ES2972848T3 - Análogos de péptido GIP de acción prolongada - Google Patents
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- ES2972848T3 ES2972848T3 ES18728872T ES18728872T ES2972848T3 ES 2972848 T3 ES2972848 T3 ES 2972848T3 ES 18728872 T ES18728872 T ES 18728872T ES 18728872 T ES18728872 T ES 18728872T ES 2972848 T3 ES2972848 T3 ES 2972848T3
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 108020001775 protein parts Proteins 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 1
- 235000016491 selenocysteine Nutrition 0.000 description 1
- 229940055619 selenocysteine Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17173628 | 2017-05-31 | ||
| PCT/EP2018/064355 WO2018220123A1 (en) | 2017-05-31 | 2018-05-31 | Long-acting gip peptide analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2972848T3 true ES2972848T3 (es) | 2024-06-17 |
Family
ID=59021262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18728872T Active ES2972848T3 (es) | 2017-05-31 | 2018-05-31 | Análogos de péptido GIP de acción prolongada |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11572399B2 (enExample) |
| EP (2) | EP4361173A3 (enExample) |
| JP (1) | JP2020521784A (enExample) |
| KR (1) | KR102743887B1 (enExample) |
| CN (1) | CN110691788B (enExample) |
| AU (1) | AU2018276434B2 (enExample) |
| BR (1) | BR112019025195A8 (enExample) |
| ES (1) | ES2972848T3 (enExample) |
| PL (1) | PL3630806T3 (enExample) |
| WO (1) | WO2018220123A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2685987T3 (es) | 2014-09-05 | 2018-10-15 | University Of Copenhagen | Análogos de péptidos gip |
| PL3630806T3 (pl) | 2017-05-31 | 2024-05-13 | The University Of Copenhagen | Analogi peptydów gip o długotrwałym działaniu |
| CA3097939A1 (en) | 2018-05-04 | 2019-11-07 | Novo Nordisk A/S | Gip derivatives and uses thereof |
| CN113366014B (zh) | 2018-12-03 | 2025-10-21 | 安泰博医药 | 经修饰的gip肽类似物 |
| WO2023139106A2 (en) | 2022-01-18 | 2023-07-27 | Novo Nordisk A/S | Long-acting gipr antagonists |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| ATE356830T1 (de) | 1996-08-30 | 2007-04-15 | Novo Nordisk As | Glp-1 derivate |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| WO1998024464A1 (en) | 1996-12-03 | 1998-06-11 | Trustees Of Boston University | Specific antagonists for glucose-dependent insulinotropic polypeptide (gip) |
| CA2305634C (en) | 1998-01-30 | 2006-01-03 | Novo Nordisk A/S | An injection syringe |
| EP1056775B1 (en) | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| DE69918070T2 (de) | 1998-03-13 | 2005-08-25 | Novo Nordisk A/S | Stabilisierte, wässrige Glukagonlösungen, enthaltend Detergenzien |
| US6410508B1 (en) | 1998-10-07 | 2002-06-25 | Med College Georgia Res Inst | Glucose-dependent insulinotropic peptide for use as an osteotropic hormone |
| KR100452417B1 (ko) | 1998-12-07 | 2004-10-12 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | Ｇｌｐ-1의 유사체 |
| GB0404124D0 (en) * | 2004-02-25 | 2004-03-31 | Univ Ulster | Antagonists of GIP |
| US6921748B1 (en) | 1999-03-29 | 2005-07-26 | Uutech Limited | Analogs of gastric inhibitory polypeptide and their use for treatment of diabetes |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| MXPA03005036A (es) | 2000-12-07 | 2003-09-05 | Lilly Co Eli | Proteinas de fusion glp-1. |
| US20030232761A1 (en) | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
| US20050059605A1 (en) | 2003-01-31 | 2005-03-17 | Krishna Peri | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
| MX2007009760A (es) | 2005-02-11 | 2007-11-07 | Amylin Pharmaceuticals Inc | Polipeptidos del analogo e hibrido del peptido inhibidor gastrico con propiedades seleccionables. |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| EP2004238A2 (en) | 2006-03-21 | 2008-12-24 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of using same |
