AU2018276434B2 - Long-acting GIP peptide analogues - Google Patents

Long-acting GIP peptide analogues Download PDF

Info

Publication number
AU2018276434B2
AU2018276434B2 AU2018276434A AU2018276434A AU2018276434B2 AU 2018276434 B2 AU2018276434 B2 AU 2018276434B2 AU 2018276434 A AU2018276434 A AU 2018276434A AU 2018276434 A AU2018276434 A AU 2018276434A AU 2018276434 B2 AU2018276434 B2 AU 2018276434B2
Authority
AU
Australia
Prior art keywords
seq
hgip
amino acid
gip
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018276434A
Other languages
English (en)
Other versions
AU2018276434A1 (en
Inventor
Maria Buur Nordskov Gabe
Lærke Smidt GASBJERG
Jens Juul Holst
Mette Marie Rosenkilde
Alexander Hovard SPARRE-ULRICH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Københavns Universitet
Original Assignee
Københavns Universitet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Københavns Universitet filed Critical Københavns Universitet
Publication of AU2018276434A1 publication Critical patent/AU2018276434A1/en
Application granted granted Critical
Publication of AU2018276434B2 publication Critical patent/AU2018276434B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
AU2018276434A 2017-05-31 2018-05-31 Long-acting GIP peptide analogues Active AU2018276434B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17173628.3 2017-05-31
EP17173628 2017-05-31
PCT/EP2018/064355 WO2018220123A1 (en) 2017-05-31 2018-05-31 Long-acting gip peptide analogues

Publications (2)

Publication Number Publication Date
AU2018276434A1 AU2018276434A1 (en) 2020-01-02
AU2018276434B2 true AU2018276434B2 (en) 2021-12-16

Family

ID=59021262

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018276434A Active AU2018276434B2 (en) 2017-05-31 2018-05-31 Long-acting GIP peptide analogues

Country Status (10)

