ES427560A1 - Procedure for the preparation of new derivatives of cyclobutane. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of cyclobutane. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES427560A1 ES427560A1 ES74427560A ES427560A ES427560A1 ES 427560 A1 ES427560 A1 ES 427560A1 ES 74427560 A ES74427560 A ES 74427560A ES 427560 A ES427560 A ES 427560A ES 427560 A1 ES427560 A1 ES 427560A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- radical
- general formula
- radicals
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new cyclobutane derivatives of the general formula **(See formula)** where R1 to R3, which may be the same or different, signify hydrogen atoms, halogen atoms, hydroxy, trifluoromethyl, benzyloxy, acyloxy groups, alcohol radicals with 1 to 6 carbon atoms, alkoxy radicals with 1 to 3 carbon atoms. carbon or two of the radicals R1 to R3 together signify a methylenedioxy group; R4 signifies a hydrogen atom or an alcohol radical with 1 or 2 carbon atoms; R5 signifies a hydrogen atom or an alcohol radical with 1 to 3 carbon atoms; and R6 means a phenyl radical that can be monosubstituted or disubstituted with a halogen atom, trifluoromethyl groups, hydroxy, nitro, amino, benzyloxy, acyloxy, alcohol radicals with 1 to 3 carbon atoms, alkoxy radicals with 1 to 3 carbon atoms or alcoholylthio radicals with 1 to 3 carbon atoms, or a pyridyl radical optionally substituted with a halogen atom, a hydroxy, nitro, amino, benzyloxy, acyloxy, carboxy group, a carbalkoxy radical with 1 to 3 carbon atoms, a radical alcohol with 1 to 3 carbon atoms or an alkoxy radical with 1 to 3 carbon atoms, as well as its salts with physiologically compatible organic or inorganic acids or bases, characterized in that a compound of the general formula II is reacted **(See formula)** wherein R1 through R4 are as initially defined and X represents a halogen atom or the para-toluenesulfonyloxy radical, with an amine of the general formula III, R6-NH2 wherein R6 is as initially defined and, if a compound of the general formula I, which is substituted with one or more halogen atoms, is obtained according to the method, it is then dehalogenated if desired, and/or a cis/trans mixture, obtained, of a compound of the general formula I is, if desired, subsequently divided into the corresponding cis and trans compounds, and/or a compound obtained of the general formula I in which the radicals R1 to R3 signify acyloxy groups and/or the radical R6 contains an acyloxy and/or carbalkoxy group, is subsequently transformed into the corresponding compound with free hydroxy or carboxyl groups, and/or a compound obtained of the general formula I, which contains free hydroxy groups, is acylated or alcoholized if desired below, and/or a compound of the general formula I obtained is transformed, if desired, with organic or inorganic acids or bases, into their physical salts iologically compatible. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19732349639 DE2349639A1 (en) | 1973-10-03 | 1973-10-03 | Cyclobutanol pharmaceuticals - 1-phenyl-2,2-dimethyl-3- piperazinyl-cyclobutanol derivs, sedatives, muscle relaxants, CNS depressants and anxiolytics |
Publications (1)
Publication Number | Publication Date |
---|---|
ES427560A1 true ES427560A1 (en) | 1976-07-16 |
Family
ID=5894401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES74427560A Expired ES427560A1 (en) | 1973-10-03 | 1974-06-22 | Procedure for the preparation of new derivatives of cyclobutane. (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
Country | Link |
---|---|
CH (1) | CH593269A5 (en) |
DE (1) | DE2349639A1 (en) |
ES (1) | ES427560A1 (en) |
PL (1) | PL92387B1 (en) |
SU (1) | SU528033A3 (en) |
-
1973
- 1973-10-03 DE DE19732349639 patent/DE2349639A1/en not_active Withdrawn
- 1973-11-07 CH CH1471076A patent/CH593269A5/xx not_active IP Right Cessation
- 1973-11-10 PL PL18264073A patent/PL92387B1/pl unknown
-
1974
- 1974-06-22 ES ES74427560A patent/ES427560A1/en not_active Expired
- 1974-10-23 SU SU2069585A patent/SU528033A3/en active
Also Published As
Publication number | Publication date |
---|---|
DE2349639A1 (en) | 1975-04-24 |
PL92387B1 (en) | 1977-04-30 |
SU528033A3 (en) | 1976-09-05 |
CH593269A5 (en) | 1977-11-30 |
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