MX3141E - PROCEDURE TO PREPARE BENCIL AMINAS - Google Patents
PROCEDURE TO PREPARE BENCIL AMINASInfo
- Publication number
- MX3141E MX3141E MX360873U MX360873U MX3141E MX 3141 E MX3141 E MX 3141E MX 360873 U MX360873 U MX 360873U MX 360873 U MX360873 U MX 360873U MX 3141 E MX3141 E MX 3141E
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- radical
- group
- signifies
- hydrogen atom
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de bencilaminas de la fórmula general I, (VER FIGURA), en la que Ha1 significa un átomo de cloro o de bromo, R1 significa un átomo de hidrógeno, cloro o bromo, R2 significa el radical morfolinocarbonilmetilo, un radical alcohilo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidroxilo, o un grupo de la fórmula (VER FIGURA), en donde R3 significa un átomo de hidrógeno, un grupo hidroxi o un grupo alcohilo con 1 a 4 átomos de carbono, n significa los números 0, 1 ó 2 y los dos radicales A y B significan átomos de hidrógeno o conjuntamente el grupo (VER FIGURA), en donde R5 represente un átomo de hidrógeno o un radical alcohilo inferior con 1 o 2 átomos de carbono y m significa los números 1 ó 2, R4 significa un radical alcohilo de cadena recta o ramificada con 1 a 4 átomos de carbono, un radical alquenilo con 2 a 4 átomos de carbono, un radical cicloalcohilo con 3 ó 4 átomos de carbono o también un átomo de hidrógeno, caso que R3 no represente ningún átomo de hidrógeno o R2 represente un radical alcohilo ramificado con 3 a 5 átomos de carbono eventualmente sustituído con 1 a 3 grupos hidroxilo; y 1 significa los números 1 ó 2, así como de sus sales por adición de ácido fisiológicamente compatibles con ácidos orgánicos o inorgánicos, caracterizado porque de un compuesto de fórmula general II (VER FIGURA), en la que R1 , R2, Ha1 y 1 son como se a definido inicialmente,X representa un radical protector para un grupo amino, por ejemplo un grupo acilo o posee los significados inicialmente citados para R4, e Y representa un radical protector y un grupo hidroxilo por ejemplo un grupo acilo, alquilo arilo o en el caso en que X representa un grupo protector par un grupo amino, representa un átomo de hidrógeno, se separa uno o dos radicales y protectores en un disolvente por medio de hidrólisis a temperaturas de entre 0°C y la temperatura de ebullición del disolvente utilizado, por ejemplo a temperaturas de entre 0 y 100°C y un compuesto de la fórmula general I, obtenido de acuerdo con el procedimiento es trasnformado en caso deseado a continuación de sus sales fisiológicamente compatibles con ácidos orgánicos o inorgánicos.The present invention relates to a process for the preparation of benzylamines of the general formula I, (SEE FIGURE), in which Ha1 signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies the morpholinocarbonylmethyl radical, a branched alcohol radical with 3 to 5 carbon atoms, optionally substituted with 1 to 3 hydroxyl groups, or a group of the formula (SEE FIGURE), where R3 signifies a hydrogen atom, a hydroxy group or a group alcohol with 1 to 4 carbon atoms, n means the numbers 0, 1 or 2 and the two radicals A and B mean hydrogen atoms or together the group (SEE FIGURE), where R5 represents a hydrogen atom or an alcohol radical lower with 1 or 2 carbon atoms and m signifies the numbers 1 or 2, R4 signifies a straight chain or branched alcohol radical with 1 to 4 carbon atoms, an alkenyl radical with 2 to 4 carbon atoms, a cycloalcohyl radical with 3 or 4 carbon atoms not or also a hydrogen atom, in case R3 does not represent any hydrogen atom or R2 represents a branched alcohol radical with 3 to 5 carbon atoms, possibly substituted with 1 to 3 hydroxyl groups; and 1 means the numbers 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that of a compound of general formula II (SEE FIGURE), in which R1, R2, Ha1 and 1 are as initially defined, X represents a protective radical for an amino group, for example an acyl group or has the initially mentioned meanings for R4, and Y represents a protective radical and a hydroxyl group for example an acyl, alkyl aryl or in the case where X represents a protecting group for an amino group, represents a hydrogen atom, one or two radicals and protectors are separated in a solvent by means of hydrolysis at temperatures between 0 ° C and the boiling temperature of the solvent used, for example at temperatures between 0 and 100 ° C and a compound of the general formula I, obtained according to the procedure, is transformed, if desired, after its physiologically compatible salts ible with organic or inorganic acids.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2316325A DE2316325A1 (en) | 1972-10-23 | 1973-04-02 | Halo-hydroxy-substd-benzylamines - as secretolytic and antitussive agents |
| DE19732320967 DE2320967C3 (en) | 1973-04-26 | New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them | |
| DE2346743A DE2346743C3 (en) | 1972-10-23 | 1973-09-17 | 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3141E true MX3141E (en) | 1980-05-06 |
Family
ID=27185164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX360873U MX3141E (en) | 1973-04-02 | 1973-10-23 | PROCEDURE TO PREPARE BENCIL AMINAS |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | ATA88775A (en) |
| ES (4) | ES423976A1 (en) |
| MX (1) | MX3141E (en) |
| PL (3) | PL92541B1 (en) |
| SU (4) | SU533333A3 (en) |
-
1973
- 1973-10-17 AT AT8877573A patent/ATA88775A/en not_active IP Right Cessation
- 1973-10-22 PL PL17667573A patent/PL92541B1/pl unknown
- 1973-10-22 PL PL17667673A patent/PL91891B1/pl unknown
- 1973-10-22 PL PL17667773A patent/PL91890B1/pl unknown
- 1973-10-23 MX MX360873U patent/MX3141E/en unknown
-
1974
- 1974-03-06 ES ES423976A patent/ES423976A1/en not_active Expired
- 1974-03-06 ES ES423975A patent/ES423975A1/en not_active Expired
- 1974-03-06 ES ES423974A patent/ES423974A1/en not_active Expired
- 1974-03-14 ES ES423973A patent/ES423973A1/en not_active Expired
- 1974-10-10 SU SU2065406A patent/SU533333A3/en active
- 1974-10-10 SU SU2065409A patent/SU515443A3/en active
- 1974-10-10 SU SU2065407A patent/SU512696A3/en active
- 1974-10-10 SU SU2065434A patent/SU532338A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ATA88775A (en) | 1975-07-15 |
| PL91890B1 (en) | 1977-03-31 |
| SU532338A3 (en) | 1976-10-15 |
| SU515443A3 (en) | 1976-05-25 |
| ES423974A1 (en) | 1976-06-16 |
| PL92541B1 (en) | 1977-04-30 |
| PL91891B1 (en) | 1977-03-31 |
| SU533333A3 (en) | 1976-10-25 |
| ES423975A1 (en) | 1976-06-16 |
| ES423973A1 (en) | 1976-06-16 |
| ES423976A1 (en) | 1976-06-16 |
| SU512696A3 (en) | 1976-04-30 |
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