ES437195A1 - Procedure for the preparation of new derivatives of quinolein. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of quinolein. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES437195A1 ES437195A1 ES437195A ES437195A ES437195A1 ES 437195 A1 ES437195 A1 ES 437195A1 ES 437195 A ES437195 A ES 437195A ES 437195 A ES437195 A ES 437195A ES 437195 A1 ES437195 A1 ES 437195A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- radical
- carbon atoms
- formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for the preparation of new quinoline derivatives of the general formula I, **(See formula)** wherein A represents a group of the formula (see formula) where R1 signifies a hydrogen atom, a branched or straight chain alcohol radical of 1 to 6 carbon atoms, which may be substituted with a hydroxy or methoxy group, a benzyl radical optionally substituted with a methyl group, or an alkenyl radical of 3 to 6 carbon atoms; R2 signifies a hydrogen atom, a hydroxyl group, an alcohol or alkoxy radical each with 1 to 3 carbon atoms, an amino, dimethylamino, morpholino group or a halogen atom; means a hydrogen or halogen atom, a hydroxy group, a straight or branched chain alcohol radical of 1 to 6 carbon atoms, a cycloalkoxy radical of 3 to 6 carbon atoms, an alkoxy group of 1 to 3 carbon atoms, which may be substituted with a phenyl radical, a hydroxymethyl, phenyl, phenoxy, amino, pyrrolidine or morpholino group; R4, R5 and R6, which may be the same or different, signify hydrogen or halogen atoms, methyl, hydroxy, methoxy, amino, nitro, trifluoromethyl groups, or two of the radicals R4, R5 or R6 together signify the methylenedioxy group; X1 and X2 signify hydrogen atoms or together an additional bond, as well as of the 6-N-oxides of these and their acid edition salts physiologically compatible with organic or inorganic acids, characterized in that a quinoline derivative of the general formula II **(See formula)** wherein R2, R4, R5, R6, X1 and X2 are as initially defined; R3'means a carboxy group or the meanings initially mentioned for R3; and A represents a group of the formula (see formula), where R1 has the meanings initially mentioned for said radical in the event that R3 represents a carboxy group, or an alkanoyl radical with 1 to 6 carbon atoms, an optionally benzoyl radical substituted with a methyl group or an alkenoyl radical with 3 to 6 carbon atoms, it is reduced, in a solvent, with a complex metal hydride, and if desired a compound of the general formula I obtained is transformed with an inorganic or organic acid in a physiologically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2442097A DE2442097A1 (en) | 1974-09-03 | 1974-09-03 | Di- or tetra hydro-azepino (4,5-b) or (4,3-b)-quinolines - anorexigenics which have only weak cardiovascular and motility effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES437195A1 true ES437195A1 (en) | 1977-01-16 |
Family
ID=5924736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES437195A Expired ES437195A1 (en) | 1974-09-03 | 1975-04-29 | Procedure for the preparation of new derivatives of quinolein. (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU7535774A (en) |
| DE (1) | DE2442097A1 (en) |
| ES (1) | ES437195A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897595B2 (en) | 2006-05-26 | 2011-03-01 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
-
1974
- 1974-09-03 DE DE2442097A patent/DE2442097A1/en not_active Withdrawn
- 1974-11-14 AU AU75357/74A patent/AU7535774A/en not_active Expired
-
1975
- 1975-04-29 ES ES437195A patent/ES437195A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2442097A1 (en) | 1976-03-18 |
| AU7535774A (en) | 1976-05-20 |
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