Country Link
US (1) US11572399B2 (enExample)
EP (2) EP4361173A3 (enExample)
JP (1) JP2020521784A (enExample)
KR (1) KR102743887B1 (enExample)
CN (1) CN110691788B (enExample)
AU (1) AU2018276434B2 (enExample)
BR (1) BR112019025195A8 (enExample)
ES (1) ES2972848T3 (enExample)
PL (1) PL3630806T3 (enExample)
WO (1) WO2018220123A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016034186A1 (en) 2014-09-05 2016-03-10 University Of Copenhagen Gip peptide analogues
KR102743887B1 (ko) 2017-05-31 2024-12-19 유니버시티 오브 코펜하겐 장기-작용성 gip 펩타이드 유사체
MX2020011427A (es) 2018-05-04 2020-12-07 Novo Nordisk As Derivados del polipeptido insulinotropico dependiente de la glucosa (gip) y usos de estos.
WO2020115048A1 (en) * 2018-12-03 2020-06-11 Antag Therapeutics Aps Modified gip peptide analogues
MX2022006737A (es) * 2019-12-03 2022-06-14 Antag Therapeutics Aps Analogos peptidicos del peptido insulinotropico dependiente de glucosa (gip) optimizados.
WO2023139106A2 (en) 2022-01-18 2023-07-27 Novo Nordisk A/S Long-acting gipr antagonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088379A2 (en) * 2010-12-22 2012-06-28 Marcadia Biotech, Inc. Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869602A (en) 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
CA2264243C (en) 1996-08-30 2004-10-05 Novo Nordisk A/S Glp-1 derivatives
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
WO1998024464A1 (en) 1996-12-03 1998-06-11 Trustees Of Boston University Specific antagonists for glucose-dependent insulinotropic polypeptide (gip)
CZ297361B6 (cs) 1998-01-30 2006-11-15 Novo Nordisk A/S Injekcní stríkacka
WO1999043708A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
DE69918070T2 (de) 1998-03-13 2005-08-25 Novo Nordisk A/S Stabilisierte, wässrige Glukagonlösungen, enthaltend Detergenzien
WO2000020592A1 (en) 1998-10-07 2000-04-13 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
CN1495198A (zh) 1998-12-07 2004-05-12 �о���Ӧ�ÿ�ѧЭ��ɷ����޹�˾ 胰高血糖素样肽-1的类似物
US6921748B1 (en) 1999-03-29 2005-07-26 Uutech Limited Analogs of gastric inhibitory polypeptide and their use for treatment of diabetes
GB0404124D0 (en) * 2004-02-25 2004-03-31 Univ Ulster Antagonists of GIP
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
PT1355942E (pt) 2000-12-07 2008-11-21 Lilly Co Eli Proteínas de fusão de glp-1
US20030232761A1 (en) 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20050059605A1 (en) 2003-01-31 2005-03-17 Krishna Peri Chemically modified metabolites of regulatory peptides and methods of producing and using same
EA011653B1 (ru) 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Аналоги и гибридные полипептиды gip с избираемыми свойствами
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
US20090186817A1 (en) 2006-03-21 2009-07-23 Amylin Pharmaceuticals, Inc. Peptide-peptidase inhibitor conjugates and methods of using same
AU2007284365A1 (en) 2006-08-17 2008-02-21 Amylin Pharmaceuticals, Inc. DPP-IV resistant GIP hybrid polypeptides with selectable properties
PL2320923T3 (pl) 2008-08-07 2015-06-30 Ipsen Pharma Sas Skrócone analogi peptydu insulinotropowego zależnego od glukozy
JP2011530507A (ja) 2008-08-07 2011-12-22 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ グルコース依存性インスリン分泌刺激ポリペプチドアナログ
WO2010016936A1 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide
JP2011530508A (ja) 2008-08-07 2011-12-22 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ グルコース依存性インスリン分泌刺激ポリペプチドのアナログ
WO2010016944A2 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal
CN102834108A (zh) 2010-01-27 2012-12-19 印第安纳大学研究及科技有限公司 用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物
US9023986B2 (en) 2010-10-25 2015-05-05 Hoffmann-La Roche Inc. Glucose-dependent insulinotropic peptide analogs
JP5914641B2 (ja) * 2011-06-10 2016-05-11 ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッドBeijing Hanmi Pharmaceutical Co., Ltd. グルコース依存性インスリン分泌刺激ポリペプチドのアナログ、医薬組成物及びその使用
WO2012168464A1 (en) * 2011-06-10 2012-12-13 Universität Bern Imaging and treatment of neuroendocrine tumors with glucose - dependent insulinotropic polypeptide or analogues or antagonists thereof
JP2016521253A (ja) 2013-03-15 2016-07-21 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 持続性作用を有するプロドラッグ
WO2016034186A1 (en) * 2014-09-05 2016-03-10 University Of Copenhagen Gip peptide analogues
DK3212218T3 (da) 2014-10-29 2021-08-30 Zealand Pharma As GIP-agonistforbindelser og fremgangsmåder
US20190000928A1 (en) 2015-06-17 2019-01-03 The California Institute For Biomedical Research Modified therapeutic agents and compositions thereof
US10774127B2 (en) * 2016-10-12 2020-09-15 University Of Copenhagen Peptide dual agonists of GIPR and GLP2R
CN110087686A (zh) 2016-12-26 2019-08-02 花王株式会社 认知功能改善剂
EP3560514A4 (en) 2016-12-26 2020-12-23 Kao Corporation Hypothermic drugs
JP7165495B2 (ja) 2016-12-26 2022-11-04 花王株式会社 運動調節機能向上剤
KR102743887B1 (ko) 2017-05-31 2024-12-19 유니버시티 오브 코펜하겐 장기-작용성 gip 펩타이드 유사체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088379A2 (en) * 2010-12-22 2012-06-28 Marcadia Biotech, Inc. Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATHAK V ET AL, MOLECULAR AND CELLULAR ENDOCRINOLOGY, (2014-11-06), vol. 401, doi:10.1016/J.MCE.2014.10.025, ISSN 0303-7207, pages 120 - 129 *

Also Published As

Publication number Publication date
CA3064510A1 (en) 2018-12-06
KR20200014287A (ko) 2020-02-10
KR102743887B1 (ko) 2024-12-19
BR112019025195A8 (pt) 2020-07-07
PL3630806T3 (pl) 2024-05-13
BR112019025195A2 (pt) 2020-06-23
CN110691788B (zh) 2024-05-31
EP3630806B1 (en) 2024-01-10
US20200087373A1 (en) 2020-03-19
EP4361173A2 (en) 2024-05-01
EP4361173A3 (en) 2024-07-03
CN110691788A (zh) 2020-01-14
ES2972848T3 (es) 2024-06-17
EP3630806A1 (en) 2020-04-08
WO2018220123A1 (en) 2018-12-06
AU2018276434A1 (en) 2020-01-02
JP2020521784A (ja) 2020-07-27
US11572399B2 (en) 2023-02-07

Similar Documents

Publication Publication Date Title
US12187773B2 (en) Modified GIP peptide analogues
AU2018276434B2 (en) Long-acting GIP peptide analogues
JP6354017B2 (ja) グルカゴン受容体アゴニスト
US20210340211A1 (en) Gip peptide analogues
KR20110043686A (ko) 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드의 유사체
AU2020398675A1 (en) Optimized GIP peptide analogues
CA3064510C (en) Long-acting gip peptide analogues
RU2817673C2 (ru) Модифицированные аналоги GIP пептида
CN121449720A (en) Modified GIP peptide analogues
CN121449721A (en) Modified GIP peptide analogues

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)