ES2895965T3 - Moduladores del receptor de GABA(A) y métodos para controlar la hiperreactividad de las vías respiratorias y la inflamación en el asma - Google Patents
Moduladores del receptor de GABA(A) y métodos para controlar la hiperreactividad de las vías respiratorias y la inflamación en el asma Download PDFInfo
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- ES2895965T3 ES2895965T3 ES17758373T ES17758373T ES2895965T3 ES 2895965 T3 ES2895965 T3 ES 2895965T3 ES 17758373 T ES17758373 T ES 17758373T ES 17758373 T ES17758373 T ES 17758373T ES 2895965 T3 ES2895965 T3 ES 2895965T3
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375694P | 2016-08-16 | 2016-08-16 | |
| US201662427771P | 2016-11-29 | 2016-11-29 | |
| PCT/US2017/047185 WO2018035246A1 (en) | 2016-08-16 | 2017-08-16 | Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2895965T3 true ES2895965T3 (es) | 2022-02-23 |
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| ES17758373T Active ES2895965T3 (es) | 2016-08-16 | 2017-08-16 | Moduladores del receptor de GABA(A) y métodos para controlar la hiperreactividad de las vías respiratorias y la inflamación en el asma |
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| AU (1) | AU2017313753B2 (enExample) |
| CA (1) | CA3033964A1 (enExample) |
| ES (1) | ES2895965T3 (enExample) |
| WO (1) | WO2018035246A1 (enExample) |
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| CN115380034A (zh) * | 2020-03-31 | 2022-11-22 | 豪夫迈·罗氏有限公司 | 作为GABA Aγ1 PAM的苯并二氮杂䓬衍生物 |
| EP3901155A1 (en) * | 2020-04-20 | 2021-10-27 | F. Hoffmann-La Roche AG | New benzodiazepine derivatives as gaba a gamma1 pam |
| WO2023052312A1 (en) | 2021-09-29 | 2023-04-06 | F. Hoffmann-La Roche Ag | New benzodiazepine derivatives as gaba a gamma1 pam |
| WO2023057415A1 (en) | 2021-10-06 | 2023-04-13 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4125726A (en) | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4401597A (en) | 1978-05-15 | 1983-08-30 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4238610A (en) | 1979-12-20 | 1980-12-09 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| ZA845757B (en) | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| US5317018A (en) | 1992-06-09 | 1994-05-31 | Armin Walser | Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy |
| TW349100B (en) | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
| CA2184802C (en) | 1995-10-10 | 2007-07-31 | Karl-Heinz Bender | Process for manufacture of imidazo benzodiazepine derivatives |
| GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| US20010014738A1 (en) | 1999-06-30 | 2001-08-16 | Madhup K. Dhaon | Process for the preparation of imidazodiazepine intermediates |
| US6512114B1 (en) | 1999-06-30 | 2003-01-28 | Abbott Laboratories | Process for the preparation of Midazolam |
| US6262260B1 (en) | 2000-03-23 | 2001-07-17 | Abbott Laboratories | Process for the preparation of midazolam |
| KR100865410B1 (ko) | 2002-03-28 | 2008-10-24 | 위시스 테크놀로지 파운데이션, 인크. | 진정 및 운동실조 효과가 감소된 항불안제 |
| US8835424B2 (en) | 2002-03-28 | 2014-09-16 | Wisconsin Alumni Research Foundation | Selective agents for pain suppression |
| CN1968928A (zh) | 2004-06-09 | 2007-05-23 | 阿文尼尔药品公司 | 用于治疗高脂血症及相关疾病的杂环衍生物 |
| EP1761508A1 (en) * | 2004-06-30 | 2007-03-14 | Wisys Technology Foundation, Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| EP1888594A2 (en) | 2005-05-16 | 2008-02-20 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
| US8119629B2 (en) | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| US20100261711A1 (en) | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
| IT1399764B1 (it) | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| US9006233B2 (en) * | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| RU2017140639A (ru) | 2011-05-23 | 2019-02-12 | Элан Фармасьютикалз, Инк. | Ингибиторы активности киназы lrrk2 |
| EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| CN103204838B (zh) | 2012-01-13 | 2017-06-09 | 北京盛诺基医药科技有限公司 | 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用 |
| CN103319486B (zh) | 2012-03-22 | 2017-10-10 | 徐州市心血管病研究所 | 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法 |
| CA2885148A1 (en) | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| SI3439665T1 (sl) | 2016-03-18 | 2023-05-31 | Uwm Research Foundation, Inc. | Zdravljenje kognitivnih simptomov in simptomov razpoloženja pri nevrodegenerativnih in nevropsihiatričnih motnjah z agonisti receptorja GABAA, ki vsebujejo ALFA5 |
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2017
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- 2017-08-16 EP EP17758373.9A patent/EP3500573B1/en active Active
- 2017-08-16 ES ES17758373T patent/ES2895965T3/es active Active
- 2017-08-16 US US16/325,080 patent/US11447495B2/en active Active
- 2017-08-16 CN CN201780063337.9A patent/CN109790170B/zh active Active
- 2017-08-16 CA CA3033964A patent/CA3033964A1/en active Pending
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| US20230103216A1 (en) | 2023-03-30 |
| EP3500573A1 (en) | 2019-06-26 |
| AU2017313753B2 (en) | 2022-01-27 |
| AU2017313753A1 (en) | 2019-03-07 |
| US20210284649A1 (en) | 2021-09-16 |
| CN109790170B (zh) | 2022-08-02 |
| US11447495B2 (en) | 2022-09-20 |
| WO2018035246A1 (en) | 2018-02-22 |
| CN109790170A (zh) | 2019-05-21 |
| JP7013446B2 (ja) | 2022-02-15 |
| CA3033964A1 (en) | 2018-02-22 |
| BR112019003065A2 (pt) | 2019-05-21 |
| JP2019528267A (ja) | 2019-10-10 |
| EP3500573B1 (en) | 2021-10-06 |
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