HRP20191240T1 - Terapija matičnim stanicama kod patologija endometrija - Google Patents
Terapija matičnim stanicama kod patologija endometrija Download PDFInfo
- Publication number
- HRP20191240T1 HRP20191240T1 HRP20191240T HRP20191240T1 HR P20191240 T1 HRP20191240 T1 HR P20191240T1 HR P20191240 T HRP20191240 T HR P20191240T HR P20191240 T1 HRP20191240 T1 HR P20191240T1
- Authority
- HR
- Croatia
- Prior art keywords
- bmdscs
- isolated
- subject
- use according
- administered
- Prior art date
Links
- 230000002357 endometrial effect Effects 0.000 title 1
- 230000007170 pathology Effects 0.000 title 1
- 238000009168 stem cell therapy Methods 0.000 title 1
- 238000009580 stem-cell therapy Methods 0.000 title 1
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 206010051909 Endometrial atrophy Diseases 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 238000002617 apheresis Methods 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000001483 mobilizing effect Effects 0.000 claims 2
- 210000000685 uterine artery Anatomy 0.000 claims 2
- 208000002777 Gynatresia Diseases 0.000 claims 1
- 210000002565 arteriole Anatomy 0.000 claims 1
- 230000032692 embryo implantation Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Claims (9)
1. Izolirane autologne matične stanice CD133+ dobivene iz koštane srži (BMDSC) za uporabu u liječenju Ashermanovog sindroma ili atrofije endometrija kod subjekta kojem je to potrebno, naznačene time što se izolirane CD133+ BMDSC daju u arterije maternice subjekta.
2. Izolirane CD133+ BMDSC za uporabu prema patentnom zahtjevu 1, naznačene time što subjekt ima atrofiju endometrija koja je rezistentna na hormonsko liječenje.
3. Izolirane CD133+ BMDSC za uporabu prema patentnom zahtjevu 1 ili zahtjevu 2, naznačene time što subjekt ima jednu ili više prethodnih neuspjelih implantacija embrija.
4. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 1-3, naznačene time što izolirane autologne CD133+ BMDSC izolirane iz periferne krvi subjekta nakon primjene na subjekta sredstva za mobilizaciju BMDSC iz koštane srži u perifernu krv subjekta.
5. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 1-4, naznačene time što sredstvo za mobilizaciju BMDSC je faktor stimulacije kolonije granulocita (G-CSF).
6. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 1-5, naznačene time što se CD133+ BMDSC daju u arterije maternice kroz kateter.
7. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 1-6, naznačene time što se CD133+ BMDSC daju u maternične spiralne arteriole subjekta.
8. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 4-7, naznačene time što su autologne CD133+ BMDSC izolirane iz periferne krvi subjekta pomoću afereze i pri čemu je afereza izvedena korištenjem anti-CD133 protutijela.
9. Izolirane CD133+ BMDSC za uporabu prema bilo kojem od patentnih zahtjeva 1-8, naznačene time što se subjektu daje barem 45 milijuna CD133+ BMDSC.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462013121P | 2014-06-17 | 2014-06-17 | |
| PCT/IB2015/001715 WO2015193737A1 (en) | 2014-06-17 | 2015-06-05 | Stem cell therapy in endometrial pathologies |
| EP15781411.2A EP3158057B1 (en) | 2014-06-17 | 2015-06-05 | Stem cell therapy in endometrial pathologies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191240T1 true HRP20191240T1 (hr) | 2019-11-01 |
Family
ID=54329860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220419TT HRP20220419T1 (hr) | 2014-06-17 | 2015-06-05 | Terapija matičnim stanicama kod patologija endometrija |
| HRP20191240 HRP20191240T1 (hr) | 2014-06-17 | 2019-07-11 | Terapija matičnim stanicama kod patologija endometrija |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220419TT HRP20220419T1 (hr) | 2014-06-17 | 2015-06-05 | Terapija matičnim stanicama kod patologija endometrija |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11129851B2 (hr) |
| EP (3) | EP3569697B8 (hr) |
| JP (2) | JP6920062B2 (hr) |
| CN (2) | CN116747241A (hr) |
| AU (1) | AU2015275798B2 (hr) |
