ES2983444T3 - Tratamiento de células madre en patologías endometriales - Google Patents

Tratamiento de células madre en patologías endometriales Download PDF

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Publication number
ES2983444T3
ES2983444T3 ES22150013T ES22150013T ES2983444T3 ES 2983444 T3 ES2983444 T3 ES 2983444T3 ES 22150013 T ES22150013 T ES 22150013T ES 22150013 T ES22150013 T ES 22150013T ES 2983444 T3 ES2983444 T3 ES 2983444T3
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Spain
Prior art keywords
bmdscs
subject
endometrial
isolated
cells
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ES22150013T
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English (en)
Spanish (es)
Inventor
Carlos Simon
Javier Santamaria
Antonio Pellicer
Irene Cervello
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Asherman Therapy S L
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Asherman Therapy S L
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
ES22150013T 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales Active ES2983444T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462013121P 2014-06-17 2014-06-17

Publications (1)

Publication Number Publication Date
ES2983444T3 true ES2983444T3 (es) 2024-10-23

Family

ID=54329860

Family Applications (3)

Application Number Title Priority Date Filing Date
ES22150013T Active ES2983444T3 (es) 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales
ES19169309T Active ES2910306T3 (es) 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales
ES15781411T Active ES2736117T3 (es) 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES19169309T Active ES2910306T3 (es) 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales
ES15781411T Active ES2736117T3 (es) 2014-06-17 2015-06-05 Tratamiento de células madre en patologías endometriales

Country Status (22)

Country Link
US (1) US11129851B2 (enExample)
EP (3) EP3158057B1 (enExample)
JP (2) JP6920062B2 (enExample)
CN (2) CN116747241A (enExample)
AU (1) AU2015275798B2 (enExample)
BR (1) BR112016029558A2 (enExample)
CA (1) CA2952559C (enExample)
CY (2) CY1122615T1 (enExample)
DK (2) DK3158057T3 (enExample)
ES (3) ES2983444T3 (enExample)
HR (3) HRP20240798T1 (enExample)
HU (3) HUE058328T2 (enExample)
LT (2) LT3158057T (enExample)
MX (1) MX377300B (enExample)
PL (3) PL3158057T3 (enExample)
PT (2) PT3158057T (enExample)
RS (3) RS63093B1 (enExample)
RU (1) RU2725006C2 (enExample)
SI (2) SI3158057T1 (enExample)
SM (3) SMT202400270T1 (enExample)
TR (1) TR201910410T4 (enExample)
WO (1) WO2015193737A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
KR102226219B1 (ko) 2012-06-06 2021-03-10 펀다시오 인스티튜트 드 르세르카 바이오메디카 (아이알비 바르셀로나) 폐암 전이의 진단, 예후 및 치료 방법
JP6074049B2 (ja) 2012-10-12 2017-02-01 インバイオモーション エセ.エレ. c−MAFを用いた前立腺がん転移の診断、予後診断および処置のための方法
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
US20140314792A1 (en) 2013-03-15 2014-10-23 Institució Catalana De Recerca I Estudis Avançats Method for the diagnosis, prognosis and treatment of cancer metastasis
HUE058328T2 (hu) 2014-06-17 2022-07-28 Asherman Therapy S L Õssejtterápia endometriális patológiás állapotokban
AU2017281631B2 (en) * 2016-06-23 2023-06-15 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
RU2699029C1 (ru) * 2018-12-10 2019-09-03 Частное образовательное учреждение дополнительного профессионального образования "Академия медицинского образования имени Федора Ивановича Иноземцева" (ЧОУ ДПО "Академия медицинского образования им. Ф.И. Иноземцева") Способ использования мезенхимальных стволовых клеток для улучшения состояния рубца на матке
RU2741621C1 (ru) * 2020-09-25 2021-01-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Способ лечения внутриматочных синехий
CN117979980A (zh) 2021-07-23 2024-05-03 车医科学大学校产学协力团 用于预防或治疗阿谢曼综合征的包含分离的线粒体作为活性成分的药物组合物

