BR112014031143B8 - Método para quantificar células imunes em tecidos tumorais e suas aplicações - Google Patents
Método para quantificar células imunes em tecidos tumorais e suas aplicaçõesInfo
- Publication number
- BR112014031143B8 BR112014031143B8 BR112014031143A BR112014031143A BR112014031143B8 BR 112014031143 B8 BR112014031143 B8 BR 112014031143B8 BR 112014031143 A BR112014031143 A BR 112014031143A BR 112014031143 A BR112014031143 A BR 112014031143A BR 112014031143 B8 BR112014031143 B8 BR 112014031143B8
- Authority
- BR
- Brazil
- Prior art keywords
- immune cells
- tumor
- tumor tissues
- applications
- analyzed
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001446 | 2012-06-14 | ||
| IBPCT/IB2012/001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014031143A2 BR112014031143A2 (pt) | 2017-08-08 |
| BR112014031143B1 BR112014031143B1 (pt) | 2022-03-03 |
| BR112014031143B8 true BR112014031143B8 (pt) | 2022-11-22 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014031143A BR112014031143B8 (pt) | 2012-06-14 | 2013-06-14 | Método para quantificar células imunes em tecidos tumorais e suas aplicações |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10317408B2 (https=) |
| EP (1) | EP2861986B1 (https=) |
| JP (1) | JP6449765B2 (https=) |
| KR (1) | KR102179848B1 (https=) |
| CN (1) | CN104541167B (https=) |
| AU (1) | AU2013276470B2 (https=) |
| BR (1) | BR112014031143B8 (https=) |
| CA (1) | CA2873278C (https=) |
| DE (1) | DE13731071T1 (https=) |
| ES (1) | ES2902879T3 (https=) |
| IL (1) | IL235738B (https=) |
| SG (1) | SG11201408107RA (https=) |
| WO (1) | WO2013186374A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6605506B2 (ja) | 2014-02-24 | 2019-11-13 | ヴェンタナ メディカル システムズ， インク． | ＣＤ３、ＣＤ８、ＣＤ２０及びＦｏｘＰ３の同時検出によりがんに対する免疫応答をスコア化するための方法、キット、及びシステム |
| EP3195191B1 (en) * | 2014-09-03 | 2020-10-21 | Ventana Medical Systems, Inc. | Systems and methods for calculating immune scores |
| WO2016073760A1 (en) * | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block pd1/pdl1 axis |
| CA2973878A1 (en) | 2015-01-22 | 2016-07-28 | University Of Massachusetts | Cancer immunotherapy |
| US10705088B2 (en) * | 2015-10-23 | 2020-07-07 | Novartis Ag | Method of scoring a sample comprising tumor tissue |
| US20190309369A1 (en) * | 2016-05-09 | 2019-10-10 | Inserm (Institute National De La Sante Et De La Recherche Medicale) | Methods for classifying patients with a solid cancer |
| EP3459046B1 (en) * | 2016-05-18 | 2021-06-16 | F. Hoffmann-La Roche AG | Tumor proximity measure |
| US12158399B2 (en) * | 2016-08-05 | 2024-12-03 | Duke University | CaMKK2 inhibitor compositions and methods of using the same |
| US11048911B2 (en) * | 2016-10-27 | 2021-06-29 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| CA3037046A1 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| EP3659110A1 (en) * | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| DK3746790T3 (da) | 2018-01-31 | 2023-12-11 | Ventana Med Syst Inc | Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer |
| EP3921648A1 (en) * | 2019-02-05 | 2021-12-15 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| CN114072676B (zh) | 2019-06-03 | 2024-07-12 | 法国国家卫生及研究医学协会 | 调节治疗方案的方法 |
| CA3151629A1 (en) | 2019-11-07 | 2021-05-14 | Laura E. BENJAMIN | Classification of tumor microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| JP7741831B2 (ja) * | 2020-06-30 | 2025-09-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法 |
| CN115997123A (zh) | 2020-06-30 | 2023-04-21 | 国家医疗保健研究所 | 用于预测实体癌患者在术前辅助治疗后复发和/或死亡风险的方法 |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| WO2023018085A1 (ko) * | 2021-08-10 | 2023-02-16 | 주식회사 루닛 | 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치 |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| JP2026510999A (ja) | 2023-03-21 | 2026-04-10 | バイオグラフ ５５，インク． | Ｃｄ１９／ｃｄ３８多重特異性抗体 |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2236268A1 (en) * | 1995-11-30 | 1997-06-05 | Chromavision Medical Systems, Inc. | Method and apparatus for automated image analysis of biological specimens |
| EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| AU2006333078B2 (en) * | 2005-12-19 | 2012-03-01 | Ventana Medical Systems, Inc. | Automated lean methods in anatomical pathology |
| WO2010033508A1 (en) * | 2008-09-16 | 2010-03-25 | Historx, Inc. | Reproducible quantification of biomarker expression |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt not_active IP Right Cessation
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en not_active Ceased
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN104541167A (zh) | 2015-04-22 |
| BR112014031143A2 (pt) | 2017-08-08 |
| IL235738A0 (en) | 2015-01-29 |
| BR112014031143B1 (pt) | 2022-03-03 |
| IL235738B (en) | 2019-02-28 |
| EP2861986B1 (en) | 2021-11-10 |
| ES2902879T3 (es) | 2022-03-30 |
| WO2013186374A1 (en) | 2013-12-19 |
| JP2015525349A (ja) | 2015-09-03 |
| DE13731071T1 (de) | 2016-08-18 |
| CN104541167B (zh) | 2018-05-01 |
| AU2013276470A1 (en) | 2014-11-27 |
| JP6449765B2 (ja) | 2019-01-09 |
| KR20150023760A (ko) | 2015-03-05 |
| US10317408B2 (en) | 2019-06-11 |
| SG11201408107RA (en) | 2015-01-29 |
| AU2013276470B2 (en) | 2018-06-07 |
| KR102179848B1 (ko) | 2020-11-17 |
| US20150153349A1 (en) | 2015-06-04 |
| CA2873278C (en) | 2021-10-26 |
| CA2873278A1 (en) | 2013-12-19 |
| EP2861986A1 (en) | 2015-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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| B25A | Requested transfer of rights approved |
Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) ; ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) ; UNIVERSITE DE PARIS (FR) |
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| B25D | Requested change of name of applicant approved |
Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) ; ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) ; UNIVERSITE PARIS CITE (FR) |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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