ES2871105T3 - Artículo que comprende una microaguja - Google Patents
Artículo que comprende una microaguja Download PDFInfo
- Publication number
- ES2871105T3 ES2871105T3 ES14747761T ES14747761T ES2871105T3 ES 2871105 T3 ES2871105 T3 ES 2871105T3 ES 14747761 T ES14747761 T ES 14747761T ES 14747761 T ES14747761 T ES 14747761T ES 2871105 T3 ES2871105 T3 ES 2871105T3
- Authority
- ES
- Spain
- Prior art keywords
- article
- microneedle
- microneedles
- tip
- platform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000007704 transition Effects 0.000 claims abstract description 37
- 230000002093 peripheral effect Effects 0.000 claims description 29
- 239000012530 fluid Substances 0.000 claims description 6
- 210000003491 skin Anatomy 0.000 description 84
- 239000007924 injection Substances 0.000 description 29
- 238000002347 injection Methods 0.000 description 29
- 239000010410 layer Substances 0.000 description 26
- 239000000463 material Substances 0.000 description 24
- 239000000853 adhesive Substances 0.000 description 22
- 230000001070 adhesive effect Effects 0.000 description 22
- 230000035515 penetration Effects 0.000 description 17
- 210000000434 stratum corneum Anatomy 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 229920000106 Liquid crystal polymer Polymers 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 9
- 229960000907 methylthioninium chloride Drugs 0.000 description 9
- 241000282898 Sus scrofa Species 0.000 description 8
- 238000001746 injection moulding Methods 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000003780 insertion Methods 0.000 description 6
- 230000037431 insertion Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 5
- 229940043267 rhodamine b Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004821 Contact adhesive Substances 0.000 description 4
- 241000252233 Cyprinus carpio Species 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 229920000515 polycarbonate Polymers 0.000 description 4
- 239000002195 soluble material Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 229920000954 Polyglycolide Polymers 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000004633 polyglycolic acid Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229920001707 polybutylene terephthalate Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000008257 shaving cream Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 210000003717 douglas' pouch Anatomy 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000012768 molten material Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- -1 polybutylene terephthalate Polymers 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000012776 robust process Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000012899 standard injection Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846909P | 2013-07-16 | 2013-07-16 | |
| PCT/US2014/046112 WO2015009531A1 (en) | 2013-07-16 | 2014-07-10 | Article comprising a microneedle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2871105T3 true ES2871105T3 (es) | 2021-10-28 |
Family
ID=51266428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14747761T Active ES2871105T3 (es) | 2013-07-16 | 2014-07-10 | Artículo que comprende una microaguja |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10201691B2 (enExample) |
| EP (1) | EP3021932B1 (enExample) |
| JP (2) | JP6602757B2 (enExample) |
| CN (1) | CN105407957A (enExample) |
| ES (1) | ES2871105T3 (enExample) |
| SG (2) | SG11201600330XA (enExample) |
| WO (1) | WO2015009531A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
| WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| US10384047B2 (en) | 2013-07-16 | 2019-08-20 | 3M Innovative Properties Company | Hollow microneedle with bevel opening |
| JP6651717B2 (ja) * | 2015-06-23 | 2020-02-19 | 凸版印刷株式会社 | 針状体の製造方法 |
| WO2017006958A1 (ja) * | 2015-07-07 | 2017-01-12 | 凸版印刷株式会社 | 経皮投与デバイス |
| CN105771082A (zh) * | 2016-04-07 | 2016-07-20 | 南通纺织丝绸产业技术研究院 | 一种空管丝素微针给药系统及其制备方法 |
| CN106422046A (zh) * | 2016-10-27 | 2017-02-22 | 游学秋 | 射流微针注射系统 |
| JP6977258B2 (ja) * | 2016-12-20 | 2021-12-08 | 株式会社リコー | 中空構造体 |
| JP1601442S (enExample) * | 2017-07-28 | 2018-04-09 | ||
| CN111526919B (zh) | 2017-12-19 | 2022-07-22 | 金德瓦药物控释有限公司 | 微阵列施用装置 |
| EP3727556A1 (en) | 2017-12-19 | 2020-10-28 | Kindeva Drug Delivery L.P. | Microarray applicator |
