ES306226A1 - Procedimiento de preparaciën de nuevos derivados de la pirimidina - Google Patents

Procedimiento de preparaciën de nuevos derivados de la pirimidina

Info

Publication number
ES306226A1
ES306226A1 ES0306226A ES306226A ES306226A1 ES 306226 A1 ES306226 A1 ES 306226A1 ES 0306226 A ES0306226 A ES 0306226A ES 306226 A ES306226 A ES 306226A ES 306226 A1 ES306226 A1 ES 306226A1
Authority
ES
Spain
Prior art keywords
formula
group
compounds
pyrimidine
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0306226A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ECHERCHE MEDICALE SCIENCE UNIO
Original Assignee
ECHERCHE MEDICALE SCIENCE UNIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ECHERCHE MEDICALE SCIENCE UNIO filed Critical ECHERCHE MEDICALE SCIENCE UNIO
Publication of ES306226A1 publication Critical patent/ES306226A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES0306226A 1963-11-19 1964-11-19 Procedimiento de preparaciën de nuevos derivados de la pirimidina Expired ES306226A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45685/63A GB1101425A (en) 1963-11-19 1963-11-19 New pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ES306226A1 true ES306226A1 (es) 1965-03-01

Family

ID=10438157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0306226A Expired ES306226A1 (es) 1963-11-19 1964-11-19 Procedimiento de preparaciën de nuevos derivados de la pirimidina

Country Status (14)

Country Link
US (1) US3299067A (en, 2012)
AT (1) AT255421B (en, 2012)
BE (1) BE655431A (en, 2012)
BR (1) BR6464358D0 (en, 2012)
CH (1) CH437310A (en, 2012)
DE (1) DE1297610B (en, 2012)
DK (1) DK115995B (en, 2012)
ES (1) ES306226A1 (en, 2012)
FI (1) FI46163C (en, 2012)
FR (1) FR4770M (en, 2012)
GB (1) GB1101425A (en, 2012)
NL (2) NL6413349A (en, 2012)
NO (1) NO115800B (en, 2012)
SE (1) SE322521B (en, 2012)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US3980781A (en) * 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
GB1369379A (en) * 1972-04-07 1974-10-09 Science Union & Cie Benzodioxole derivatives and processes for preparing them
US3919230A (en) * 1974-02-07 1975-11-11 Smithkline Corp {62 -Naphthylmethyl piperazinyl derivatives
US3988457A (en) * 1974-02-07 1976-10-26 Smithkline Corporation Novel compounds and compositions for treating Parkinson's disease
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
OA06083A (fr) * 1977-11-09 1981-06-30 Science Union & Cie Ste Franca Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant.
FR2519986A1 (fr) * 1982-01-21 1983-07-22 Adir Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
FR2539990A1 (fr) * 1983-01-28 1984-08-03 Sanofi Sa Composition pharmaceutique a action psychotrope dopaminergique contenant une 2-piperazinopyrimidine
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4980350A (en) * 1988-02-25 1990-12-25 Merck & Co., Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5859246A (en) * 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
KR20010040254A (ko) * 1997-09-29 2001-05-15 스티븐 엘. 네스빗 아미노알킬페놀 유도체 및 관련 화합물
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
DE60336485D1 (de) 2002-08-19 2011-05-05 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
EP1727806A1 (en) * 2004-01-16 2006-12-06 Novartis AG 2,4-diaminopyrimidines and their use for inducing cardiomyogenesis
US7241891B2 (en) * 2004-03-29 2007-07-10 Chung-Shan Institute Of Science & Technology Method for the purification of Piribedil
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN101735201B (zh) * 2009-12-17 2012-05-30 宁夏康亚药业有限公司 一种吡贝地尔的制备方法
CN101830891A (zh) * 2010-05-18 2010-09-15 沈阳药科大学 一种吡贝地尔的制备方法
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US10336775B2 (en) 2014-08-28 2019-07-02 Asceneuron Sa Glycosidase inhibitors
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
KR20180132629A (ko) 2016-02-25 2018-12-12 아셰뉴론 에스아 글리코시다제 저해제
EP3419976B1 (en) 2016-02-25 2021-04-07 Asceneuron SA Acid addition salts of piperazine derivatives
JP2019506430A (ja) 2016-02-25 2019-03-07 エースニューロン・ソシエテ・アノニム グリコシダーゼ阻害剤
CN106432212B (zh) * 2016-09-21 2019-01-11 苏州弘森药业股份有限公司 一种合成吡贝地尔的方法
SG11201907774VA (en) 2017-02-24 2019-09-27 Asceneuron S A Sulfoximine glycosidase inhibitors
CN107266429A (zh) * 2017-06-19 2017-10-20 太仓大唐化纤厂 一种高品质的吡贝地尔制备方法
CN107216318A (zh) * 2017-06-19 2017-09-29 太仓弘杉环保科技有限公司 一种吡贝地尔制备方法
CN107163032A (zh) * 2017-06-19 2017-09-15 太仓卡斯特姆新材料有限公司 一种高收率的吡贝地尔制备方法
CN107417674B (zh) * 2017-06-26 2020-12-29 苏州弘森药业股份有限公司 一种吡贝地尔的提纯方法
EP3672959A1 (en) 2017-08-24 2020-07-01 Asceneuron SA Linear glycosidase inhibitors
WO2019037861A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. ANNOTATED GLYCOSIDASE INHIBITORS
RU2737721C2 (ru) * 2017-12-15 2020-12-02 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе пирибедила
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
EA202190275A1 (ru) 2018-08-22 2021-08-02 Асенейрон С. А. Сукцинатные и фумаратные кислотно-аддитивные соли производных пиперазина, пригодные в качестве ингибиторов гликозидазы
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
US20220143042A1 (en) 2019-02-22 2022-05-12 Asceneuron Sa Fused glycosidase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL72956C (en, 2012) * 1947-11-12
DE942029C (de) * 1951-06-22 1956-04-26 American Cyanamid Co Verfahren zur Herstellung von neuen, in 1-Stellung substituierten 4-Aminopiperazinderivaten
US3078214A (en) * 1958-09-12 1963-02-19 Sandoz Ag Treatment of mental disturbances with esters of indoles
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US3141820A (en) * 1960-10-31 1964-07-21 Merck & Co Inc Coccidiosis control composition
BE618035A (en, 2012) * 1961-05-26
US3144387A (en) * 1961-06-30 1964-08-11 Parke Davis & Co Anti-inflammatory compositions

Also Published As

Publication number Publication date
DE1297610B (de) 1969-06-19
NO115800B (en, 2012) 1968-12-09
FR4770M (en, 2012) 1967-01-23
DK115995B (da) 1969-12-01
AT255421B (de) 1967-07-10
US3299067A (en) 1967-01-17
BR6464358D0 (pt) 1973-07-26
FI46163B (en, 2012) 1972-10-02
NL127996C (en, 2012)
CH437310A (fr) 1967-06-15
NL6413349A (en, 2012) 1965-05-20
SE322521B (en, 2012) 1970-04-13
GB1101425A (en) 1968-01-31
FI46163C (fi) 1973-01-10
BE655431A (en, 2012) 1965-05-06

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