| BR (1) | BR112016029558A2 (hr) |
| CA (1) | CA2952559C (hr) |
| CY (2) | CY1122615T1 (hr) |
| DK (2) | DK3569697T3 (hr) |
| ES (2) | ES2736117T3 (hr) |
| HR (2) | HRP20220419T1 (hr) |
| HU (2) | HUE058328T2 (hr) |
| LT (2) | LT3569697T (hr) |
| MX (1) | MX2016016756A (hr) |
| PL (2) | PL3158057T3 (hr) |
| PT (2) | PT3569697T (hr) |
| RS (2) | RS63093B1 (hr) |
| RU (1) | RU2725006C2 (hr) |
| SI (2) | SI3569697T1 (hr) |
| TR (1) | TR201910410T4 (hr) |
| WO (1) | WO2015193737A1 (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010010201A1 (es) | 2008-07-22 | 2010-01-28 | Equipo Ivi Investigacion Sl | Perfil de expresion genetica como marcador de la receptividad endometrial |
| EP2859120B1 (en) | 2012-06-06 | 2018-11-14 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the diagnosis and prognosis of lung cancer metastasis |
| ES2744244T3 (es) | 2012-10-12 | 2020-02-24 | Inbiomotion Sl | Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata usando c-MAF |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| EP3272880B1 (en) | 2013-03-15 | 2020-11-25 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the diagnosis, prognosis and treatment of metastatic cancer |
| WO2015193737A1 (en) | 2014-06-17 | 2015-12-23 | Igenomix S.L. | Stem cell therapy in endometrial pathologies |
| WO2017223233A1 (en) * | 2016-06-23 | 2017-12-28 | Tithon Biotech, Inc. | Cells expressing parathyroid hormone 1 receptor and uses thereof |
| RU2699029C1 (ru) * | 2018-12-10 | 2019-09-03 | Частное образовательное учреждение дополнительного профессионального образования "Академия медицинского образования имени Федора Ивановича Иноземцева" (ЧОУ ДПО "Академия медицинского образования им. Ф.И. Иноземцева") | Способ использования мезенхимальных стволовых клеток для улучшения состояния рубца на матке |
| RU2741621C1 (ru) * | 2020-09-25 | 2021-01-28 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Способ лечения внутриматочных синехий |
| WO2023003130A1 (ko) | 2021-07-23 | 2023-01-26 | 차의과학대학교 산학협력단 | 분리된 미토콘드리아를 유효성분으로 포함하는 아셔만 증후군 예방 또는 치료용 약학 조성물 |
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| US6979533B2 (en) | 1992-06-12 | 2005-12-27 | The Trustees Of The University Of Pennsylvania | Determination of endometrial receptivity toward embryo implantation |
| CA2203718A1 (en) | 1997-04-25 | 1998-10-25 | University Of British Columbia | Cadherin-11 as an indicator of viable pregnancy |
| IL127896A0 (en) | 1998-12-31 | 1999-10-28 | Gail Laster | A novel treatment for preeclampsia and related diseases |
| US6733962B2 (en) | 2000-03-08 | 2004-05-11 | Harvey J. Kliman | Methods of diagnosing and monitoring endometrial glandular development |
| WO2001089548A2 (en) | 2000-05-24 | 2001-11-29 | Schering Aktiengesellschaft | Pharmaceutical use of fibulin-1 |
| US6780594B2 (en) | 2000-09-25 | 2004-08-24 | Schering Aktiengesellschaft | Method for in vitro diagnosis of endometriosis |
| AUPR673001A0 (en) | 2001-07-31 | 2001-08-23 | Prince Henry's Institute Of Medical Research | Pregnancy-related enzyme activity |
| DE10139874A1 (de) | 2001-08-10 | 2003-04-30 | Schering Ag | Humane Mater-Proteine |
| GB0201284D0 (en) | 2002-01-21 | 2002-03-06 | Isis Innovation | Screening methods for contraceptive and fertility agents |
| US20030186300A1 (en) | 2002-03-20 | 2003-10-02 | Ali Akoum | Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment of related conditions |
| CA2489568A1 (en) | 2002-05-14 | 2004-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Endometrial genes in endometrial disorders |
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| AU2003303347A1 (en) | 2002-12-21 | 2004-07-22 | Universitat Leipzig | Method and means for determining specific conditions or changes in the uterine epithelium and in the epithelium of other organs |
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| EP1670902A4 (en) | 2003-09-08 | 2008-05-07 | Univ Texas | METHOD AND COMPOSITION FOR ENHANCING IN VITRO EMBRYONIC DEVELOPMENT BY ENRICHING A CULTURE MEDIUM COMPRISING PROSTAGLANDIN OR PROSTAGLANDIN ANALOGUE |
