ES2902879T3 - Método de cuantificación de células inmunitarias en tejidos tumorales y sus aplicaciones - Google Patents
Método de cuantificación de células inmunitarias en tejidos tumorales y sus aplicaciones Download PDFInfo
- Publication number
- ES2902879T3 ES2902879T3 ES13731071T ES13731071T ES2902879T3 ES 2902879 T3 ES2902879 T3 ES 2902879T3 ES 13731071 T ES13731071 T ES 13731071T ES 13731071 T ES13731071 T ES 13731071T ES 2902879 T3 ES2902879 T3 ES 2902879T3
- Authority
- ES
- Spain
- Prior art keywords
- tumor
- cells
- stained
- density
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2902879T3 true ES2902879T3 (es) | 2022-03-30 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13731071T Active ES2902879T3 (es) | 2012-06-14 | 2013-06-14 | Método de cuantificación de células inmunitarias en tejidos tumorales y sus aplicaciones |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10317408B2 (https=) |
| EP (1) | EP2861986B1 (https=) |
| JP (1) | JP6449765B2 (https=) |
| KR (1) | KR102179848B1 (https=) |
| CN (1) | CN104541167B (https=) |
| AU (1) | AU2013276470B2 (https=) |
| BR (1) | BR112014031143B8 (https=) |
| CA (1) | CA2873278C (https=) |
| DE (1) | DE13731071T1 (https=) |
| ES (1) | ES2902879T3 (https=) |
| IL (1) | IL235738B (https=) |
| SG (1) | SG11201408107RA (https=) |
| WO (1) | WO2013186374A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2940115C (en) | 2014-02-24 | 2023-03-14 | Ventana Medical Systems, Inc. | Methods, kits, and systems for scoring the immune response to cancer by simultaneous detection of cd3, cd8, cd20 and foxp3 |
| WO2016034655A2 (en) * | 2014-09-03 | 2016-03-10 | Ventana Medical Systems, Inc. | Systems and methods for generating fields of view |
| US11275080B2 (en) | 2014-11-05 | 2022-03-15 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block PD1/PDL1 axis |
| CA2973878A1 (en) | 2015-01-22 | 2016-07-28 | University Of Massachusetts | Cancer immunotherapy |
| US10705088B2 (en) * | 2015-10-23 | 2020-07-07 | Novartis Ag | Method of scoring a sample comprising tumor tissue |
| EP3455631B1 (en) * | 2016-05-09 | 2020-06-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for classifying patients with a solid cancer |
| EP3889893B1 (en) * | 2016-05-18 | 2022-03-30 | F. Hoffmann-La Roche AG | Tumor proximity measure |
| WO2018027223A1 (en) * | 2016-08-05 | 2018-02-08 | Duke University | Camkk2 inhibitor compositions and methods of using the same |
| EP3532984B1 (en) * | 2016-10-27 | 2024-05-08 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| US11459568B2 (en) | 2016-10-31 | 2022-10-04 | University Of Massachusetts | Targeting microRNA-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| EP3659110A1 (en) * | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| ES2965647T3 (es) | 2018-01-31 | 2024-04-16 | Ventana Med Syst Inc | Procedimientos y sistemas para la evaluación de infiltrado de células inmunitarias en cáncer colorrectal en estadio III |
| WO2020161125A1 (en) * | 2019-02-05 | 2020-08-13 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| SG11202112712RA (en) | 2019-06-03 | 2021-12-30 | Inst Nat Sante Rech Med | Methods for modulating a treatment regimen |
| WO2021092071A1 (en) | 2019-11-07 | 2021-05-14 | Oncxerna Therapeutics, Inc. | Classification of tumor microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| EP4172628A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| US20230235408A1 (en) | 2020-06-30 | 2023-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| JP2024530213A (ja) | 2021-08-10 | 2024-08-16 | ルニット・インコーポレイテッド | 病理スライド画像に関する情報を出力する方法及び装置 |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| AU2024239150A1 (en) | 2023-03-21 | 2025-10-02 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69627183T2 (de) * | 1995-11-30 | 2004-01-29 | Chromavision Med Sys Inc | Verfahren zur automatischen bildanalyse biologischer proben |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| ES2593930T3 (es) * | 2005-12-19 | 2016-12-14 | Ventana Medical Systems, Inc. | Impresión automatizada de etiquetas para portaobjetos de especímenes de tejido |
| JP5551702B2 (ja) * | 2008-09-16 | 2014-07-16 | ヒストロックス，インコーポレイテッド． | バイオマーカー発現の再現性のある定量 |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en not_active Ceased
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt not_active IP Right Cessation
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015525349A (ja) | 2015-09-03 |
| JP6449765B2 (ja) | 2019-01-09 |
| KR20150023760A (ko) | 2015-03-05 |
| BR112014031143A2 (pt) | 2017-08-08 |
| US20150153349A1 (en) | 2015-06-04 |
| IL235738A0 (en) | 2015-01-29 |
| US10317408B2 (en) | 2019-06-11 |
| WO2013186374A1 (en) | 2013-12-19 |
| AU2013276470B2 (en) | 2018-06-07 |
| IL235738B (en) | 2019-02-28 |
| AU2013276470A1 (en) | 2014-11-27 |
| BR112014031143B1 (pt) | 2022-03-03 |
| BR112014031143B8 (pt) | 2022-11-22 |
| CN104541167B (zh) | 2018-05-01 |
| CN104541167A (zh) | 2015-04-22 |
| EP2861986B1 (en) | 2021-11-10 |
| EP2861986A1 (en) | 2015-04-22 |
| CA2873278A1 (en) | 2013-12-19 |
| DE13731071T1 (de) | 2016-08-18 |
| SG11201408107RA (en) | 2015-01-29 |
| KR102179848B1 (ko) | 2020-11-17 |
| CA2873278C (en) | 2021-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2902879T3 (es) | Método de cuantificación de células inmunitarias en tejidos tumorales y sus aplicaciones | |
| JP6405319B2 (ja) | 乳癌予知のための画像分析 | |
| CA2604317C (en) | Methods and system for validating sample images for quantitative immunoassays | |
| Braun et al. | Quantification of protein expression in cells and cellular subcompartments on immunohistochemical sections using a computer supported image analysis system | |
| ES2542106T3 (es) | Método para preparar videomicroscopía cuantitativa y sistema asociado | |
| JP5866362B2 (ja) | 画像解析による固形腫瘍進行の予後検査 | |
| EP3117259B1 (en) | Assessment of staining quality | |
| US20240310379A1 (en) | A method for measuring a prognostic marker in prostate cancer or in breast cancer | |
| KR20150023808A (ko) | 조직 절편 내 단일 세포에서의 마커 정량 | |
| Jing et al. | Validity and reliability of Ki-67 assessment in oestrogen receptor positive breast cancer | |
| Jiang et al. | Comparative study of different software in Ki67 assessment of breast cancer | |
| Burchhardt | Image analysis of immunohistochemistry-based biomarkers in breast cancer | |
| Pinder et al. | HER2 testing in the UK: further update to |