ES2927271T3 - Inhibidor de esterasa C1 humana recombinante y usos del mismo - Google Patents
Inhibidor de esterasa C1 humana recombinante y usos del mismo Download PDFInfo
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- ES2927271T3 ES2927271T3 ES16810158T ES16810158T ES2927271T3 ES 2927271 T3 ES2927271 T3 ES 2927271T3 ES 16810158 T ES16810158 T ES 16810158T ES 16810158 T ES16810158 T ES 16810158T ES 2927271 T3 ES2927271 T3 ES 2927271T3
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Classifications
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- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
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- Epidemiology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257711P | 2015-11-19 | 2015-11-19 | |
| PCT/US2016/062906 WO2017087882A1 (en) | 2015-11-19 | 2016-11-18 | Recombinant human c1 esterase inhibitor and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2927271T3 true ES2927271T3 (es) | 2022-11-03 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16810158T Active ES2927271T3 (es) | 2015-11-19 | 2016-11-18 | Inhibidor de esterasa C1 humana recombinante y usos del mismo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12209116B2 (https=) |
| EP (1) | EP3377093B1 (https=) |
| JP (3) | JP7189767B2 (https=) |
| CN (1) | CN108463243B (https=) |
| BR (1) | BR112018010160A8 (https=) |
| CA (1) | CA3005906A1 (https=) |
| ES (1) | ES2927271T3 (https=) |
| MA (1) | MA43270A (https=) |
| WO (1) | WO2017087882A1 (https=) |
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| WO2019166572A1 (en) * | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| JP7470119B2 (ja) | 2018-08-24 | 2024-04-17 | シーエスエル ベーリング ジーン セラピー インコーポレイテッド | 無血清培地におけるベクター産生 |
| US20210380636A1 (en) * | 2018-10-17 | 2021-12-09 | Csl Behring Gmbh | Process for purifying c1-inh |
| EP3994165A1 (en) * | 2019-07-04 | 2022-05-11 | CSL Behring GmbH | Process for purifying c1-inh |
| SE546553C2 (en) * | 2019-10-08 | 2024-11-26 | Hubert Schwarz | A method to feed component in perfusion culture |
| WO2021081280A1 (en) * | 2019-10-23 | 2021-04-29 | Shire Human Genetic Therapies, Inc. | Adeno-associated virus vectors based gene therapy for hereditary angioedema |
| CN111087475B (zh) * | 2019-12-25 | 2022-07-08 | 东莞市东阳光生物药研发有限公司 | Fgf21融合蛋白及抑制其降解的方法 |
| RU2769201C2 (ru) * | 2020-06-23 | 2022-03-29 | Акционерное общество "ГЕНЕРИУМ" | Способ получения высокоочищенного рекомбинантного ингибитора с1-эстеразы человека для медицинского применения |
| US20230323422A1 (en) * | 2020-08-14 | 2023-10-12 | Bristol-Myers Squibb Company | Method of making protein |
| BE1029146B1 (fr) * | 2021-02-26 | 2022-09-26 | Xpress Biologics | Procede de purification d'une proteine d'interet |
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| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US5149636A (en) | 1982-03-15 | 1992-09-22 | Trustees Of Columbia University In The City Of New York | Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| US5622930A (en) * | 1989-10-27 | 1997-04-22 | Clb | C1 inhibitor muteins and uses thereof |
| US5096816A (en) | 1990-06-05 | 1992-03-17 | Cetus Corporation | In vitro management of ammonia's effect on glycosylation of cell products through pH control |
| FR2672895B1 (fr) | 1991-02-15 | 1995-05-12 | Transgene Sa | Procede de purification d'une proteine fortement glycosylee. |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US6528286B1 (en) | 1998-05-29 | 2003-03-04 | Genentech, Inc. | Mammalian cell culture process for producing glycoproteins |
| JP3543106B2 (ja) * | 1999-07-21 | 2004-07-14 | 大阪大学長 | 膜結合型ｃ１インアクチベーター |
| CA2398707C (en) | 2000-01-31 | 2010-10-26 | Pharming Intellectual Property B.V. | C1 inhibitor produced in the milk of transgenic mammals |
| EP1543106B1 (en) | 2002-07-15 | 2007-04-11 | Immunex Corporation | Methods and media for controlling sialylation of proteins produced by mammalian cells |
| WO2004034971A2 (en) * | 2002-09-25 | 2004-04-29 | The Center For Blood Research, Inc. | Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof |
