IE39269B1 - Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity - Google Patents
Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivityInfo
- Publication number
- IE39269B1 IE39269B1 IE1039/74A IE103974A IE39269B1 IE 39269 B1 IE39269 B1 IE 39269B1 IE 1039/74 A IE1039/74 A IE 1039/74A IE 103974 A IE103974 A IE 103974A IE 39269 B1 IE39269 B1 IE 39269B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- allergic
- pharmaceutical compositions
- nitrocarbostyrils
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1453863 Antihistamine preparations BEECHAM GROUP Ltd 15 May 1974 [19 May 1973 22 May 1973] 24000/73 and 24317/73 Heading A5B [Also in Division C2] The invention provides pharmaceutical compositions comprising compounds of the formula I and pharmaceutically acceptable salts thereof wherein R 1 , R 2 R 3 and R 4 are hydrogen, halogen, hydroxy, nitro, alkyl, alkoxy, phenyl, benzyl, pyridyl, phenoxy, benzyloxy or any adjacent two of R 1 , R 2 , R 3 and R 4 taken together are a tetramethylene or 1, 3-butadienylene group and R 5 is hydrogen, alkyl, phenyl or benzyl wherein alkyl and alkoxy groups have 1 to 6 carbon atoms, together with one or more pharmaceutically acceptable carriers. The compositions show anti-allergic or immunological activity when administered orally, parenterally or by insufflation. The composition may contain a bronchodilator such as isoprenaline.
[GB1453863A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2400073A GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| GB2431773 | 1973-05-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39269L IE39269L (en) | 1974-11-19 |
| IE39269B1 true IE39269B1 (en) | 1978-08-30 |
Family
ID=26256830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1039/74A IE39269B1 (en) | 1973-05-19 | 1974-05-15 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5030884A (en) |
| AR (1) | AR201506A1 (en) |
| AT (1) | AT334373B (en) |
| CA (1) | CA1030539A (en) |
| CH (1) | CH601243A5 (en) |
| DD (1) | DD112126A5 (en) |
| DE (1) | DE2424076A1 (en) |
| DK (1) | DK137043B (en) |
| ES (1) | ES426427A1 (en) |
| FI (1) | FI153174A (en) |
| FR (1) | FR2229414B1 (en) |
| GB (1) | GB1453863A (en) |
| HU (1) | HU168001B (en) |
| IE (1) | IE39269B1 (en) |
| IL (1) | IL44849A (en) |
| IN (1) | IN139603B (en) |
| NL (1) | NL7406711A (en) |
| PH (1) | PH10621A (en) |
| SE (1) | SE7406631L (en) |
| SU (1) | SU578869A3 (en) |
| ZM (1) | ZM7974A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065457A (en) * | 1973-05-19 | 1977-12-27 | Beecham Group Limited | 4-Hydroxy-3-nitro-carbostyril compounds |
| US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
| DE2631317A1 (en) * | 1975-07-23 | 1977-02-17 | Sandoz Ag | ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING |
| JPS5919095B2 (en) * | 1977-06-22 | 1984-05-02 | 大塚製薬株式会社 | Quinoline derivatives and their production method |
| JPH0681744B2 (en) * | 1986-10-06 | 1994-10-19 | 三菱化成株式会社 | Method for producing 2,4-dioxyquinoline derivative |
| US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
-
1973
- 1973-05-19 GB GB2400073A patent/GB1453863A/en not_active Expired
-
1974
- 1974-05-15 IE IE1039/74A patent/IE39269B1/en unknown
- 1974-05-17 CH CH683674A patent/CH601243A5/xx not_active IP Right Cessation
- 1974-05-17 SE SE7406631A patent/SE7406631L/xx unknown
- 1974-05-17 NL NL7406711A patent/NL7406711A/xx not_active Application Discontinuation
- 1974-05-17 IL IL44849A patent/IL44849A/en unknown
- 1974-05-17 DK DK273074AA patent/DK137043B/en unknown
- 1974-05-17 HU HUBE1198A patent/HU168001B/hu unknown
- 1974-05-17 DE DE2424076A patent/DE2424076A1/en active Pending
- 1974-05-17 SU SU7402031653A patent/SU578869A3/en active
- 1974-05-17 FR FR7417170A patent/FR2229414B1/fr not_active Expired
- 1974-05-17 AT AT409674A patent/AT334373B/en not_active IP Right Cessation
- 1974-05-17 CA CA200,335A patent/CA1030539A/en not_active Expired
- 1974-05-17 FI FI1531/74A patent/FI153174A/fi unknown
- 1974-05-17 ES ES426427A patent/ES426427A1/en not_active Expired
- 1974-05-20 JP JP49056448A patent/JPS5030884A/ja active Pending
- 1974-05-20 AR AR253837A patent/AR201506A1/en active
- 1974-05-20 PH PH15854A patent/PH10621A/en unknown
- 1974-05-20 DD DD178631A patent/DD112126A5/xx unknown
- 1974-05-20 ZM ZM79/74A patent/ZM7974A1/en unknown
- 1974-06-18 IN IN1344/CAL/74A patent/IN139603B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU578869A3 (en) | 1977-10-30 |
| ZM7974A1 (en) | 1974-12-20 |
| FR2229414A1 (en) | 1974-12-13 |
| AT334373B (en) | 1976-01-10 |
| JPS5030884A (en) | 1975-03-27 |
| CH601243A5 (en) | 1978-06-30 |
| ES426427A1 (en) | 1976-09-16 |
| DD112126A5 (en) | 1975-03-20 |
| IL44849A0 (en) | 1974-07-31 |
| IN139603B (en) | 1976-07-10 |
| DE2424076A1 (en) | 1974-12-05 |
| NL7406711A (en) | 1974-11-21 |
| GB1453863A (en) | 1976-10-27 |
| AR201506A1 (en) | 1975-03-21 |
| FR2229414B1 (en) | 1977-11-10 |
| DK137043B (en) | 1978-01-09 |
| IE39269L (en) | 1974-11-19 |
| DK137043C (en) | 1978-06-05 |
| SE7406631L (en) | 1974-11-20 |
| ATA409674A (en) | 1976-05-15 |
| AU6915874A (en) | 1975-11-20 |
| CA1030539A (en) | 1978-05-02 |
| IL44849A (en) | 1978-04-30 |
| HU168001B (en) | 1976-02-28 |
| PH10621A (en) | 1977-07-19 |
| FI153174A (en) | 1974-11-20 |
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