09 |
| ES423972A1 (en) | 1976-06-16 |
| PL91886B1 (en) | 1977-03-31 |
| SU519123A3 (en) | 1976-06-25 |
| ES423971A1 (en) | 1976-06-16 |
| SU520033A3 (en) | 1976-06-30 |
| DE2346743C3 (en) | 1979-07-12 |
| DE2346743A1 (en) | 1975-04-03 |
| ATA89075A (en) | 1975-07-15 |
| PH13986A (en) | 1980-11-20 |
| ATA89375A (en) | 1975-07-15 |
| ES423969A1 (en) | 1976-06-16 |
| SU517248A3 (en) | 1976-06-05 |
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