ES437193A1 - Procedure for the preparation of new derivatives of quinolein. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new quinoline derivatives of the general formula I, **(See formula)** wherein A represents a group of the formula -CH2-N where R1 signifies a carbalkoxy radical of 2 to 7 carbon atoms, a carbocycloalkoxy radical of 4 to 7 carbon atoms, a phenoxycarbonyl or banzyloxycarbonyl group; R2 signifies a hydrogen atom, a hydroxyl group, an alcohol or alkoxy radical each with 1 to 3 carbon atoms, an acyloxy radical with 1 to 3 carbon atoms, an alcohol alkoxycarbonyloxy radical with 2 to 4 carbon atoms, a amino, dimethylamino, morpholino group or a halogen atom; R3 signifies a hydrogen or halogen atom, a hydroxy or carboxy group, a straight or branched chain alcohol radical of 1 to 6 carbon atoms, a cycloalkoxy radical of 3 to 6 carbon atoms, an alkoxy group of 1 to 3 carbon atoms, which may be substituted with a phenyl or carbalkoxy radical of 2 to 4 carbon atoms, a carbalcosi radical of 2 to 4 carbon atoms, a hydroxymethyl, phenyl, phenoxy, amino, pyrrolidine or morpholine group; R4, R5 and R6, which may be the same or different, mean hydrogen or halogen atoms, methyl, hydroxy, methoxy, cyano, amino, nitro, trifluoromethyl, carboxy, acetyl, carbalkoxy groups of 2 to 4 carbon atoms or two of the radicals R4, R5 or R6 together signify the methylenedioxy group; and they represent hydrogen atoms or together a further bond, as well as the 6-N-oxides of these and their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a quinine derivative of the general formula II **(See formula)** wherein R2 A R6, X1 and X2 are as initially defined and A represents a group of the formula (see formula), R1 representing an alcoholic or aralcohyl group, with a formic acid ester of the general formula III Hal - COOR1 (III) where R1 is as initially defined and Hal represents a chlorine, bromine or iodine atom, and eventually a subsequent hydrolysis is carried out. (Machine-translation by Google Translate, not legally binding)