ES376689A1 - Procedimiento para la produccion de 6-fenil-s-triazolo-(4,3-a) (1,4)-benzodiacepinas. - Google Patents

Procedimiento para la produccion de 6-fenil-s-triazolo-(4,3-a) (1,4)-benzodiacepinas.

Info

Publication number
ES376689A1
ES376689A1 ES376689A ES376689A ES376689A1 ES 376689 A1 ES376689 A1 ES 376689A1 ES 376689 A ES376689 A ES 376689A ES 376689 A ES376689 A ES 376689A ES 376689 A1 ES376689 A1 ES 376689A1
Authority
ES
Spain
Prior art keywords
formula
phenyl
carbon atoms
atoms inclusive
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES376689A
Other languages
English (en)
Inventor
Jackson Boling Hester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES376689(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES376689A1 publication Critical patent/ES376689A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
ES376689A 1969-03-17 1970-02-18 Procedimiento para la produccion de 6-fenil-s-triazolo-(4,3-a) (1,4)-benzodiacepinas. Expired ES376689A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80793369A 1969-03-17 1969-03-17
US04/872,394 US3987052A (en) 1969-03-17 1969-10-29 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Publications (1)

Publication Number Publication Date
ES376689A1 true ES376689A1 (es) 1972-05-01

Family

ID=27123060

Family Applications (1)

Application Number Title Priority Date Filing Date
ES376689A Expired ES376689A1 (es) 1969-03-17 1970-02-18 Procedimiento para la produccion de 6-fenil-s-triazolo-(4,3-a) (1,4)-benzodiacepinas.

Country Status (18)

