MX3141E - PROCEDURE TO PREPARE BENCIL AMINAS - Google Patents
PROCEDURE TO PREPARE BENCIL AMINASInfo
- Publication number
- MX3141E MX3141E MX360873U MX360873U MX3141E MX 3141 E MX3141 E MX 3141E MX 360873 U MX360873 U MX 360873U MX 360873 U MX360873 U MX 360873U MX 3141 E MX3141 E MX 3141E
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- radical
- group
- signifies
- hydrogen atom
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de bencilaminas de la fórmula general I, (VER FIGURA), en la que Ha1 significa un átomo de cloro o de bromo, R1 significa un átomo de hidrógeno, cloro o bromo, R2 significa el radical morfolinocarbonilmetilo, un radical alcohilo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidroxilo, o un grupo de la fórmula (VER FIGURA), en donde R3 significa un átomo de hidrógeno, un grupo hidroxi o un grupo alcohilo con 1 a 4 átomos de carbono, n significa los números 0, 1 ó 2 y los dos radicales A y B significan átomos de hidrógeno o conjuntamente el grupo (VER FIGURA), en donde R5 represente un átomo de hidrógeno o un radical alcohilo inferior con 1 o 2 átomos de carbono y m significa los números 1 ó 2, R4 significa un radical alcohilo de cadena recta o ramificada con 1 a 4 átomos de carbono, un radical alquenilo con 2 a 4 átomos de carbono, un radical cicloalcohilo con 3 ó 4 átomos de carbono o también un átomo de hidrógeno, caso que R3 no represente ningún átomo de hidrógeno o R2 represente un radical alcohilo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidroxilo; y 1 significa los números 1 ó 2, así como de sus sales por adición de ácido fisiológicamente compatibles con ácidos orgánicos o inorgánicos, caracterizado porque de un compuesto de fórmula general II (VER FIGURA), en la que R1 , R2, Ha1 y 1 son como se a definido inicialmente,X representa un radical protector para un grupo amino, por ejemplo un grupo acilo o posee los significados inicialmente citados para R4, e Y representa un radical protector y un grupo hidroxilo por ejemplo un grupo acilo, alquilo arilo o en el caso en que X representa un grupo protector par un grupo amino, representa un átomo de hidrógeno, se separa uno o dos radicales y protectores en un disolvente por medio de hidrólisis a temperaturas de entre 0°C y la temperatura de ebullición del disolvente utilizado, por ejemplo a temperaturas de entre 0 y 100°C y un compuesto de la fórmula general I, obtenido de acuerdo con el procedimiento es trasnformado en caso deseado a continuación de sus sales fisiológicamente compatibles con ácidos orgánicos o inorgánicos.The present invention relates to a process for the preparation of benzylamines of the general formula I, (SEE FIGURE), in which Ha1 signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms, optionally substituted with 1 to 3 hydroxyl groups, or a group of the formula (SEE FIGURE), where R3 signifies a hydrogen atom, a hydroxy group or a group alcohol with 1 to 4 carbon atoms, n means the numbers 0, 1 or 2 and the two radicals A and B mean hydrogen atoms or together the group (SEE FIGURE), where R5 represents a hydrogen atom or an alcohol radical lower with 1 or 2 carbon atoms and m signifies the numbers 1 or 2, R4 signifies a straight chain or branched alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms, a cycloalcohyl radical with 3 or 4 carbon atoms not or also a hydrogen atom, in case R3 does not represent any hydrogen atom or R2 represents a branched alcohol radical with 3 to 5 carbon atoms, possibly substituted with 1 to 3 hydroxyl groups; and 1 means the numbers 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that of a compound of general formula II (SEE FIGURE), in which R1, R2, Ha1 and 1 are as initially defined, X represents a protective radical for an amino group, for example an acyl group or has the initially mentioned meanings for R4, and Y represents a protective radical and a hydroxyl group for example an acyl, alkyl aryl or in the case where X represents a protecting group for an amino group, represents a hydrogen atom, one or two radicals and protectors are separated in a solvent by means of hydrolysis at temperatures between 0 ° C and the boiling temperature of the solvent used, for example at temperatures between 0 and 100 ° C and a compound of the general formula I, obtained according to the procedure, is transformed, if desired, after its physiologically compatible salts ible with organic or inorganic acids.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2316325A DE2316325A1 (en) | 1972-10-23 | 1973-04-02 | Halo-hydroxy-substd-benzylamines - as secretolytic and antitussive agents |
