CN116747241A - 子宫内膜病理状况中的干细胞治疗 - Google Patents

子宫内膜病理状况中的干细胞治疗 Download PDF

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Publication number
CN116747241A
CN116747241A CN202310575540.1A CN202310575540A CN116747241A CN 116747241 A CN116747241 A CN 116747241A CN 202310575540 A CN202310575540 A CN 202310575540A CN 116747241 A CN116747241 A CN 116747241A
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endometrial
bmdsc
subject
uterine
cells
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Chinese (zh)
Inventor
卡洛斯·西蒙
哈维尔·圣玛丽亚
安东尼奥·佩利塞尔
伊雷妮·切尔韦洛
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Equipo IVI Investigacion SL
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Equipo IVI Investigacion SL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
CN202310575540.1A 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗 Pending CN116747241A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462013121P 2014-06-17 2014-06-17
US62/013,121 2014-06-17
CN201580043147.1A CN107073040A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗
PCT/IB2015/001715 WO2015193737A1 (en) 2014-06-17 2015-06-05 Stem cell therapy in endometrial pathologies

Related Parent Applications (1)

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CN201580043147.1A Division CN107073040A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

Publications (1)

Publication Number Publication Date
CN116747241A true CN116747241A (zh) 2023-09-15

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CN202310575540.1A Pending CN116747241A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗
CN201580043147.1A Pending CN107073040A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

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US (1) US11129851B2 (enExample)
EP (3) EP3158057B1 (enExample)
JP (2) JP6920062B2 (enExample)
CN (2) CN116747241A (enExample)
AU (1) AU2015275798B2 (enExample)
BR (1) BR112016029558A2 (enExample)
CA (1) CA2952559C (enExample)
CY (2) CY1122615T1 (enExample)
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ES (3) ES2736117T3 (enExample)
HR (3) HRP20191240T1 (enExample)
HU (3) HUE067463T2 (enExample)
LT (2) LT3569697T (enExample)
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PL (3) PL4012023T3 (enExample)
PT (2) PT3158057T (enExample)
RS (3) RS59210B1 (enExample)
RU (1) RU2725006C2 (enExample)
SI (2) SI3158057T1 (enExample)
SM (3) SMT201900400T1 (enExample)
TR (1) TR201910410T4 (enExample)
WO (1) WO2015193737A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
ES2705237T3 (es) 2012-06-06 2019-03-22 Fundacio Inst De Recerca Biomedica Irb Barcelona Método para el diagnóstico y el pronóstico de metástasis del cáncer de pulmón
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
DK2906718T3 (da) 2012-10-12 2019-07-01 Inbiomotion Sl Fremgangsmåde til diagnose, prognose og behandling af prostatakræftmetastase under anvendelse af c-maf
BR112015023510A2 (pt) 2013-03-15 2017-10-10 Fundacio Inst De Recerca Biomedica Irb Barcelona método para o diagnóstico, prognóstico e tratamento de câncer metastático
ES2736117T3 (es) 2014-06-17 2019-12-26 Igenomix S L Tratamiento de células madre en patologías endometriales
WO2017223233A1 (en) * 2016-06-23 2017-12-28 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
RU2699029C1 (ru) * 2018-12-10 2019-09-03 Частное образовательное учреждение дополнительного профессионального образования "Академия медицинского образования имени Федора Ивановича Иноземцева" (ЧОУ ДПО "Академия медицинского образования им. Ф.И. Иноземцева") Способ использования мезенхимальных стволовых клеток для улучшения состояния рубца на матке
RU2741621C1 (ru) * 2020-09-25 2021-01-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Способ лечения внутриматочных синехий
CN117979980A (zh) 2021-07-23 2024-05-03 车医科学大学校产学协力团 用于预防或治疗阿谢曼综合征的包含分离的线粒体作为活性成分的药物组合物