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| WO2009143633A1 (en) | 2008-05-30 | 2009-12-03 | Institut De Recherches Cliniques De Montreal | Pcsk9 inhibitors and methods of use thereof |
| WO2010010201A1 (es) | 2008-07-22 | 2010-01-28 | Equipo Ivi Investigacion Sl | Perfil de expresion genetica como marcador de la receptividad endometrial |
| WO2013166281A1 (en) * | 2012-05-02 | 2013-11-07 | Cedars-Sinai Medical Center | Bi-functional compositions for targeting cells to diseased tissues and methods of using same |
| EP2348318A1 (en) | 2010-01-21 | 2011-07-27 | Equipo Ivi Investigación, S.L. | Diagnostic method for endometrial receptivity |
| PT2768976T (pt) | 2011-10-21 | 2018-04-05 | Inst Nat Sante Rech Med | Métodos para avaliar a receptividade endométrica de uma paciente após hiperestimulação ovárica controlada |
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| BR112014029233A8 (pt) | 2012-06-27 | 2019-01-29 | Hoffmann La Roche | método para diagnosticar se um indivíduo grávido não está em risco, usos de pelo menos um dos biomarcadores sfit-1, endoglina e pigf, dispositivo, kit, método de gestão de um indivíduo, sistema e método para estabelecer um auxílio |
| RU2515475C1 (ru) | 2012-11-15 | 2014-05-10 | Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК | Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте |
| US20170097358A1 (en) | 2014-03-21 | 2017-04-06 | Igenomix S.L. | Early detection of preeclampsia |
| WO2015193737A1 (en) | 2014-06-17 | 2015-12-23 | Igenomix S.L. | Stem cell therapy in endometrial pathologies |
-
2015
- 2015-06-05 WO PCT/IB2015/001715 patent/WO2015193737A1/en active Application Filing
- 2015-06-05 CA CA2952559A patent/CA2952559C/en active Active
- 2015-06-05 PL PL15781411T patent/PL3158057T3/pl unknown
- 2015-06-05 US US15/318,825 patent/US11129851B2/en active Active
- 2015-06-05 DK DK19169309.2T patent/DK3569697T3/da active
- 2015-06-05 DK DK15781411.2T patent/DK3158057T3/da active
- 2015-06-05 TR TR2019/10410T patent/TR201910410T4/tr unknown
- 2015-06-05 ES ES15781411T patent/ES2736117T3/es active Active
- 2015-06-05 SI SI201531822T patent/SI3569697T1/sl unknown
- 2015-06-05 SI SI201530822T patent/SI3158057T1/sl unknown
- 2015-06-05 RS RS20220339A patent/RS63093B1/sr unknown
- 2015-06-05 EP EP19169309.2A patent/EP3569697B8/en active Active
- 2015-06-05 HR HRP20220419TT patent/HRP20220419T1/hr unknown
- 2015-06-05 BR BR112016029558A patent/BR112016029558A2/pt not_active Application Discontinuation
- 2015-06-05 HU HUE19169309A patent/HUE058328T2/hu unknown
- 2015-06-05 RS RSP20190913 patent/RS59210B1/sr unknown
- 2015-06-05 HU HUE15781411 patent/HUE044823T2/hu unknown
- 2015-06-05 EP EP22150013.5A patent/EP4012023B1/en active Active
- 2015-06-05 AU AU2015275798A patent/AU2015275798B2/en active Active
- 2015-06-05 MX MX2016016756A patent/MX2016016756A/es active IP Right Grant
- 2015-06-05 JP JP2016573587A patent/JP6920062B2/ja active Active
- 2015-06-05 RU RU2017101147A patent/RU2725006C2/ru active
- 2015-06-05 LT LTEP19169309.2T patent/LT3569697T/lt unknown
- 2015-06-05 CN CN202310575540.1A patent/CN116747241A/zh active Pending
- 2015-06-05 CN CN201580043147.1A patent/CN107073040A/zh active Pending
- 2015-06-05 ES ES19169309T patent/ES2910306T3/es active Active
- 2015-06-05 PT PT191693092T patent/PT3569697T/pt unknown
- 2015-06-05 PT PT15781411T patent/PT3158057T/pt unknown
- 2015-06-05 EP EP15781411.2A patent/EP3158057B1/en active Active
- 2015-06-05 PL PL19169309T patent/PL3569697T3/pl unknown
- 2015-06-05 LT LTEP15781411.2T patent/LT3158057T/lt unknown
-
2019
- 2019-07-11 HR HRP20191240 patent/HRP20191240T1/hr unknown
- 2019-07-16 CY CY20191100753T patent/CY1122615T1/el unknown
-
2020
- 2020-06-12 JP JP2020102340A patent/JP2020138984A/ja active Pending
-
2022
- 2022-04-05 CY CY20221100258T patent/CY1125938T1/el unknown
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