CN110691788B - 长效gip肽类似物 - Google Patents

长效gip肽类似物 Download PDF

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Publication number
CN110691788B
CN110691788B CN201880036341.0A CN201880036341A CN110691788B CN 110691788 B CN110691788 B CN 110691788B CN 201880036341 A CN201880036341 A CN 201880036341A CN 110691788 B CN110691788 B CN 110691788B
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China
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seq
hgip
gip
amino acid
fatty acid
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Chinese (zh)
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CN110691788A (zh
Inventor
M·M·罗森基尔德
J·J·霍尔斯特
L·S·加斯伯格
A·H·斯巴尔-乌尔里希
M·B·N·加布
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Københavns Universitet
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Københavns Universitet
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
CN201880036341.0A 2017-05-31 2018-05-31 长效gip肽类似物 Active CN110691788B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17173628.3 2017-05-31
EP17173628 2017-05-31
PCT/EP2018/064355 WO2018220123A1 (en) 2017-05-31 2018-05-31 Long-acting gip peptide analogues

Publications (2)

Publication Number Publication Date
CN110691788A CN110691788A (zh) 2020-01-14
CN110691788B true CN110691788B (zh) 2024-05-31

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Family Applications (1)

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CN201880036341.0A Active CN110691788B (zh) 2017-05-31 2018-05-31 长效gip肽类似物

Country Status (11)

Country Link
US (1) US11572399B2 (enExample)
EP (2) EP3630806B1 (enExample)
JP (1) JP2020521784A (enExample)
KR (1) KR102743887B1 (enExample)
CN (1) CN110691788B (enExample)
AU (1) AU2018276434B2 (enExample)
BR (1) BR112019025195A8 (enExample)
CA (1) CA3064510A1 (enExample)
ES (1) ES2972848T3 (enExample)
PL (1) PL3630806T3 (enExample)
WO (1) WO2018220123A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10968266B2 (en) 2014-09-05 2021-04-06 University Of Copenhagen GIP peptide analogues
CN110691788B (zh) 2017-05-31 2024-05-31 哥本哈根大学 长效gip肽类似物
CN112074531B (zh) * 2018-05-04 2025-04-15 诺和诺德股份有限公司 Gip衍生物及其用途
KR20210102911A (ko) 2018-12-03 2021-08-20 안타그 테라퓨틱스 에이피에스 변형된 gip 펩티드 유사체
WO2023139106A2 (en) 2022-01-18 2023-07-27 Novo Nordisk A/S Long-acting gipr antagonists

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WO2012088379A2 (en) * 2010-12-22 2012-06-28 Marcadia Biotech, Inc. Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides
WO2016034186A1 (en) * 2014-09-05 2016-03-10 University Of Copenhagen Gip peptide analogues
WO2016066744A2 (en) * 2014-10-29 2016-05-06 Zealand Pharma A/S Gip agonist compounds and methods

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US6384016B1 (en) 1998-03-13 2002-05-07 Novo Nordisk A/S Stabilized aqueous peptide solutions
AU5518798A (en) 1996-12-03 1998-06-29 Trustees Of Boston University Specific antagonists for glucose-dependent insulinotropic polypeptide (gip)
UA56256C2 (uk) 1998-01-30 2003-05-15 Ново Нордіск А/С Шприц для ін'єкцій
WO1999043708A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
AU6294899A (en) 1998-10-07 2000-04-26 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
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PT1171465E (pt) 1999-03-29 2004-12-31 Uutech Ltd Analogos de petido inibidor gastrico e sua utilizacao para o tratamento de diabetes
GB0404124D0 (en) * 2004-02-25 2004-03-31 Univ Ulster Antagonists of GIP
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
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WO2006086769A2 (en) 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Inc. Gip analog and hybrid polypeptides with selectable properties
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
EP2004238A2 (en) 2006-03-21 2008-12-24 Amylin Pharmaceuticals, Inc. Peptide-peptidase inhibitor conjugates and methods of using same
CA2660835A1 (en) 2006-08-17 2008-02-21 Amylin Pharmaceuticals, Inc. Dpp-iv resistant gip hybrid polypeptides with selectable propperties
WO2010016936A1 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide
EP2318433A4 (en) 2008-08-07 2012-08-08 Ipsen Pharma Sas GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGUES (GIP) MODIFIED AT THE N-TERMINAL END
US9074014B2 (en) 2008-08-07 2015-07-07 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
MX2011001030A (es) 2008-08-07 2011-04-26 Ipsen Pharma Sas Analogos de polipeptidos insulinotropicos dependientes de glucosa.
EP2320923B1 (en) 2008-08-07 2014-12-24 Ipsen Pharma S.A.S. Truncated analogues of glucose-dependent insulinotropic polypeptide
EP2528618A4 (en) * 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
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EP2718317B1 (en) * 2011-06-10 2018-11-14 Beijing Hanmi Pharmaceutical Co., Ltd. Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
US20140377171A1 (en) * 2011-06-10 2014-12-25 Jean Claude Reubi Imaging and Treatment of Neuroendocrine Tumors with Glucose - Dependent Insulinotropic Polypeptide or Analogues or Antagonists Thereof
CN105324125A (zh) 2013-03-15 2016-02-10 印第安纳大学研究及科技有限公司 具有长效的前体药物
US20190000928A1 (en) 2015-06-17 2019-01-03 The California Institute For Biomedical Research Modified therapeutic agents and compositions thereof
EP3526242A1 (en) * 2016-10-12 2019-08-21 University of Copenhagen Peptide dual agonists of gipr and glp2r
CN110099694A (zh) 2016-12-26 2019-08-06 花王株式会社 低体温改善剂
JP7165496B2 (ja) 2016-12-26 2022-11-04 花王株式会社 認知機能改善剤
US11319369B2 (en) 2016-12-26 2022-05-03 Kao Corporation Motor control function improving agent
CN110691788B (zh) 2017-05-31 2024-05-31 哥本哈根大学 长效gip肽类似物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088379A2 (en) * 2010-12-22 2012-06-28 Marcadia Biotech, Inc. Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides
WO2016034186A1 (en) * 2014-09-05 2016-03-10 University Of Copenhagen Gip peptide analogues
WO2016066744A2 (en) * 2014-10-29 2016-05-06 Zealand Pharma A/S Gip agonist compounds and methods

Also Published As

Publication number Publication date
ES2972848T3 (es) 2024-06-17
CA3064510A1 (en) 2018-12-06
AU2018276434B2 (en) 2021-12-16
US20200087373A1 (en) 2020-03-19
PL3630806T3 (pl) 2024-05-13
JP2020521784A (ja) 2020-07-27
BR112019025195A8 (pt) 2020-07-07
BR112019025195A2 (pt) 2020-06-23
CN110691788A (zh) 2020-01-14
EP3630806B1 (en) 2024-01-10
EP3630806A1 (en) 2020-04-08
AU2018276434A1 (en) 2020-01-02
US11572399B2 (en) 2023-02-07
KR102743887B1 (ko) 2024-12-19
WO2018220123A1 (en) 2018-12-06
EP4361173A3 (en) 2024-07-03
EP4361173A2 (en) 2024-05-01
KR20200014287A (ko) 2020-02-10

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