| US8524477B2 (en) | 2002-10-29 | 2013-09-03 | Crucell Holland B.V. | Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby |
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| PL2380587T3 (pl) * | 2005-12-21 | 2018-03-30 | Pharming Intellectual Property B.V. | Zastosowanie inhibitora C1 do zapobiegania uszkodzeniu niedokrwiennoreperfuzyjnemu |
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| EP2930245B1 (en) | 2007-10-12 | 2017-11-22 | Sigma-Aldrich Co. LLC | Cell line and methods for improved glycoprotein sialylation |
| RU2495131C2 (ru) | 2008-02-19 | 2013-10-10 | Байокон Лимитид | Способ получения рекомбинантного инсулина гларгина |
| WO2009143493A2 (en) * | 2008-05-22 | 2009-11-26 | Attagene Inc. | MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF |
| EP2166085A1 (en) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalent modified cells |
| CN102317309A (zh) | 2009-02-26 | 2012-01-11 | 巴特勒能源同盟有限公司 | 通过不同的翻译后修饰改变和调节蛋白质活性 |
| US20130085111A1 (en) * | 2010-03-18 | 2013-04-04 | Thrombolytic Science, Llc | Production of human c1 inhibitor in human cells |
| JP5907540B2 (ja) | 2011-02-10 | 2016-04-26 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 綿を含む固定相を用いるクロマトグラフィーによりグリカン及び／又は複合糖質を精製するための方法 |
| DK2729482T3 (en) | 2011-07-08 | 2018-05-07 | Merck Sharp & Dohme | PROCEDURE FOR CLEANING FC-FUSION PROTEIN |
| WO2013093760A2 (en) | 2011-12-19 | 2013-06-27 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| JP6127063B2 (ja) | 2011-12-22 | 2017-05-10 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 中枢神経系の続発性浮腫の治療のためのｃ１インヒビターの使用 |
| CA2867593A1 (en) * | 2012-03-16 | 2013-09-19 | Belrose Pharma, Inc. | Polymeric conjugates of c-1 inhibitors |
| CN105188750A (zh) | 2013-03-08 | 2015-12-23 | 德国杰特贝林生物制品有限公司 | 治疗和预防远端缺血-再灌注损伤 |
| RS58351B1 (sr) | 2013-03-15 | 2019-03-29 | Shire Viropharma Inc | C1-inh kompozicije i postupci za prevenciju i lečenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze |
| EP3110508A4 (en) * | 2014-02-28 | 2017-11-08 | Santarus Inc. | Treatment of hereditary angioedema with c1 inhibitor |
| ES2736127T3 (es) | 2014-03-20 | 2019-12-26 | Bristol Myers Squibb Co | Dominios de tipo III de fibronectina de unión a seroalbúmina |
| US20160130324A1 (en) | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| WO2016081889A1 (en) | 2014-11-21 | 2016-05-26 | Kurt Baekgaard Osther | Recombinant c1 esterase inhibitor and use thereof |
| EP3042952A1 (en) | 2015-01-07 | 2016-07-13 | CEVEC Pharmaceuticals GmbH | O-glycan sialylated recombinant glycoproteins and cell lines for producing the same |
-
2016
- 2016-11-18 CN CN201680078763.5A patent/CN108463243B/zh active Active
- 2016-11-18 MA MA043270A patent/MA43270A/fr unknown
- 2016-11-18 JP JP2018526218A patent/JP7189767B2/ja active Active
- 2016-11-18 EP EP16810158.2A patent/EP3377093B1/en active Active
- 2016-11-18 US US15/777,547 patent/US12209116B2/en active Active
- 2016-11-18 ES ES16810158T patent/ES2927271T3/es active Active
- 2016-11-18 WO PCT/US2016/062906 patent/WO2017087882A1/en not_active Ceased
- 2016-11-18 CA CA3005906A patent/CA3005906A1/en active Pending
- 2016-11-18 BR BR112018010160A patent/BR112018010160A8/pt not_active Application Discontinuation
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2021
- 2021-06-25 JP JP2021105576A patent/JP2021155438A/ja active Pending
-
2023
- 2023-04-21 JP JP2023070030A patent/JP7562747B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US12209116B2 (en) | 2025-01-28 |
| CN108463243B (zh) | 2022-06-14 |
| JP2018538270A (ja) | 2018-12-27 |
| EP3377093B1 (en) | 2022-07-13 |
| BR112018010160A8 (pt) | 2019-02-26 |
| CN108463243A (zh) | 2018-08-28 |
| BR112018010160A2 (pt) | 2018-11-21 |
| JP2023083499A (ja) | 2023-06-15 |
| EP3377093A1 (en) | 2018-09-26 |
| CA3005906A1 (en) | 2017-05-26 |
| MA43270A (fr) | 2021-06-02 |
| JP7562747B2 (ja) | 2024-10-07 |
| JP2021155438A (ja) | 2021-10-07 |
| JP7189767B2 (ja) | 2022-12-14 |
| US20180334493A1 (en) | 2018-11-22 |
| WO2017087882A1 (en) | 2017-05-26 |
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