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69027992D1 (de) 1989-05-05 1996-09-05 North Sydney Area Health Serv Steigerung der fruchtbarkeit
US6979533B2 (en) 1992-06-12 2005-12-27 The Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation
CA2203718A1 (en) 1997-04-25 1998-10-25 University Of British Columbia Cadherin-11 as an indicator of viable pregnancy
IL127896A0 (en) 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
EP1255851A4 (en) 2000-03-08 2004-03-31 Harvey J Kliman METHODS FOR DIAGNOSING AND MONITORING ENDOMETRIAL GLANDULAR DEVELOPMENT
EP1301195A2 (en) 2000-05-24 2003-04-16 Schering Aktiengesellschaft Pharmaceutical use of fibulin-1
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
AUPR673001A0 (en) 2001-07-31 2001-08-23 Prince Henry's Institute Of Medical Research Pregnancy-related enzyme activity
DE10139874A1 (de) 2001-08-10 2003-04-30 Schering Ag Humane Mater-Proteine
GB0201284D0 (en) 2002-01-21 2002-03-06 Isis Innovation Screening methods for contraceptive and fertility agents
US20030186300A1 (en) 2002-03-20 2003-10-02 Ali Akoum Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment of related conditions
US20040005612A1 (en) 2002-05-14 2004-01-08 Giudice Linda C. Endometrial genes in endometrial disorders
ES2273061T3 (es) 2002-08-02 2007-05-01 Schering Aktiengesellschaft Agentes moduladores de receptores de progesterona con actividad antigonadotropa elevada para el control de fertilidad femenina y para la terapia por reemplazo hormonal.
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
EP1579007B1 (de) 2002-12-21 2015-05-27 Universität Leipzig Verfahren und mittel zur bestimmung von bestimmten zuständen bzw. veränderungen im uterusepithel und im epithel anderer organe
EP1660228A1 (en) 2003-08-21 2006-05-31 PamGene B.V. Microarray support for bioprobe synthesis
WO2005026324A2 (en) 2003-09-08 2005-03-24 The Board Of Regents Of The University Of Texas System Method and composition for enhancing in vitro embryo development by supplementing culture medium with prostaglandin or a prostaglandin analog
CN1863905A (zh) 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物
WO2005061725A1 (en) 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
AU2005249504A1 (en) 2004-05-28 2005-12-15 Laboratoires Serono Sa Use of IL-17 in the treatment of fertility-related disorders
CN101460199B (zh) * 2006-03-31 2011-06-08 皇家飞利浦电子股份有限公司 利用超短t2*弛豫进行细胞测量的系统和方法
JP2007278750A (ja) 2006-04-04 2007-10-25 Ono Pharmaceut Co Ltd プロスタグランジン類及びその類縁体の定量方法
US20120269774A1 (en) * 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
GB0703683D0 (en) * 2007-02-26 2007-04-04 Ark Therapeutics Ltd The treatment of complications in pregnancy
US9259233B2 (en) * 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
WO2009143633A1 (en) 2008-05-30 2009-12-03 Institut De Recherches Cliniques De Montreal Pcsk9 inhibitors and methods of use thereof
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
WO2013166281A1 (en) * 2012-05-02 2013-11-07 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
EP2348318A1 (en) 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
ES2662571T3 (es) 2011-10-21 2018-04-09 Institut National De La Santé Et De La Recherche Médicale (Inserm) Métodos de evaluación de la receptividad endometrial de una paciente tras una hiperestimulación ovárica controlada
AU2012346594B2 (en) 2011-11-30 2017-12-21 Agency For Science, Technology And Research GM1 ganglioside to Annexin V microparticle polypeptide ratio for biological monitoring
CN104412107B (zh) 2012-06-27 2018-06-08 弗·哈夫曼-拉罗切有限公司 用sFlt-1/PlGF或内皮糖蛋白/PlGF比值来排除先兆子痫在某时期内发病的手段和方法
RU2515475C1 (ru) * 2012-11-15 2014-05-10 Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте
CA2943284A1 (en) 2014-03-21 2015-11-05 Igenomix S.L. Early detection of preeclampsia
ES2736117T3 (es) 2014-06-17 2019-12-26 Igenomix S L Tratamiento de células madre en patologías endometriales

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HRP20240798T1 (hr) 2024-09-27
HUE044823T2 (hu) 2019-11-28
SMT202200155T1 (it) 2022-05-12
AU2015275798A1 (en) 2017-02-02
RS59210B1 (sr) 2019-10-31
WO2015193737A1 (en) 2015-12-23
JP2017522288A (ja) 2017-08-10
CY1122615T1 (el) 2021-03-12
EP4012023A1 (en) 2022-06-15
SI3158057T1 (sl) 2019-10-30
PL4012023T3 (pl) 2024-09-02
LT3158057T (lt) 2019-09-25
PL3569697T3 (pl) 2022-07-04
RS65719B1 (sr) 2024-08-30
SMT201900400T1 (it) 2019-09-09
EP3158057A1 (en) 2017-04-26
JP2020138984A (ja) 2020-09-03
JP6920062B2 (ja) 2021-08-18
EP3158057B1 (en) 2019-04-17
DK3158057T3 (da) 2019-07-29
MX2016016756A (es) 2017-11-02
US11129851B2 (en) 2021-09-28
HRP20220419T1 (hr) 2022-05-27
PL3158057T3 (pl) 2020-05-18
ES2910306T3 (es) 2022-05-12
RU2725006C2 (ru) 2020-06-29
PT3569697T (pt) 2022-05-02
RS63093B1 (sr) 2022-04-29
TR201910410T4 (tr) 2019-08-21
ES2983444T3 (es) 2024-10-23
EP3569697B8 (en) 2022-04-27
RU2017101147A (ru) 2018-07-17
DK3569697T3 (da) 2022-04-04
SMT202400270T1 (it) 2024-07-09
EP4012023C0 (en) 2024-05-15
AU2015275798B2 (en) 2021-03-25
HRP20191240T1 (hr) 2019-11-01
EP4012023B1 (en) 2024-05-15
CY1125938T1 (el) 2024-02-16
HUE067463T2 (hu) 2024-10-28
EP3569697A1 (en) 2019-11-20
RU2017101147A3 (enExample) 2019-02-06
PT3158057T (pt) 2019-07-19
US20170128492A1 (en) 2017-05-11
MX377300B (es) 2025-03-07
BR112016029558A2 (pt) 2017-08-22
EP3569697B1 (en) 2022-01-05
CA2952559A1 (en) 2015-12-23
LT3569697T (lt) 2022-04-25
SI3569697T1 (sl) 2022-05-31
ES2736117T3 (es) 2019-12-26
CA2952559C (en) 2023-01-24
HUE058328T2 (hu) 2022-07-28
CN107073040A (zh) 2017-08-18

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