ES403546A1 - Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application - Google Patents

Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application

Info

Publication number
ES403546A1
ES403546A1 ES403546A ES403546A ES403546A1 ES 403546 A1 ES403546 A1 ES 403546A1 ES 403546 A ES403546 A ES 403546A ES 403546 A ES403546 A ES 403546A ES 403546 A1 ES403546 A1 ES 403546A1
Authority
ES
Spain
Prior art keywords
formula
methyl
hydroxy
ethoxycarbonyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES403546A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES403546A1 publication Critical patent/ES403546A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedure for preparing new derivatives of substituted hydroxy-5-piperazinomethyl-4-indole, of formula: **(See formula)** where R represents an ethoxycarbonylmethyl chain; a dihydroxypropyl chain; or a chain -CH2CON (R', R''), where R' and R'' represent a hydrogen atom or an alcoholic group comprising 1 to 3 carbon atoms, the group -N (R'R) may represent "), likewise, a pyrrolidine or morpholino nucleus; said process characterized by consisting of condensing, in acetic acid and in the presence of trioxymethylene, the ethoxycarbonyl-3-hydroxy-5-methyl-2-indole of formula: **(See formula)** v a monosubstituted piperazine, of the formula: **(See formula)** where R has the same meaning as in formula (I). (Machine-translation by Google Translate, not legally binding)
ES403546A 1971-06-07 1972-06-06 Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application Expired ES403546A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7120476A FR2140260B1 (en) 1971-06-07 1971-06-07

Publications (1)

Publication Number Publication Date
ES403546A1 true ES403546A1 (en) 1975-05-01

Family

ID=9078186

Family Applications (1)

Application Number Title Priority Date Filing Date
ES403546A Expired ES403546A1 (en) 1971-06-07 1972-06-06 Derivatives of 3-ethoxycarbonyl-5-hydroxy-2-methyl-4-piperazino methyl substituted indoles their processes of preparation and their therapeutic application

Country Status (11)

Country Link
JP (1) JPS5132632B1 (en)
BE (1) BE784196A (en)
CA (1) CA954862A (en)
CH (1) CH540918A (en)
DE (1) DE2227487C3 (en)
ES (1) ES403546A1 (en)
FR (1) FR2140260B1 (en)
GB (1) GB1333359A (en)
IT (1) IT1051252B (en)
LU (1) LU65463A1 (en)
NL (1) NL7207639A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421900A1 (en) * 1977-03-17 1979-11-02 Sauba Lab PIPERAZINO-3-INDOLES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Also Published As

Publication number Publication date
DE2227487C3 (en) 1978-03-16
CH540918A (en) 1973-08-31
DE2227487A1 (en) 1972-12-21
DE2227487B2 (en) 1977-06-30
CA954862A (en) 1974-09-17
GB1333359A (en) 1973-10-10
BE784196A (en) 1972-11-30
LU65463A1 (en) 1973-01-22
JPS5132632B1 (en) 1976-09-14
FR2140260B1 (en) 1974-08-30
NL7207639A (en) 1972-12-11
IT1051252B (en) 1981-04-21
FR2140260A1 (en) 1973-01-19

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