ES409189A1 - Procedure for the preparation of new derivatives of 8-beta-pirimidinoaminomethyl-10-alpha-ergoline. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of 8-beta-pirimidinoaminomethyl-10-alpha-ergoline. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES409189A1 ES409189A1 ES409189A ES409189A ES409189A1 ES 409189 A1 ES409189 A1 ES 409189A1 ES 409189 A ES409189 A ES 409189A ES 409189 A ES409189 A ES 409189A ES 409189 A1 ES409189 A1 ES 409189A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- ergoline
- group
- beta
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of new derivatives of 8beta-pyrimidino-aminomethyl-10alfa-ergolina, of the formula **(See formula)** in which R is taken from the group consisting of hydrogen and methyl; R1 and R2 are taken from the group consisting of hydrogen, C1-6 -alkyl, and phenyl; and R3 is taken from the group consisting of hydrogen, halogen, methyl, ethyl, methoxy, ethoxy, phenyl, nitro, amino, acylamino, cyano and carboxamido, characterized by reacting dihydrolysergamine or 1-methyl-dihydrolysergamine with a compound capable of transforming the amine group into a guanidine group and by reacting the respective 6-methyl or 1,6-dimethyl-8beta-guanidinomethyl-10alpha-ergoline thus obtained with a beta-dicarbonyl compound of the formula in which R1, R2 and R3 have the same meaning that has been attributed to them before, at a temperature of 10º to 150ºC and for a period that varies between 1 hour and 6 days, and the respective derivative of 6-methyl- or 1,6-dimethyl-8beta-pyrimidino-aminomethyl-10alpha-ergoline thus obtained was isolated and purified. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3193271 | 1971-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES409189A1 true ES409189A1 (en) | 1976-01-01 |
Family
ID=11234509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES409189A Expired ES409189A1 (en) | 1971-12-02 | 1972-12-01 | Procedure for the preparation of new derivatives of 8-beta-pirimidinoaminomethyl-10-alpha-ergoline. (Machine-translation by Google Translate, not legally binding) |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5634597B2 (en) |
AT (1) | AT321478B (en) |
AU (1) | AU465155B2 (en) |
BE (1) | BE792188A (en) |
CA (1) | CA975773A (en) |
CH (1) | CH590276A5 (en) |
CS (1) | CS173612B2 (en) |
DE (1) | DE2259012C3 (en) |
DK (1) | DK138689B (en) |
ES (1) | ES409189A1 (en) |
FR (1) | FR2162045A1 (en) |
GB (1) | GB1357238A (en) |
HU (1) | HU165530B (en) |
IE (1) | IE37429B1 (en) |
IL (1) | IL40944A (en) |
NL (1) | NL153197B (en) |
NO (1) | NO136643C (en) |
SE (1) | SE385301B (en) |
SU (1) | SU617014A3 (en) |
ZA (1) | ZA728459B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7416120A (en) * | 1973-12-21 | 1975-06-24 | Farmaceutici Italia | PROCESS FOR PREPARING PYRIMIDINOAMINOMETHYLERGOLINE DERIVATIVES. |
-
0
- BE BE792188D patent/BE792188A/en not_active IP Right Cessation
-
1972
- 1972-11-22 NL NL727215817A patent/NL153197B/en not_active IP Right Cessation
- 1972-11-27 SU SU721851316A patent/SU617014A3/en active
- 1972-11-27 GB GB5474372A patent/GB1357238A/en not_active Expired
- 1972-11-28 IE IE1653/72A patent/IE37429B1/en unknown
- 1972-11-28 CA CA157,696A patent/CA975773A/en not_active Expired
- 1972-11-28 AU AU49351/72A patent/AU465155B2/en not_active Expired
- 1972-11-28 IL IL40944A patent/IL40944A/en unknown
- 1972-11-28 NO NO4351/72A patent/NO136643C/en unknown
- 1972-11-28 AT AT1011572A patent/AT321478B/en active
- 1972-11-29 ZA ZA728459A patent/ZA728459B/en unknown
- 1972-11-29 SE SE7215545A patent/SE385301B/en unknown
- 1972-11-29 DK DK595972AA patent/DK138689B/en unknown
- 1972-11-29 FR FR7242381A patent/FR2162045A1/en active Granted
- 1972-11-30 CS CS8190A patent/CS173612B2/cs unknown
- 1972-11-30 JP JP11945772A patent/JPS5634597B2/ja not_active Expired
- 1972-12-01 HU HUFA933A patent/HU165530B/hu unknown
- 1972-12-01 CH CH1756672A patent/CH590276A5/xx not_active IP Right Cessation
- 1972-12-01 ES ES409189A patent/ES409189A1/en not_active Expired
- 1972-12-01 DE DE2259012A patent/DE2259012C3/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2162045A1 (en) | 1973-07-13 |
DE2259012C3 (en) | 1978-09-21 |
IL40944A (en) | 1976-04-30 |
ZA728459B (en) | 1973-09-26 |
JPS4862800A (en) | 1973-09-01 |
AU4935172A (en) | 1974-05-30 |
NO136643B (en) | 1977-07-04 |
SU617014A3 (en) | 1978-07-25 |
IL40944A0 (en) | 1973-01-30 |
JPS5634597B2 (en) | 1981-08-11 |
AT321478B (en) | 1975-04-10 |
DK138689B (en) | 1978-10-16 |
GB1357238A (en) | 1974-06-19 |
CA975773A (en) | 1975-10-07 |
IE37429B1 (en) | 1977-07-20 |
HU165530B (en) | 1974-09-28 |
CS173612B2 (en) | 1977-02-28 |
DE2259012A1 (en) | 1973-06-07 |
FR2162045B1 (en) | 1976-06-11 |
IE37429L (en) | 1973-06-02 |
DE2259012B2 (en) | 1978-02-09 |
SE385301B (en) | 1976-06-21 |
DK138689C (en) | 1979-03-19 |
AU465155B2 (en) | 1975-09-18 |
NL7215817A (en) | 1973-06-05 |
BE792188A (en) | 1973-06-01 |
NL153197B (en) | 1977-05-16 |
CH590276A5 (en) | 1977-07-29 |
NO136643C (en) | 1977-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19880204 |