ES426427A1 - Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity - Google Patents

Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity

Info

Publication number
ES426427A1
ES426427A1 ES426427A ES426427A ES426427A1 ES 426427 A1 ES426427 A1 ES 426427A1 ES 426427 A ES426427 A ES 426427A ES 426427 A ES426427 A ES 426427A ES 426427 A1 ES426427 A1 ES 426427A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
nitro
group
nitrocarbostyrils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES426427A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES426427A1 publication Critical patent/ES426427A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of new nitrocarboestyril derivatives of formula (I) or a pharmaceutically acceptable salt thereof: **(See formula)** where R1, R2, R3 and R4 represent hydrogen or an alkyl, alkoxy, aryloxy, aralkoxy, aryl, aralkyl, heterocyclic, hydroxy, nitro or halogen group or any two of the R1, R2, R3 and R4 groups together with the atoms of carbon to which they are attached complete a carbocyclic ring, substituted or unsubstituted, and R5 represents hydrogen or an alkyl, aryl or aralkyl group, provided that: a) R1, R2, R3, R4 and R5 are not all hydrogen; b) R2 is not a nitro group when R1, R3, R4 and R5 are all hydrogen and e) R2 and R4 are not both a nitro group when R1, R3 and R5 are all hydrogen, whose process comprises the nitration of a compound of formula (II) **(See formula)** where R1, R2, R3, R4 and R5 are those defined by referring to formula (I) and, if desired, salification of the resulting nitro compound. (Machine-translation by Google Translate, not legally binding)
ES426427A 1973-05-19 1974-05-17 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity Expired ES426427A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2400073A GB1453863A (en) 1973-05-19 1973-05-19 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity
GB2431773 1973-05-22

Publications (1)

Publication Number Publication Date
ES426427A1 true ES426427A1 (en) 1976-09-16

Family

ID=26256830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES426427A Expired ES426427A1 (en) 1973-05-19 1974-05-17 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity

Country Status (21)

Country Link
JP (1) JPS5030884A (en)
AR (1) AR201506A1 (en)
AT (1) AT334373B (en)
CA (1) CA1030539A (en)
CH (1) CH601243A5 (en)
DD (1) DD112126A5 (en)
DE (1) DE2424076A1 (en)
DK (1) DK137043B (en)
ES (1) ES426427A1 (en)
FI (1) FI153174A (en)
FR (1) FR2229414B1 (en)
GB (1) GB1453863A (en)
HU (1) HU168001B (en)
IE (1) IE39269B1 (en)
IL (1) IL44849A (en)
IN (1) IN139603B (en)
NL (1) NL7406711A (en)
PH (1) PH10621A (en)
SE (1) SE7406631L (en)
SU (1) SU578869A3 (en)
ZM (1) ZM7974A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065457A (en) * 1973-05-19 1977-12-27 Beecham Group Limited 4-Hydroxy-3-nitro-carbostyril compounds
DE2631317A1 (en) * 1975-07-23 1977-02-17 Sandoz Ag ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING
US4192876A (en) * 1975-07-23 1980-03-11 Sandoz, Inc. 4-Hydroxy-3-nitro-quinoline-2(1H)-ones
JPS5919095B2 (en) * 1977-06-22 1984-05-02 大塚製薬株式会社 Quinoline derivatives and their production method
JPH0681744B2 (en) * 1986-10-06 1994-10-19 三菱化成株式会社 Method for producing 2,4-dioxyquinoline derivative
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists

Also Published As

Publication number Publication date
IE39269L (en) 1974-11-19
FR2229414B1 (en) 1977-11-10
AR201506A1 (en) 1975-03-21
HU168001B (en) 1976-02-28
GB1453863A (en) 1976-10-27
DK137043B (en) 1978-01-09
DD112126A5 (en) 1975-03-20
SU578869A3 (en) 1977-10-30
AT334373B (en) 1976-01-10
AU6915874A (en) 1975-11-20
CH601243A5 (en) 1978-06-30
FI153174A (en) 1974-11-20
DE2424076A1 (en) 1974-12-05
NL7406711A (en) 1974-11-21
JPS5030884A (en) 1975-03-27
IL44849A (en) 1978-04-30
IE39269B1 (en) 1978-08-30
ATA409674A (en) 1976-05-15
ZM7974A1 (en) 1974-12-20
SE7406631L (en) 1974-11-20
PH10621A (en) 1977-07-19
CA1030539A (en) 1978-05-02
FR2229414A1 (en) 1974-12-13
IL44849A0 (en) 1974-07-31
DK137043C (en) 1978-06-05
IN139603B (en) 1976-07-10

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