| EP2057188B1 (en) * | 2006-08-17 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Dpp-iv resistant gip hybrid polypeptides with selectable properties |
| EA020019B1 (ru) | 2008-08-07 | 2014-08-29 | Ипсен Фарма С.А.С. | Аналоги глюкозозависимого инсулинотропного полипептида |
| CN104031140B (zh) | 2008-08-07 | 2017-04-12 | 益普生制药股份有限公司 | 糖依赖性胰岛素释放肽的截短类似物 |
| KR101593155B1 (ko) | 2008-08-07 | 2016-02-12 | 입센 파마 에스.에이.에스. | 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체 |
| EA020091B1 (ru) | 2008-08-07 | 2014-08-29 | Ипсен Фарма С.А.С. | Аналоги глюкозозависимого инсулинотропного полипептида (gip), модифицированные по n-концу |
| WO2010016936A1 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide |
| CA2788304A1 (en) | 2010-01-27 | 2011-08-04 | Indiana University Research And Technology Corporation | Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity |
| US9023986B2 (en) | 2010-10-25 | 2015-05-05 | Hoffmann-La Roche Inc. | Glucose-dependent insulinotropic peptide analogs |
| US8975223B2 (en) * | 2010-12-22 | 2015-03-10 | Marcadia Biotech, Inc. | Methods for treating metabolic disorders and obesity with a peptide comprising the amino acid sequence of SEQ ID No. 146 |
| KR102002783B1 (ko) | 2011-06-10 | 2019-07-24 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | 포도당 의존성 인슐리노트로핀 폴리펩타이드 유사물질, 이의 약학적 조성물 및 응용 |
| EP2717925A1 (en) * | 2011-06-10 | 2014-04-16 | Universität Bern | Imaging and treatment of neuroendocrine tumors with glucose - dependent insulinotropic polypeptide or analogues or antagonists thereof |
| WO2014152460A2 (en) | 2013-03-15 | 2014-09-25 | Indiana University Research And Technology Corporation | Prodrugs with prolonged action |
| ES2685987T3 (es) * | 2014-09-05 | 2018-10-15 | University Of Copenhagen | Análogos de péptidos gip |
| DK3212218T3 (da) * | 2014-10-29 | 2021-08-30 | Zealand Pharma As | GIP-agonistforbindelser og fremgangsmåder |
| CN107921098A (zh) | 2015-06-17 | 2018-04-17 | 加州生物医学研究所 | 修饰的治疗剂及其组合物 |
| EP3526242A1 (en) * | 2016-10-12 | 2019-08-21 | University of Copenhagen | Peptide dual agonists of gipr and glp2r |
| WO2018124010A1 (ja) | 2016-12-26 | 2018-07-05 | 花王株式会社 | 認知機能改善剤 |
| US20190330332A1 (en) | 2016-12-26 | 2019-10-31 | Kao Corporation | Hypothermia Ameliorating Agent |
| CN110139672A (zh) | 2016-12-26 | 2019-08-16 | 花王株式会社 | 运动调节功能提高剂 |
| PL3630806T3 (pl) | 2017-05-31 | 2024-05-13 | The University Of Copenhagen | Analogi peptydów gip o długotrwałym działaniu |
-
2018
- 2018-05-31 PL PL18728872.5T patent/PL3630806T3/pl unknown
- 2018-05-31 US US16/617,698 patent/US11572399B2/en active Active
- 2018-05-31 WO PCT/EP2018/064355 patent/WO2018220123A1/en not_active Ceased
- 2018-05-31 ES ES18728872T patent/ES2972848T3/es active Active
- 2018-05-31 EP EP24150677.3A patent/EP4361173A3/en active Pending
- 2018-05-31 AU AU2018276434A patent/AU2018276434B2/en active Active
- 2018-05-31 BR BR112019025195A patent/BR112019025195A8/pt unknown
- 2018-05-31 JP JP2019565921A patent/JP2020521784A/ja active Pending
- 2018-05-31 EP EP18728872.5A patent/EP3630806B1/en active Active
- 2018-05-31 CN CN201880036341.0A patent/CN110691788B/zh active Active
- 2018-05-31 KR KR1020197034279A patent/KR102743887B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018276434A1 (en) | 2020-01-02 |
| WO2018220123A1 (en) | 2018-12-06 |
| CA3064510A1 (en) | 2018-12-06 |
| EP4361173A2 (en) | 2024-05-01 |
| EP3630806B1 (en) | 2024-01-10 |
| PL3630806T3 (pl) | 2024-05-13 |
| BR112019025195A8 (pt) | 2020-07-07 |
| CN110691788A (zh) | 2020-01-14 |
| CN110691788B (zh) | 2024-05-31 |
| EP4361173A3 (en) | 2024-07-03 |
| US20200087373A1 (en) | 2020-03-19 |
| US11572399B2 (en) | 2023-02-07 |
| KR20200014287A (ko) | 2020-02-10 |
| AU2018276434B2 (en) | 2021-12-16 |
| JP2020521784A (ja) | 2020-07-27 |
| EP3630806A1 (en) | 2020-04-08 |
| BR112019025195A2 (pt) | 2020-06-23 |
| KR102743887B1 (ko) | 2024-12-19 |
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