Country Link
US (1) US3987052A (es)
JP (1) JPS4940239B1 (es)
AU (2) AU491139B2 (es)
BE (1) BE747493A (es)
BR (1) BR7017488D0 (es)
CH (1) CH535788A (es)
DE (1) DE2012190C3 (es)
ES (1) ES376689A1 (es)
FR (1) FR2034999A1 (es)
GB (1) GB1291631A (es)
HK (1) HK61677A (es)
IL (1) IL33859A (es)
NL (2) NL172510C (es)
OA (1) OA03446A (es)
PH (1) PH9329A (es)
PL (1) PL80541B1 (es)
SE (1) SE387641B (es)
YU (1) YU35139B (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE779988R (fr) * 1969-03-17 1972-08-29 Upjohn Co Nouvelles 6-phenyl-4h-s-triazolo(4,3-a)(1,4)- benzodiazepines douees d'activite pharmacologique et leur procede de
BE758921A (fr) * 1969-11-15 1971-04-16 Takeda Chemical Industries Ltd Derives de benzodiazepine
BE759099A (fr) * 1969-11-18 1971-04-30 Takeda Chemical Industries Ltd Procede de fabrication de composes heterocycliques
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
DE2156472A1 (de) * 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
CH544764A (de) * 1971-01-21 1974-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3709898A (en) * 1971-02-09 1973-01-09 Upjohn Co Process for the production of triazolobenzodiazepines and intermediates
YU36376B (en) * 1971-03-03 1983-06-30 Upjohn Co Process for producing dihalo-6-phenyltriazolobenzodiazepine-5-n-oxide
DE2164777A1 (de) * 1971-03-03 1972-09-07 Upjohn Co 8-Nitro-6-(o-halogenphenyl)-l-methyl-4H-s-triazolo eckige Klammer auf 4,3-a eckige Klammer zu-eckige Klammer auf 1-4 eckige Klammer zu benzodiazepine und diese enthaltende pharmazeutische Präparate
DE2164778C2 (de) * 1971-03-03 1984-07-05 The Upjohn Co., Kalamazoo, Mich. 6-(o-Chlorphenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepin und dieses enthaltende pharmazeutische Präparat
CH545302A (de) * 1971-04-08 1974-01-13 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3759943A (en) * 1971-04-28 1973-09-18 Upjohn Co Amido and amino triazolo benzodiazepines
GB1331015A (en) * 1971-04-28 1973-09-19 Upjohn Co 1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines
US3709899A (en) 1971-04-28 1973-01-09 Upjohn Co 6-phenyl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines and their production
US4141902A (en) 1971-04-28 1979-02-27 The Upjohn Company 1-Halomethyl-6-phenyl-4H-s-[4,3-a][1,4]benzodiazepines
GB1323277A (en) * 1971-05-10 1973-07-11 Upjohn Co Triazolobenzodiazepines
US3734922A (en) * 1971-05-11 1973-05-22 Upjohn Co Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US4000289A (en) * 1971-07-08 1976-12-28 The Upjohn Company Animal feed and process
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
US3870793A (en) * 1971-08-09 1975-03-11 Upjohn Co Animal feed and process
GB1373300A (en) * 1971-09-08 1974-11-06 Upjohn Co Triazolobenzodiazepines and the manufacture thereof
GB1381158A (en) * 1971-09-13 1975-01-22 Upjohn Co Benzodiazepines and the manufacture thereof
US3767661A (en) * 1971-09-13 1973-10-23 Upjohn Co 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US3714178A (en) * 1971-09-30 1973-01-30 Upjohn Co 6,7-DIHYDRO-7-ALKYL-5H-1,2,4-TRIAZOLO[4,3-d][1,4]BENZODIAZEPINES AND THEIR PRODUCTION
BE790838A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant
FI53821C (fi) * 1971-11-15 1978-08-10 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
FR2128552A2 (en) * 1972-03-02 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as anxiolytic agents, muscle relaxants
CH572056A5 (es) * 1972-11-28 1976-01-30 Ciba Geigy Ag
CH579083A5 (es) * 1972-12-29 1976-08-31 Ciba Geigy Ag
US4978753A (en) * 1973-01-15 1990-12-18 The Upjohn Company 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones
US4082761A (en) * 1973-09-04 1978-04-04 The Upjohn Company Triazolo[4,3-a][1,4]benzodiazepinium quaternary salts
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4455307A (en) * 1982-01-04 1984-06-19 The Upjohn Company Antihypertensive use of triazolobenzodiazepines
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4481208A (en) * 1983-06-06 1984-11-06 The Upjohn Company Treatment of panic disorders with estazolam
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
DE3332830A1 (de) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden
US4689413A (en) * 1983-03-17 1987-08-25 The Upjohn Company Triazolo-benzodiazepine-1-ethanamines as diuretics
US4514407A (en) * 1983-03-17 1985-04-30 The Upjohn Company 1-Ethanamine-triazolo-benzodiazepines as diuretics
US4474699A (en) * 1983-05-25 1984-10-02 The Upjohn Company Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4634703A (en) * 1985-10-25 1987-01-06 Bristol-Myers Company Method for alleviation of panic disorders
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
US4856303A (en) * 1988-07-21 1989-08-15 Whirlpool Corporation Agitator thrust spacer for automatic washer
US5225198A (en) * 1991-08-27 1993-07-06 Cygnus Therapeutic Systems Transdermal administration of short or intermediate half-life benzodiazepines
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
EP0721348B1 (en) * 1993-09-29 1999-09-01 Alza Corporation Monoglyceride/lactate ester permeation enhancer
US6348485B1 (en) 1998-06-09 2002-02-19 Takeda Chemical Industries, Ltd. Method for treating or preventing sleep disorders
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
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US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
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US20070087055A1 (en) * 2005-10-14 2007-04-19 David Jan Directly compressible extended release alprazolam formulation
US20070218135A1 (en) * 2006-03-14 2007-09-20 Glenmark Pharmaceuticals Limited Sustained release matrix pharmaceutical composition
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
US8106189B2 (en) * 2007-10-03 2012-01-31 Centaur Chemicals Pvt Ltd Process for preparation of triazol-benzodiazepine derivatives
EP2087893B1 (en) 2008-02-05 2013-02-13 Laboratorios Bagó S.A. Compositions comprising alprazolam for treating primary insomnia and insomnia associated with anxiety states and processes for preparing them
US20090258865A1 (en) * 2008-03-28 2009-10-15 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
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JP7139323B2 (ja) 2016-11-01 2022-09-20 エフ．ホフマン－ラ ロシュ アーゲー Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
DK3551189T3 (da) 2016-12-09 2024-01-29 Alexza Pharmaceuticals Inc Alprazolam til anvendelse ved behandling af epilepsi
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TW202200585A (zh) 2020-03-31 2022-01-01 瑞士商赫孚孟拉羅股份公司 作為 GABA A γ1 PAM 的新穎苯并二氮呯衍生物
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US2891862A (en) * 1956-11-06 1959-06-23 Eastman Kodak Co Stabilized photographic silver halide emulsions
NL295083A (es) * 1962-07-10
US3523947A (en) * 1966-11-23 1970-08-11 Hoffmann La Roche 1-cyclic amidine-5-aryl-1,4-benzodiazepine and process

Also Published As

Publication number Publication date
NL8100081A (nl) 1981-04-29
NL170857B (nl) 1982-08-02
NL170857C (nl) 1983-01-03
BE747493A (fr) 1970-09-17
DE2012190C3 (de) 1980-11-13
NL7003750A (nl) 1970-09-21
DE2012190B2 (de) 1980-03-06
NL172510B (nl) 1983-04-18
OA03446A (fr) 1971-03-30
FR2034999A1 (fr) 1970-12-18
CH535788A (de) 1973-04-15
AU8549975A (en) 1975-12-18
YU35139B (en) 1980-09-25
IL33859A0 (en) 1970-04-20
SE387641B (sv) 1976-09-13
PL80541B1 (pl) 1975-08-30
AU490626B2 (en) 1975-12-18
PH9329A (en) 1975-09-23
AU491139B2 (en) 1975-12-18
AU8550075A (en) 1975-12-18
FR2034999B1 (es) 1973-07-13
IL33859A (en) 1973-01-30
JPS4940239B1 (es) 1974-10-31
YU34570A (en) 1979-04-30
US3987052A (en) 1976-10-19
NL172510C (nl) 1983-09-16
HK61677A (en) 1977-12-23
BR7017488D0 (pt) 1973-02-13
DE2012190A1 (de) 1970-09-24
GB1291631A (en) 1972-10-04

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