BR112017005713A2 - composto da fórmula (i), método de mobilização das células-tronco hematopoiéticas (hsc) e células progenitoras endoteliais (epc) na circulação periférica, método de tratamento de lesão tecidual, câncer, doença inflamatória ou doença autoimune, e composição farmacêutica - Google Patents
composto da fórmula (i), método de mobilização das células-tronco hematopoiéticas (hsc) e células progenitoras endoteliais (epc) na circulação periférica, método de tratamento de lesão tecidual, câncer, doença inflamatória ou doença autoimune, e composição farmacêuticaInfo
- Publication number
- BR112017005713A2 BR112017005713A2 BR112017005713A BR112017005713A BR112017005713A2 BR 112017005713 A2 BR112017005713 A2 BR 112017005713A2 BR 112017005713 A BR112017005713 A BR 112017005713A BR 112017005713 A BR112017005713 A BR 112017005713A BR 112017005713 A2 BR112017005713 A2 BR 112017005713A2
- Authority
- BR
- Brazil
- Prior art keywords
- hsc
- epc
- cancer
- compound
- formula
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003511 endothelial effect Effects 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 230000001483 mobilizing effect Effects 0.000 title 1
- 230000003836 peripheral circulation Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 208000037816 tissue injury Diseases 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462053389P | 2014-09-22 | 2014-09-22 | |
US62/053,389 | 2014-09-22 | ||
PCT/US2015/051143 WO2016048861A2 (en) | 2014-09-22 | 2015-09-21 | Heterocyclic compounds and use thereof |
Publications (2)
Publication Number | Publication Date |
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BR112017005713A2 true BR112017005713A2 (pt) | 2018-01-23 |
BR112017005713B1 BR112017005713B1 (pt) | 2023-09-26 |
Family
ID=55525127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017005713-1A BR112017005713B1 (pt) | 2014-09-22 | 2015-09-21 | Composto de fórmula (i) e composição farmacêutica |
Country Status (12)
Country | Link |
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US (2) | US9862703B2 (pt) |
EP (1) | EP3197885B1 (pt) |
JP (1) | JP6615207B2 (pt) |
KR (1) | KR102509431B1 (pt) |
CN (1) | CN107207465B (pt) |
AU (1) | AU2015321654B2 (pt) |
BR (1) | BR112017005713B1 (pt) |
CA (1) | CA2962329C (pt) |
ES (1) | ES2849998T3 (pt) |
RU (1) | RU2704008C2 (pt) |
TW (1) | TWI598348B (pt) |
WO (1) | WO2016048861A2 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018208366B2 (en) * | 2017-01-10 | 2020-12-17 | National Health Research Institutes | Heterocyclic compounds and use thereof |
JP7292740B2 (ja) * | 2017-09-08 | 2023-06-19 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Enpp1阻害剤及びがんの治療のためのそれらの使用 |
WO2020060268A1 (ko) | 2018-09-20 | 2020-03-26 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체 |
CA3128044A1 (en) * | 2019-02-01 | 2020-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enpp1 inhibitors and methods of modulating immune response |
CN111138417B (zh) * | 2019-12-18 | 2021-03-23 | 浙江工业大学 | 一种三氮唑修饰的5-氟-2,4-嘧啶二胺类化合物及其应用 |
WO2024101337A1 (ja) * | 2022-11-07 | 2024-05-16 | 国立大学法人京都大学 | キナゾリン誘導体 |
Family Cites Families (14)
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JPS4936700A (pt) * | 1972-08-16 | 1974-04-05 | ||
ATE197051T1 (de) * | 1992-04-03 | 2000-11-15 | Upjohn Co | Pharmazeutisch wirksame bicyclisch heterocyclische amine |
US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
JP4936700B2 (ja) | 2005-09-29 | 2012-05-23 | Ntn株式会社 | 車輪用軸受装置およびその製造方法 |
WO2008005538A2 (en) * | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
US8338448B2 (en) * | 2008-03-28 | 2012-12-25 | Altiris Therapeutics, Inc. | Chemokine receptor modulators |
US8563715B2 (en) * | 2008-03-31 | 2013-10-22 | Zenyaku Kogyo Kabushikikaisha | Pyrimidine derivative having cell protecting effect and uses thereof |
AU2008355098B2 (en) | 2008-04-21 | 2012-11-15 | Gpcr Therapeutics, Inc | Heterocyclic compounds |
WO2010046780A2 (en) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
CN104379180A (zh) | 2012-04-10 | 2015-02-25 | 佐治亚州立大学研究基金会公司 | 用cyld抑制剂治疗中耳炎及其它病状的组合物和方法 |
JP6293765B2 (ja) | 2012-10-10 | 2018-03-14 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症および他の疾患の処置のためのピロロ[3,2−d]ピリミジン誘導体 |
WO2014074517A1 (en) | 2012-11-08 | 2014-05-15 | Emory University | Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto |
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2015
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- 2015-09-21 RU RU2017109355A patent/RU2704008C2/ru active
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2017
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JP6615207B2 (ja) | 2019-12-04 |
EP3197885A2 (en) | 2017-08-02 |
RU2017109355A3 (pt) | 2019-04-04 |
AU2015321654B2 (en) | 2019-10-31 |
EP3197885A4 (en) | 2018-02-21 |
AU2015321654A1 (en) | 2017-04-06 |
JP2017530193A (ja) | 2017-10-12 |
CN107207465A (zh) | 2017-09-26 |
TW201615637A (zh) | 2016-05-01 |
CA2962329C (en) | 2023-12-19 |
NZ730195A (en) | 2023-12-22 |
TWI598348B (zh) | 2017-09-11 |
KR102509431B1 (ko) | 2023-03-13 |
CN107207465B (zh) | 2021-09-10 |
RU2017109355A (ru) | 2018-10-24 |
US20180009786A1 (en) | 2018-01-11 |
WO2016048861A2 (en) | 2016-03-31 |
BR112017005713B1 (pt) | 2023-09-26 |
KR20170072894A (ko) | 2017-06-27 |
CA2962329A1 (en) | 2016-03-31 |
EP3197885B1 (en) | 2020-11-18 |
WO2016048861A3 (en) | 2016-09-15 |
US20160083369A1 (en) | 2016-03-24 |
US9862703B2 (en) | 2018-01-09 |
RU2704008C2 (ru) | 2019-10-23 |
US9926298B2 (en) | 2018-03-27 |
ES2849998T3 (es) | 2021-08-24 |
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