ES2896502T3 - Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio - Google Patents

Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio Download PDF

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Publication number
ES2896502T3
ES2896502T3 ES18716062T ES18716062T ES2896502T3 ES 2896502 T3 ES2896502 T3 ES 2896502T3 ES 18716062 T ES18716062 T ES 18716062T ES 18716062 T ES18716062 T ES 18716062T ES 2896502 T3 ES2896502 T3 ES 2896502T3
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compound
cancer
disease
forms
crystalline form
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English (en)
Spanish (es)
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Jack Lin
Marika Nespi
Jason Walters
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Plexxikon Inc
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Plexxikon Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES18716062T 2017-03-20 2018-03-19 Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio Active ES2896502T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762473903P 2017-03-20 2017-03-20
PCT/US2018/023127 WO2018175311A1 (en) 2017-03-20 2018-03-19 Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain

Publications (1)

Publication Number Publication Date
ES2896502T3 true ES2896502T3 (es) 2022-02-24

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ES18716062T Active ES2896502T3 (es) 2017-03-20 2018-03-19 Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio

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US (1) US10577366B2 (US07585860-20090908-C00112.png)
EP (1) EP3601281B1 (US07585860-20090908-C00112.png)
JP (1) JP2020511467A (US07585860-20090908-C00112.png)
AU (1) AU2018237047A1 (US07585860-20090908-C00112.png)
CA (1) CA3056777A1 (US07585860-20090908-C00112.png)
ES (1) ES2896502T3 (US07585860-20090908-C00112.png)
WO (1) WO2018175311A1 (US07585860-20090908-C00112.png)

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Also Published As

Publication number Publication date
US10577366B2 (en) 2020-03-03
US20180265508A1 (en) 2018-09-20
CA3056777A1 (en) 2018-09-27
AU2018237047A1 (en) 2019-10-17
WO2018175311A1 (en) 2018-09-27
EP3601281B1 (en) 2021-09-29
EP3601281A1 (en) 2020-02-05
AU2018237047A2 (en) 2019-10-31
JP2020511467A (ja) 2020-04-16

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