CN109790170B - Gaba(a)受体调节剂和控制哮喘中气道高反应性和炎症的方法 - Google Patents

Gaba(a)受体调节剂和控制哮喘中气道高反应性和炎症的方法 Download PDF

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CN109790170B
CN109790170B CN201780063337.9A CN201780063337A CN109790170B CN 109790170 B CN109790170 B CN 109790170B CN 201780063337 A CN201780063337 A CN 201780063337A CN 109790170 B CN109790170 B CN 109790170B
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compound
compounds
gaba
mice
pharmaceutically acceptable
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Chinese (zh)
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CN109790170A (zh
Inventor
A.E.阿诺
D.C.斯塔福德
J.M.库克
C.W.埃马拉
G.福尔扩
R.贾罕
R.科达利
李官官
M.R.斯蒂芬
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Columbia University in the City of New York
UWM Research Foundation Inc
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Columbia University in the City of New York
UWM Research Foundation Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780063337.9A 2016-08-16 2017-08-16 Gaba(a)受体调节剂和控制哮喘中气道高反应性和炎症的方法 Active CN109790170B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662375694P 2016-08-16 2016-08-16
US62/375694 2016-08-16
US201662427771P 2016-11-29 2016-11-29
US62/427771 2016-11-29
PCT/US2017/047185 WO2018035246A1 (en) 2016-08-16 2017-08-16 Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma

Publications (2)

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CN109790170A CN109790170A (zh) 2019-05-21
CN109790170B true CN109790170B (zh) 2022-08-02

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US (2) US11447495B2 (enExample)
EP (1) EP3500573B1 (enExample)
JP (1) JP7013446B2 (enExample)
CN (1) CN109790170B (enExample)
AU (1) AU2017313753B2 (enExample)
CA (1) CA3033964A1 (enExample)
ES (1) ES2895965T3 (enExample)
WO (1) WO2018035246A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CA3167543A1 (en) * 2020-03-31 2021-10-07 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as gaba a gamma1 pams
EP3901155A1 (en) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG New benzodiazepine derivatives as gaba a gamma1 pam
CN118019742A (zh) 2021-09-29 2024-05-10 豪夫迈·罗氏有限公司 作为GABA A γ1 PAM的新颖苯并二氮杂䓬衍生物
KR20240073892A (ko) 2021-10-06 2024-05-27 에프. 호프만-라 로슈 아게 Gaba a gamma1 수용체의 양성 알로스테릭 조절인자로서의 벤조디아제핀 유도체

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WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma

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ZA845757B (en) 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
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TW349100B (en) 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
CA2184802C (en) 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
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AU2005260650A1 (en) * 2004-06-30 2006-01-12 Wisys Technology Foundation, Inc. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
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WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma

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EP3500573A1 (en) 2019-06-26
JP2019528267A (ja) 2019-10-10
US12054491B2 (en) 2024-08-06
WO2018035246A1 (en) 2018-02-22
US20230103216A1 (en) 2023-03-30
CN109790170A (zh) 2019-05-21
AU2017313753A1 (en) 2019-03-07
CA3033964A1 (en) 2018-02-22
ES2895965T3 (es) 2022-02-23
US11447495B2 (en) 2022-09-20
AU2017313753B2 (en) 2022-01-27
BR112019003065A2 (pt) 2019-05-21
US20210284649A1 (en) 2021-09-16
JP7013446B2 (ja) 2022-02-15
EP3500573B1 (en) 2021-10-06

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