IE39269L - Nitrocarbostyrils; pharmaceutical compositions. - Google Patents

Nitrocarbostyrils; pharmaceutical compositions.

Info

Publication number
IE39269L
IE39269L IE741039A IE103974A IE39269L IE 39269 L IE39269 L IE 39269L IE 741039 A IE741039 A IE 741039A IE 103974 A IE103974 A IE 103974A IE 39269 L IE39269 L IE 39269L
Authority
IE
Ireland
Prior art keywords
alkyl
pharmaceutical compositions
benzyl
phenyl
hydrogen
Prior art date
Application number
IE741039A
Other versions
IE39269B1 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE39269L publication Critical patent/IE39269L/en
Publication of IE39269B1 publication Critical patent/IE39269B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes

Abstract

1453863 Antihistamine preparations BEECHAM GROUP Ltd 15 May 1974 [19 May 1973 22 May 1973] 24000/73 and 24317/73 Heading A5B [Also in Division C2] The invention provides pharmaceutical compositions comprising compounds of the formula I and pharmaceutically acceptable salts thereof wherein R 1 , R 2 R 3 and R 4 are hydrogen, halogen, hydroxy, nitro, alkyl, alkoxy, phenyl, benzyl, pyridyl, phenoxy, benzyloxy or any adjacent two of R 1 , R 2 , R 3 and R 4 taken together are a tetramethylene or 1, 3-butadienylene group and R 5 is hydrogen, alkyl, phenyl or benzyl wherein alkyl and alkoxy groups have 1 to 6 carbon atoms, together with one or more pharmaceutically acceptable carriers. The compositions show anti-allergic or immunological activity when administered orally, parenterally or by insufflation. The composition may contain a bronchodilator such as isoprenaline. [GB1453863A]
IE1039/74A 1973-05-19 1974-05-15 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity IE39269B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2400073A GB1453863A (en) 1973-05-19 1973-05-19 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity
GB2431773 1973-05-22

Publications (2)

Publication Number Publication Date
IE39269L true IE39269L (en) 1974-11-19
IE39269B1 IE39269B1 (en) 1978-08-30

Family

ID=26256830

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1039/74A IE39269B1 (en) 1973-05-19 1974-05-15 Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity

Country Status (21)

Country Link
JP (1) JPS5030884A (en)
AR (1) AR201506A1 (en)
AT (1) AT334373B (en)
CA (1) CA1030539A (en)
CH (1) CH601243A5 (en)
DD (1) DD112126A5 (en)
DE (1) DE2424076A1 (en)
DK (1) DK137043B (en)
ES (1) ES426427A1 (en)
FI (1) FI153174A (en)
FR (1) FR2229414B1 (en)
GB (1) GB1453863A (en)
HU (1) HU168001B (en)
IE (1) IE39269B1 (en)
IL (1) IL44849A (en)
IN (1) IN139603B (en)
NL (1) NL7406711A (en)
PH (1) PH10621A (en)
SE (1) SE7406631L (en)
SU (1) SU578869A3 (en)
ZM (1) ZM7974A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065457A (en) * 1973-05-19 1977-12-27 Beecham Group Limited 4-Hydroxy-3-nitro-carbostyril compounds
DE2631317A1 (en) * 1975-07-23 1977-02-17 Sandoz Ag ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING
US4192876A (en) * 1975-07-23 1980-03-11 Sandoz, Inc. 4-Hydroxy-3-nitro-quinoline-2(1H)-ones
JPS5919095B2 (en) * 1977-06-22 1984-05-02 大塚製薬株式会社 Quinoline derivatives and their production method
JPH0681744B2 (en) * 1986-10-06 1994-10-19 三菱化成株式会社 Method for producing 2,4-dioxyquinoline derivative
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists

Also Published As

Publication number Publication date
IN139603B (en) 1976-07-10
ES426427A1 (en) 1976-09-16
IL44849A (en) 1978-04-30
AR201506A1 (en) 1975-03-21
AU6915874A (en) 1975-11-20
CH601243A5 (en) 1978-06-30
DD112126A5 (en) 1975-03-20
SE7406631L (en) 1974-11-20
GB1453863A (en) 1976-10-27
IE39269B1 (en) 1978-08-30
AT334373B (en) 1976-01-10
DE2424076A1 (en) 1974-12-05
FI153174A (en) 1974-11-20
DK137043B (en) 1978-01-09
FR2229414A1 (en) 1974-12-13
FR2229414B1 (en) 1977-11-10
PH10621A (en) 1977-07-19
ATA409674A (en) 1976-05-15
ZM7974A1 (en) 1974-12-20
SU578869A3 (en) 1977-10-30
NL7406711A (en) 1974-11-21
HU168001B (en) 1976-02-28
DK137043C (en) 1978-06-05
JPS5030884A (en) 1975-03-27
IL44849A0 (en) 1974-07-31
CA1030539A (en) 1978-05-02

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