FR2081371A1 - Beta-adrenergic blocking propanolamine - derivs - Google Patents

Beta-adrenergic blocking propanolamine - derivs

Info

Publication number
FR2081371A1
FR2081371A1 FR7045437A FR7045437A FR2081371A1 FR 2081371 A1 FR2081371 A1 FR 2081371A1 FR 7045437 A FR7045437 A FR 7045437A FR 7045437 A FR7045437 A FR 7045437A FR 2081371 A1 FR2081371 A1 FR 2081371A1
Authority
FR
France
Prior art keywords
beta
adrenergic blocking
lower alkyl
derivs
propanolamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7045437A
Other languages
French (fr)
Other versions
FR2081371B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2436070A external-priority patent/GB1279877A/en
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of FR2081371A1 publication Critical patent/FR2081371A1/en
Application granted granted Critical
Publication of FR2081371B1 publication Critical patent/FR2081371B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Beta-adrenergic blocking propanolamine derivs. Title cpds. of formula (I) (where R' is carboxyamido (pref. acetamido), lower alkoxycarbonylamino or carbamoyl which can be separated from the phenyl ring by a methylene or ethylene groups; R2 and R3 are H or lower alkyl; R4 is carboxyamido, sulphonamido, lower alkoxycarbonyl: amino, carbamoyl or sulphamoyl which can be separated from the phenyl ring by a methylene or ethylene group; R5 is H, lower alkyl, lower alkanoyl or benzyl, X is O or S; Y is O, S, SO, SO2, NH or a direct bond; n is 1,2 or when Y is a direct bond, also O or 4; and rings A and B may be further substd. by one or more halogen atoms or lower alkyl, alkenyl, alkoxy or alkenoxy groups) and their pharmaceutically tolerable acid addition salts, as well as aldehyde condensation products of (I; R5 = H) and esters in which the 2-hydroxy group is esterified with a lower alkane carboxylic acid. Their beta-adrenergic blocking effect is stronger on cardiac than on peripheral receptors and they are useful for heating e.g. angina pectoris and cardiac arrhythmias.
FR7045437A 1969-12-17 1970-12-16 Beta-adrenergic blocking propanolamine - derivs Granted FR2081371A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB6141469 1969-12-17
GB2436070A GB1279877A (en) 1969-12-17 1969-12-17 Alkanolamine derivatives

Publications (2)

Publication Number Publication Date
FR2081371A1 true FR2081371A1 (en) 1971-12-03
FR2081371B1 FR2081371B1 (en) 1974-09-20

Family

ID=26257075

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7045437A Granted FR2081371A1 (en) 1969-12-17 1970-12-16 Beta-adrenergic blocking propanolamine - derivs

Country Status (7)

Country Link
JP (1) JPS5231858B1 (en)
BE (1) BE760423A (en)
CH (1) CH544064A (en)
DE (1) DE2062055C3 (en)
ES (1) ES386554A1 (en)
FR (1) FR2081371A1 (en)
SE (1) SE382324B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1540463A (en) * 1976-10-07 1979-02-14 Ici Ltd Alkanolamine derivatives
BE883069A (en) * 1979-05-04 1980-08-18 Continental Pharma PHENYLETHYLAMINE DERIVATIVES, THEIR PREPARATION AND USE AS WELL AS A COMPOSITION CONTAINING THESE DERIVATIVES.
DE3423429A1 (en) * 1984-06-26 1986-01-02 Beiersdorf Ag, 2000 Hamburg SUBSTITUTED PHENOXYALKYLAMINOPROPANOLE, METHOD FOR THE PRODUCTION AND USE THEREOF, AND PREPARATIONS CONTAINING THESE COMPOUNDS
US6451814B1 (en) * 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1458635A (en) * 1964-09-30 1966-03-04 Ici Ltd Manufacturing process for new alkanolamines and their derivatives
FR2013209A1 (en) * 1968-07-18 1970-03-27 Ici Ltd
NL7007861A (en) * 1969-05-30 1970-12-02

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1458635A (en) * 1964-09-30 1966-03-04 Ici Ltd Manufacturing process for new alkanolamines and their derivatives
FR2013209A1 (en) * 1968-07-18 1970-03-27 Ici Ltd
NL7007861A (en) * 1969-05-30 1970-12-02

Also Published As

Publication number Publication date
ES386554A1 (en) 1974-02-16
JPS5231858B1 (en) 1977-08-17
SE382324B (en) 1976-01-26
BE760423A (en) 1971-06-16
DE2062055C3 (en) 1979-01-18
FR2081371B1 (en) 1974-09-20
CH544064A (en) 1973-11-15
DE2062055A1 (en) 1971-06-24
DE2062055B2 (en) 1978-05-24

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Legal Events

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