ES2887201T3 - Variantes de empalme asociadas con mutantes neomórficos de SF3B1 - Google Patents

Variantes de empalme asociadas con mutantes neomórficos de SF3B1 Download PDF

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Publication number
ES2887201T3
ES2887201T3 ES16766420T ES16766420T ES2887201T3 ES 2887201 T3 ES2887201 T3 ES 2887201T3 ES 16766420 T ES16766420 T ES 16766420T ES 16766420 T ES16766420 T ES 16766420T ES 2887201 T3 ES2887201 T3 ES 2887201T3
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sf3b1
seq
cell
cancer
neomorphic
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Spanish (es)
Inventor
Lihua Yu
Kian Lim
Jacob Feala
Silvia Buonamici
Yoshiharu Mizui
Peter Smith
Ping Zhu
Eunice Park
Michael Seiler
Marco Fekkes
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Eisai R&D Management Co Ltd
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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ES16766420T 2015-09-01 2016-08-30 Variantes de empalme asociadas con mutantes neomórficos de SF3B1 Active ES2887201T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562212876P 2015-09-01 2015-09-01
PCT/US2016/049490 WO2017040526A2 (en) 2015-09-01 2016-08-30 Splice variants associated with neomorphic sf3b1 mutants

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ES2887201T3 true ES2887201T3 (es) 2021-12-22

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ES16766420T Active ES2887201T3 (es) 2015-09-01 2016-08-30 Variantes de empalme asociadas con mutantes neomórficos de SF3B1

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US (2) US10889866B2 (https=)
EP (2) EP3344780B1 (https=)
JP (2) JP6876680B2 (https=)
ES (1) ES2887201T3 (https=)
WO (1) WO2017040526A2 (https=)

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JP6876680B2 (ja) 2015-09-01 2021-05-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 ネオモルフィックsf3b1変異体に関連するスプライスバリアント
CA3056389A1 (en) * 2017-03-15 2018-09-20 Eisai R&D Management Co., Ltd. Spliceosome mutations and uses thereof
US12098172B2 (en) 2017-07-31 2024-09-24 The Johns Hopkins University Compositions and methods for targeting MASAs to treat cancers with spliceosome mutations
SG11202009906TA (en) * 2018-04-09 2020-11-27 Eisai R&D Man Co Ltd Pladienolide compounds and their use
CN119405832A (zh) 2018-06-01 2025-02-11 卫材R&D管理有限公司 剪接调节抗体-药物缀合物及其使用方法
EP3801523B1 (en) * 2018-06-01 2024-09-11 Eisai R&D Management Co., Ltd. Splicing modulators
IL262658A (en) * 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
JP6931860B2 (ja) * 2019-02-08 2021-09-08 株式会社Zenick mRNA前駆体の解析方法、情報処理装置、コンピュータプログラム
WO2020162613A1 (ja) * 2019-02-08 2020-08-13 株式会社Zenick mRNA前駆体の解析方法、情報処理装置、コンピュータプログラム
US20230159920A1 (en) * 2019-06-26 2023-05-25 Fred Hutchinson Cancer Research Center Methods and compositions comprising brd9 activating therapies for treating cancers and related disorders
CN111518805A (zh) * 2020-04-30 2020-08-11 北京航空航天大学 一种可用于抑制肿瘤增殖的非编码基因及其应用
ES2891182A1 (es) * 2020-07-14 2022-01-26 Servicio Andaluz De Salud Compuestos para el tratamiento del carcinoma hepatocelular
US20240043928A1 (en) 2020-11-04 2024-02-08 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
CN116507334A (zh) * 2020-11-04 2023-07-28 卫材R&D管理有限公司 骨髓增生异常综合征(mds)的生物标记物及其使用方法
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023209074A1 (en) * 2022-04-28 2023-11-02 Institut National de la Santé et de la Recherche Médicale Methods of restoring erythropoiesis in patients suffering from a sf3b1 mutant myelodysplastic syndrome by correcting coasy mis-splicing

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JP6876680B2 (ja) 2021-05-26
EP3910073A1 (en) 2021-11-17
EP3344780B1 (en) 2021-06-23
US11761045B2 (en) 2023-09-19
US20180318312A1 (en) 2018-11-08
JP7256840B2 (ja) 2023-04-12
EP3344780A2 (en) 2018-07-11
WO2017040526A3 (en) 2017-04-20
US10889866B2 (en) 2021-01-12
JP2018525994A (ja) 2018-09-13
WO2017040526A2 (en) 2017-03-09
EP3910073B1 (en) 2024-03-06
JP2021106615A (ja) 2021-07-29
US20210130909A1 (en) 2021-05-06

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