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013299A1 (en) 1989-05-05 1990-11-15 Northern Sydney Area Health Service Fertility enhancement
US6979533B2 (en) 1992-06-12 2005-12-27 The Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation
CA2203718A1 (en) 1997-04-25 1998-10-25 University Of British Columbia Cadherin-11 as an indicator of viable pregnancy
IL127896A0 (en) 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
AU2001240096A1 (en) 2000-03-08 2001-09-17 Rebecca L. Dubowy Methods of diagnosing and monitoring endometrial glandular development
JP2004504275A (ja) 2000-05-24 2004-02-12 シエーリング アクチエンゲゼルシャフト フィブリン−1の医薬用途
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
AUPR673001A0 (en) 2001-07-31 2001-08-23 Prince Henry's Institute Of Medical Research Pregnancy-related enzyme activity
DE10139874A1 (de) 2001-08-10 2003-04-30 Schering Ag Humane Mater-Proteine
GB0201284D0 (en) 2002-01-21 2002-03-06 Isis Innovation Screening methods for contraceptive and fertility agents
US20030186300A1 (en) 2002-03-20 2003-10-02 Ali Akoum Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment of related conditions
EP1511863A4 (en) 2002-05-14 2006-12-27 Univ Leland Stanford Junior ENDOMETRIAL GENES FOR THE DETECTION OF ENDOMETRIAL DISORDERS
WO2004014935A1 (de) 2002-08-02 2004-02-19 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
EP1579007B1 (de) 2002-12-21 2015-05-27 Universität Leipzig Verfahren und mittel zur bestimmung von bestimmten zuständen bzw. veränderungen im uterusepithel und im epithel anderer organe
US20060286555A1 (en) 2003-08-21 2006-12-21 Van Beuningen Marinus G J Microarray support for bioprobe synthesis
CN1863905A (zh) 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物
WO2005026324A2 (en) 2003-09-08 2005-03-24 The Board Of Regents Of The University Of Texas System Method and composition for enhancing in vitro embryo development by supplementing culture medium with prostaglandin or a prostaglandin analog
US20080226554A1 (en) 2003-12-23 2008-09-18 Mount Sinai Hospital Methods For Detecting Markers Associated With Endometrial Disease or Phase
EP1765083A4 (en) 2004-05-28 2008-08-20 Serono Lab USE OF IL-17 TO TREAT FERTILITY DISORDERS
US20090111140A1 (en) * 2006-03-31 2009-04-30 Koninklijke Philips Electronics N.V. Systems and methods for cell measurement utilizing ultrashort t2*
JP2007278750A (ja) 2006-04-04 2007-10-25 Ono Pharmaceut Co Ltd プロスタグランジン類及びその類縁体の定量方法
US20120269774A1 (en) * 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
GB0703683D0 (en) * 2007-02-26 2007-04-04 Ark Therapeutics Ltd The treatment of complications in pregnancy
US9259233B2 (en) * 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8673850B2 (en) 2008-05-30 2014-03-18 Institut De Recherches Cliniques De Montreal PCSK9 inhibitors and methods of use thereof
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
WO2013166281A1 (en) * 2012-05-02 2013-11-07 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
EP2348318A1 (en) 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
EP2768976B1 (en) 2011-10-21 2018-01-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for assessing endometrial receptivity of a patient after controlled ovarian hyperstimulation
US9423402B2 (en) 2011-11-30 2016-08-23 Singapore Health Services Pte. Ltd. GM1 ganglioside to annexin V microparticle polypeptide ratio for biological monitoring
BR112014029233A8 (pt) 2012-06-27 2019-01-29 Hoffmann La Roche método para diagnosticar se um indivíduo grávido não está em risco, usos de pelo menos um dos biomarcadores sfit-1, endoglina e pigf, dispositivo, kit, método de gestão de um indivíduo, sistema e método para estabelecer um auxílio
RU2515475C1 (ru) * 2012-11-15 2014-05-10 Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте
WO2015166353A2 (en) 2014-03-21 2015-11-05 Equipo I. V. I. Investigacion S.L. Early detection of preeclampsia
HUE058328T2 (hu) 2014-06-17 2022-07-28 Asherman Therapy S L Õssejtterápia endometriális patológiás állapotokban

Also Published As

Publication number Publication date
US11129851B2 (en) 2021-09-28
MX2016016756A (es) 2017-11-02
US20170128492A1 (en) 2017-05-11
PT3569697T (pt) 2022-05-02
HRP20220419T1 (hr) 2022-05-27
CA2952559A1 (en) 2015-12-23
SMT202400270T1 (it) 2024-07-09
EP3158057B1 (en) 2019-04-17
JP2020138984A (ja) 2020-09-03
EP4012023C0 (en) 2024-05-15
RS59210B1 (sr) 2019-10-31
PL3158057T3 (pl) 2020-05-18
ES2910306T3 (es) 2022-05-12
RU2017101147A (ru) 2018-07-17
CY1125938T1 (el) 2024-02-16
JP2017522288A (ja) 2017-08-10
SMT202200155T1 (it) 2022-05-12
LT3569697T (lt) 2022-04-25
HUE044823T2 (hu) 2019-11-28
PT3158057T (pt) 2019-07-19
RS65719B1 (sr) 2024-08-30
EP4012023A1 (en) 2022-06-15
WO2015193737A1 (en) 2015-12-23
AU2015275798A1 (en) 2017-02-02
EP4012023B1 (en) 2024-05-15
MX377300B (es) 2025-03-07
LT3158057T (lt) 2019-09-25
EP3569697A1 (en) 2019-11-20
EP3569697B8 (en) 2022-04-27
AU2015275798B2 (en) 2021-03-25
RS63093B1 (sr) 2022-04-29
HUE058328T2 (hu) 2022-07-28
HRP20191240T1 (hr) 2019-11-01
SI3158057T1 (sl) 2019-10-30
SI3569697T1 (sl) 2022-05-31
RU2725006C2 (ru) 2020-06-29
DK3569697T3 (da) 2022-04-04
CA2952559C (en) 2023-01-24
HRP20240798T1 (hr) 2024-09-27
CN107073040A (zh) 2017-08-18
DK3158057T3 (da) 2019-07-29
CN116747241A (zh) 2023-09-15
CY1122615T1 (el) 2021-03-12
TR201910410T4 (tr) 2019-08-21
RU2017101147A3 (enExample) 2019-02-06
SMT201900400T1 (it) 2019-09-09
PL3569697T3 (pl) 2022-07-04
BR112016029558A2 (pt) 2017-08-22
HUE067463T2 (hu) 2024-10-28
ES2736117T3 (es) 2019-12-26
EP3158057A1 (en) 2017-04-26
JP6920062B2 (ja) 2021-08-18
EP3569697B1 (en) 2022-01-05
PL4012023T3 (pl) 2024-09-02

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