ES387554A1 - Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas. - Google Patents

Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas.

Info

Publication number
ES387554A1
ES387554A1 ES387554A ES387554A ES387554A1 ES 387554 A1 ES387554 A1 ES 387554A1 ES 387554 A ES387554 A ES 387554A ES 387554 A ES387554 A ES 387554A ES 387554 A1 ES387554 A1 ES 387554A1
Authority
ES
Spain
Prior art keywords
general formula
radicals
signify
acid
pyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES387554A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19702003714 external-priority patent/DE2003714C/de
Priority claimed from DE19702058086 external-priority patent/DE2058086A1/de
Priority claimed from DE19702058085 external-priority patent/DE2058085A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES387554A1 publication Critical patent/ES387554A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES387554A 1970-01-28 1971-01-23 Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas. Expired ES387554A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19702003714 DE2003714C (de) 1970-01-28 2 Piperazino 4 morpholino thieno eckige Klammer auf 3,2 d eckige Klammer zu pyrimidin und dessen Saureadditions salze
DE19702058086 DE2058086A1 (de) 1970-11-26 1970-11-26 Neue 4-Morpholino-thieno[3,2-d]pyrimidine,deren Salze und Verfahren zur Herstellung
DE19702058085 DE2058085A1 (de) 1970-11-26 1970-11-26 Neues Verfahren zur Herstellung von 4-Morpholino-thieno[3,2-d]pyrimidinen

Publications (1)

Publication Number Publication Date
ES387554A1 true ES387554A1 (es) 1974-01-16

Family

ID=27182372

Family Applications (2)

Application Number Title Priority Date Filing Date
ES387554A Expired ES387554A1 (es) 1970-01-28 1971-01-23 Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas.
ES387553A Expired ES387553A1 (es) 1970-01-28 1971-01-23 Procedimiento para la preparacion de 4-morfolino-tieno (3,-2-d)-pirimidinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES387553A Expired ES387553A1 (es) 1970-01-28 1971-01-23 Procedimiento para la preparacion de 4-morfolino-tieno (3,-2-d)-pirimidinas.

Country Status (9)

Country Link
US (1) US3763156A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2468871A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE762135A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES387554A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2081464B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1309182A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL36079A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7101043A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO129205B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1570494A (en) * 1975-11-28 1980-07-02 Ici Ltd Thienopyrimidine derivatives and their use as pesticides
US5280026A (en) * 1989-05-30 1994-01-18 Smithkline Beecham Intercredit B.V. Thienopyrimidines
GB8912335D0 (en) * 1989-05-30 1989-07-12 Smithkline Beckman Intercredit Compounds
US5098902A (en) * 1991-03-18 1992-03-24 Warner-Lambert Company Method of treating neurodegenerative diseases
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
GB0423653D0 (en) * 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
DE102005019201A1 (de) * 2006-04-19 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
MX2008013584A (es) 2006-04-26 2009-03-23 Genentech Inc Compuestos farmaceuticos.
BRPI0710908A2 (pt) 2006-04-26 2012-06-26 Genentech Inc compostos inibidores de fosfoinositìdeo 3-cinase e composições farmacêuticas contendo-os
US7781433B2 (en) 2006-04-26 2010-08-24 Piramed Limited Pharmaceutical compounds
WO2008070740A1 (en) * 2006-12-07 2008-06-12 F.Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
JP5500990B2 (ja) * 2006-12-07 2014-05-21 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法
JP5736171B2 (ja) 2007-09-24 2015-06-17 ジェネンテック， インコーポレイテッド チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法
ME01330B (me) * 2007-10-19 2013-12-20 Boehringer Ingelheim Int Supstituisani piperidino-dihidrotienopirimidini
CA2702524A1 (en) * 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh Heterocycle-substituted piperazino-dihydrothienopyrimidines
JP5563466B2 (ja) 2007-10-19 2014-07-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ピペラジノ−ジヒドロチエノピリミジン誘導体
CN101909631B (zh) * 2007-10-25 2012-09-12 健泰科生物技术公司 制备噻吩并嘧啶化合物的方法
GB0721095D0 (en) * 2007-10-26 2007-12-05 Piramed Ltd Pharmaceutical compounds
AU2010224125B2 (en) 2009-03-12 2015-05-14 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
EP2451811A1 (en) * 2009-05-27 2012-05-16 F. Hoffmann-La Roche AG Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
US8173650B2 (en) 2009-05-27 2012-05-08 Genentech, Inc. Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
RU2563193C2 (ru) * 2009-10-12 2015-09-20 Ф.Хоффманн-Ля Рош Аг Комбинации ингибитора pi3k и ингибитора мек
KR20130058672A (ko) 2010-04-16 2013-06-04 제넨테크, 인크. ＰＩ3Ｋ/ＡＫＴ 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 ＦＯＸＯ３ａ
WO2012088254A1 (en) 2010-12-22 2012-06-28 Genentech, Inc. Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2959014B1 (en) 2013-02-25 2019-11-13 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
CN113423711B (zh) * 2018-10-01 2024-03-15 建新公司 作为udp糖基转移酶抑制剂的噻吩并[3,2-b]吡啶衍生物及其使用方法
GB202014736D0 (en) * 2020-09-18 2020-11-04 Imperial College Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470356A1 (de) * 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IL36079A0 (en) 1971-03-24
US3763156A (en) 1973-10-02
BE762135A (fr) 1971-07-27
NL7101043A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-07-30
GB1309182A (en) 1973-03-07
FR2081464A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-12-03
AU2468871A (en) 1972-07-27
ES387553A1 (es) 1974-01-16
FR2081464B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-18
NO129205B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-03-11

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