GR21104B - IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS. - Google Patents

IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS.

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Publication number
GR21104B
GR21104B GR580121104A GR580121104A GR21104B GR 21104 B GR21104 B GR 21104B GR 580121104 A GR580121104 A GR 580121104A GR 580121104 A GR580121104 A GR 580121104A GR 21104 B GR21104 B GR 21104B
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GR
Greece
Prior art keywords
substituted
formula
type
industrial manufacture
pharmacological compounds
Prior art date
Application number
GR580121104A
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Greek (el)
Original Assignee
Lepetit S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lepetit S.P.A. filed Critical Lepetit S.P.A.
Priority to GR580121104A priority Critical patent/GR21104B/en
Publication of GR21104B publication Critical patent/GR21104B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

έθοδος παρασκευής 3,3-δις υποκατασταθείσης 2-αζετιδινόννης του τύπου: (ΤΥΠΟΣ Ι) ένθα R και R1, είναι τα ίδια ή διάαφορα και παριστώσιν εν κατώτερον γραμμικόν ή διακλαδωθέν, κεκορεσμένον ή μη κεκορεσμένον αλκύλιον το οποίονδύναται να υποκατασταθή υπό αλογόνου ή κατ' επιλογήν υποκατασταθείσης ρίζης αρυλίου, αραλκυλίου, κυκλοαλκυλίου, ή κυκλοαλκενυλίου ή αντικατασταθείσης ρίζηςαμινοαλκυλίου και R2 είναι υδρογόνον ή μία κατωτέρα ρίζα αλκυλίου η οποία περιλαμβάνει ενέργειαν αντιδράσεως 1 mole αμινοεστέρος του τύπου: (ΤΥΠΟΣ ΙΙ) μετά 2-4 mole αλογονιδίου αλκυλομαγνησίου εντός ενός ανύδρου οργανικού διαλύτου, όπως η βενζόλη, αιθυλαιθήρ ή μίγματα αυτών, εις θερμοκρασίαν μεταξύ 0 και 5 βαθμούς και επί 1-8 ώρας.Method of preparing 3,3-bis substituted 2-azetidinone of the formula: (TYPE I) wherein R and R 1 are the same or different and represented by a lower linear or branched, saturated or unsaturated alkyl which can be substituted by halogen or optionally substituted by a or a lower alkyl radical comprising a reaction activity of 1 mole amino ester of the formula: (TYPE II) then 2-4 moles of alkyl magnesium halide in an anhydrous organic solvent, such as benzene, ethyl ether or mixtures thereof, at a temperature between 0 and 5 degrees and for 1-8 hours.

GR580121104A 1958-05-03 1958-05-03 IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS. GR21104B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR580121104A GR21104B (en) 1958-05-03 1958-05-03 IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR580121104A GR21104B (en) 1958-05-03 1958-05-03 IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS.

Publications (1)

Publication Number Publication Date
GR21104B true GR21104B (en) 1960-07-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
GR580121104A GR21104B (en) 1958-05-03 1958-05-03 IMPROVEMENTS IN THE METHOD OF INDUSTRIAL MANUFACTURE OF PHARMACOLOGICAL COMPOUNDS.

Country Status (1)

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GR (1) GR21104B (en)

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