DE19732320967 DE2320967C3 (en) | 1973-04-26 | New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them | |
DE2346743A DE2346743C3 (en) | 1972-10-23 | 1973-09-17 | 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
MX3141E true MX3141E (en) | 1980-05-06 |
Family
ID=27185164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX360873U MX3141E (en) | 1973-04-02 | 1973-10-23 | PROCEDURE TO PREPARE BENCIL AMINAS |
Country Status (5)
Country | Link |
---|---|
AT (1) | ATA88775A (en) |
ES (4) | ES423976A1 (en) |
MX (1) | MX3141E (en) |
PL (3) | PL91890B1 (en) |
SU (4) | SU533333A3 (en) |
-
1973
- 1973-10-17 AT AT8877573A patent/ATA88775A/en not_active IP Right Cessation
- 1973-10-22 PL PL17667773A patent/PL91890B1/pl unknown
- 1973-10-22 PL PL17667673A patent/PL91891B1/pl unknown
- 1973-10-22 PL PL17667573A patent/PL92541B1/pl unknown
- 1973-10-23 MX MX360873U patent/MX3141E/en unknown
-
1974
- 1974-03-06 ES ES423976A patent/ES423976A1/en not_active Expired
- 1974-03-06 ES ES423975A patent/ES423975A1/en not_active Expired
- 1974-03-06 ES ES423974A patent/ES423974A1/en not_active Expired
- 1974-03-14 ES ES423973A patent/ES423973A1/en not_active Expired
- 1974-10-10 SU SU2065406A patent/SU533333A3/en active
- 1974-10-10 SU SU2065407A patent/SU512696A3/en active
- 1974-10-10 SU SU2065434A patent/SU532338A3/en active
- 1974-10-10 SU SU2065409A patent/SU515443A3/en active
Also Published As
Publication number | Publication date |
---|---|
PL91891B1 (en) | 1977-03-31 |
SU515443A3 (en) | 1976-05-25 |
ES423974A1 (en) | 1976-06-16 |
ATA88775A (en) | 1975-07-15 |
ES423973A1 (en) | 1976-06-16 |
SU533333A3 (en) | 1976-10-25 |
SU532338A3 (en) | 1976-10-15 |
SU512696A3 (en) | 1976-04-30 |
ES423976A1 (en) | 1976-06-16 |
PL91890B1 (en) | 1977-03-31 |
ES423975A1 (en) | 1976-06-16 |
PL92541B1 (en) | 1977-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR247721A1 (en) | Chemical compounds | |
MX3308E (en) | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TIENO-PIRIDINA | |
SE7601755L (en) | USE OF PERFLUORAL CANCULPHONAMIDES AND / OR AMMONIUM SALTS OF PERFLUORAL CANCULPHONIC ACIDS AND / OR CYCLIMMONIUM SALTS OF PERFLUORAL CANCULPHONIC ACIDS AS FORMSLEPLO MOLE MOLES | |
ES392008A1 (en) | Phenylethanolamine derivatives | |
MX3046E (en) | PROCEDURE FOR THE PREPARATION OF ADDITION SALTS OF PIPERIDIL - INDOL DERIVATIVES | |
MX3141E (en) | PROCEDURE TO PREPARE BENCIL AMINAS | |
ES2032582T3 (en) | PROCEDURE FOR PREPARING DERIVATIVES OF THE OXIME OF 1,2,5,6, -TETRAHIDROPIRIDIN -3-CARBOXIALDEHYDE. | |
GB1033777A (en) | Bis-anilide derivatives | |
MX3330E (en) | PROCEDURE FOR THE PREPARATION OF 9-ALCOHILAMINO-ERITROMICINAS AND ITS SALTS | |
ES300822A1 (en) | Procedure for the obtaining of new derivatives fenilalcanolamºnicos (Machine-translation by Google Translate, not legally binding) | |
ES321531A1 (en) | Procedure for the manufacture of new 7- (picolilaminoalquilteofilinas). (Machine-translation by Google Translate, not legally binding) | |
ES308785A1 (en) | Procedure for the preparation of benzimidazolone derivatives. (Machine-translation by Google Translate, not legally binding) | |
MX3034E (en) | PROCEDURE FOR PREPARING ACID ESTERS OF ALKYL IDEN AMINO OXI ALKYL CARBOXYL | |
MX3103E (en) | PROCEDURE TO PREPARE BENCIL AMINAS | |
ES426427A1 (en) | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity | |
MX9300585A (en) | NEW ACID ANMHYDRIDE AND PROCEDURE FOR ITS PREPARATION. | |
ES378202A1 (en) | 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof | |
ES391993A1 (en) | Basically substituted alkyl theophyllines | |
MX3393E (en) | PROCEDURE FOR THE PREPARATION OF ARYALCOHYLAMINES | |
MX3295E (en) | PROCEDURE FOR PREPARING DERIVATIVES OF 2- AMINO ALKYL -1,4- BENZO DI OXANE | |
ES388561A1 (en) | Phenylethanolamine derivatives | |
MX3037E (en) | PROCEDURE FOR PREPARING DERIVATIVES OF DI OXO LANO | |
ES347222A2 (en) | A procedure for the obtaining of 3,4-dihydroxy-phenyl-alcanolamines. (Machine-translation by Google Translate, not legally binding) | |
SE7708175L (en) | 4-BENZAZONE INTERVENTION | |
GR24210B (en) | METHOD OF MANUFACTURING BENZO (A) KINOLIZINE PRODUCERS. |