ES386554A1 - Procedure for preparing propanolamine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing propanolamine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES386554A1
ES386554A1 ES386554A ES386554A ES386554A1 ES 386554 A1 ES386554 A1 ES 386554A1 ES 386554 A ES386554 A ES 386554A ES 386554 A ES386554 A ES 386554A ES 386554 A1 ES386554 A1 ES 386554A1
Authority
ES
Spain
Prior art keywords
group
formula
compound
compounds
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES386554A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2436070A external-priority patent/GB1279877A/en
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of ES386554A1 publication Critical patent/ES386554A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing propanolamine derivatives, of general formula: **(See formula)** wherein R1 is a carboxyamido, lower alkoxycarbonylamino or carbamoyl group, which may be separated from the phenyl ring by a methylene or ethylene group; R2 and R3 are each a hydrogen atom or a lower alkyl group; R4 is a carboxyamido, sulfonamido, lower alkoxycarbonylamino, carbamoyl, or sulfamoyl group, which may be separated from the phenyl ring by a methylene or ethylene group; R5 is a hydrogen atom, a lower alkyl or alkanoyl group, or a benzyl group; X is an oxygen or sulfur atom; Y is an oxygen or sulfur atom; or a sulfinyl, sulfonyl or imino group, or a direct bond; n is 1, 2 or 3, when Y does not represent a direct bond and has a value of 0 to 4 when Y is a direct bond; and each of the phenyl groups attached to X and Y may be further substituted with 1 or more halogen atoms or lower alkyl, alkenyl, alkoxy, or alkenoxy groups; the aldehyde condensation products of said compounds of formula (I) in which R5 is a hydrogen atom, the esters of the compounds of formula (I) in which the 2-hydroxy group is esterified with a lower alkanolic acid and the pharmaceutically acceptable acid addition salts of the compounds of formula (i) and of said esters and aldehyde condensation products, characterized in that it comprises reacting a compound of formula: **(See formula)** with a compound of the formula: **(See formula)** where R18 is the same as R1 or is a nitro group and (a) Z1 is a halogen atom or any suitable "leaving" group, Z2 is a hydroxyl group and Z3 is a -NHR5 group; (B) Z1 is a group -NHR5, Z2 is a hydroxyl group and Z3 is a halogen atom or any suitable "leaving" group; or (C) Z1 and Z2 together represent an epoxy group and Z3 is a -NHR5 group; any of the phenyl groups of the compounds of formulas III and IV may further be optionally substituted as described in connection with formula I; When R18 is a nitro group, it is reduced to an amino group and the latter is acylated; and, if desired, the product is reacted with an aldehyde of formula R15CHO to form an aldehyde condensation product of a compound of formula I in which R''5 is a hydrogen atom, or the product is acylated to form an ester of the compound or a compound wherein R5 is an alkanoyl group, or the product is reacted with an acid to form the non-toxic acid addition salts. (Machine-translation by Google Translate, not legally binding)
ES386554A 1969-12-17 1970-12-17 Procedure for preparing propanolamine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES386554A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB6141469 1969-12-17
GB2436070A GB1279877A (en) 1969-12-17 1969-12-17 Alkanolamine derivatives

Publications (1)

Publication Number Publication Date
ES386554A1 true ES386554A1 (en) 1974-02-16

Family

ID=26257075

Family Applications (1)

Application Number Title Priority Date Filing Date
ES386554A Expired ES386554A1 (en) 1969-12-17 1970-12-17 Procedure for preparing propanolamine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
JP (1) JPS5231858B1 (en)
BE (1) BE760423A (en)
CH (1) CH544064A (en)
DE (1) DE2062055C3 (en)
ES (1) ES386554A1 (en)
FR (1) FR2081371A1 (en)
SE (1) SE382324B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1540463A (en) * 1976-10-07 1979-02-14 Ici Ltd Alkanolamine derivatives
BE883069A (en) * 1979-05-04 1980-08-18 Continental Pharma PHENYLETHYLAMINE DERIVATIVES, THEIR PREPARATION AND USE AS WELL AS A COMPOSITION CONTAINING THESE DERIVATIVES.
DE3423429A1 (en) * 1984-06-26 1986-01-02 Beiersdorf Ag, 2000 Hamburg SUBSTITUTED PHENOXYALKYLAMINOPROPANOLE, METHOD FOR THE PRODUCTION AND USE THEREOF, AND PREPARATIONS CONTAINING THESE COMPOUNDS
US6451814B1 (en) * 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1458635A (en) * 1964-09-30 1966-03-04 Ici Ltd Manufacturing process for new alkanolamines and their derivatives
GB1269775A (en) * 1968-07-18 1972-04-06 Ici Ltd Alkanolamine derivatives
GB1263987A (en) * 1969-05-30 1972-02-16 Allen & Hanburys Ltd Phenethylamine derivatives

Also Published As

Publication number Publication date
JPS5231858B1 (en) 1977-08-17
SE382324B (en) 1976-01-26
BE760423A (en) 1971-06-16
DE2062055C3 (en) 1979-01-18
FR2081371B1 (en) 1974-09-20
FR2081371A1 (en) 1971-12-03
CH544064A (en) 1973-11-15
DE2062055A1 (en) 1971-06-24
DE2062055B2 (en) 1978-05-24

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