| EP3856321A1 (en) * | 2018-09-24 | 2021-08-04 | L'oreal | Device comprising microneedles for skin-coloring |
| US11577900B2 (en) | 2019-01-07 | 2023-02-14 | Kindeva Drug Delivery L.P. | Packaging for microarrays |
| JP7689708B2 (ja) * | 2019-06-25 | 2025-06-09 | コスメディ製薬株式会社 | 針密度が不均一なマイクロニードルアレイ |
| US20220241569A1 (en) * | 2019-06-25 | 2022-08-04 | Cosmed Pharmaceutical Co., Ltd. | Microneedle array having uneven needle density |
| US20220249821A1 (en) * | 2019-07-22 | 2022-08-11 | The Trustees Of Indiana University | Technologies for needles with microchannels |
| CN115734798A (zh) | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
| WO2021241486A1 (ja) * | 2020-05-25 | 2021-12-02 | コスメディ製薬株式会社 | 高性能マイクロニードルアレイ |
| US11389632B2 (en) | 2020-12-21 | 2022-07-19 | Mediccene Inc. | Intradermal drug delivery device |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| CN117547725A (zh) * | 2023-08-14 | 2024-02-13 | 重庆金赛星医疗科技有限公司 | 可溶性空心微针、微针阵列芯片及经皮给药贴片 |
| WO2025156134A1 (en) * | 2024-01-24 | 2025-07-31 | L'oreal | System with measurement component for safe transdermal delivery |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308822A (en) | 1964-04-02 | 1967-03-14 | Loretta Fontano | Hypodermic needle |
| US4490139A (en) | 1983-01-28 | 1984-12-25 | Eli Lilly And Company | Implant needle and method |
| US5575780A (en) | 1995-04-28 | 1996-11-19 | Saito; Yoshikuni | Medical hollow needle and a method of producing thereof |
| US5752942A (en) | 1996-06-20 | 1998-05-19 | Becton Dickinson And Company | Five beveled point geometry for a hypodermic needle |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| JP3492543B2 (ja) | 1999-03-15 | 2004-02-03 | 金子工業有限会社 | 注射針とその製造方法 |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6558361B1 (en) | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US7070583B1 (en) | 2000-07-03 | 2006-07-04 | Dr. Japan Co., Ltd. | Medical bevel needle |
| US6533949B1 (en) | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
| US6824378B2 (en) | 2002-05-31 | 2004-11-30 | 3M Innovative Properties Company | Microreplication tool with gas release features |
| MXPA05000597A (es) | 2002-07-19 | 2005-04-28 | 3M Innovative Properties Co | Dispositivos de microaguja y aparatos de administracion por microaguja. |
| EP1633250A2 (en) * | 2003-06-04 | 2006-03-15 | Georgia Tech Research Corporation | Drilling microneedle device |
| CA2534823A1 (en) * | 2003-08-04 | 2005-02-24 | Alza Corporation | Method and device for enhancing transdermal agent flux |
| US8353861B2 (en) | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
| WO2005044364A1 (en) | 2003-11-10 | 2005-05-19 | Agency For Science, Technology And Research | Microneedles and microneedle fabrication |
| US20090054842A1 (en) | 2003-11-18 | 2009-02-26 | Nanopass Technologies Ltd. | Enhanced penetration system and method for sliding microneedles |
| JP4500851B2 (ja) | 2004-03-12 | 2010-07-14 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | 横穴付きマイクロ針の製造に使用するための方法および型 |
| SE0402100D0 (sv) | 2004-08-30 | 2004-08-30 | Bonsens Ab | Molded micro-needles |
| CA2589733C (en) | 2004-12-07 | 2014-02-11 | 3M Innovative Properties Company | Method of molding a microneedle |
| US20100193997A1 (en) | 2005-06-10 | 2010-08-05 | Frederickson Franklyn L | Method of making a mold and molded article |
| WO2007112309A2 (en) | 2006-03-24 | 2007-10-04 | 3M Innovative Properties Company | Process for making microneedles, microneedle arrays, masters, and replication tools |
| WO2008020632A1 (en) | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Microneedle and microneedle patch |
| US20090326415A1 (en) * | 2006-08-28 | 2009-12-31 | Agency For Science ,Technology And Research | Microneedles and methods for fabricating microneedles |
| KR100911488B1 (ko) * | 2007-09-07 | 2009-08-11 | 호남석유화학 주식회사 | 미세 바늘 및 미세 바늘 어레이 |
| CN101244303B (zh) | 2008-02-22 | 2010-09-01 | 清华大学 | 微型实心或空心硅针、硅针阵列及其制造方法 |
| WO2009130926A1 (ja) | 2008-04-22 | 2009-10-29 | 南部化成株式会社 | 経皮投薬方法、ニードル形成体及び経皮投薬装置 |
| NL2001718C2 (nl) | 2008-06-24 | 2009-12-28 | Needle Holding B V U | Micronaald, micronaaldarray en fabricagewerkwijze daarvoor. |
| DE102008052749B4 (de) * | 2008-10-22 | 2012-01-12 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Nadel, Nadelanordnung, Spritzgussform und Verfahren zum Herstellen |
| CN105999538A (zh) | 2008-11-18 | 2016-10-12 | 3M创新有限公司 | 空心微针阵列和方法 |
| CN101856538B (zh) * | 2009-04-09 | 2012-06-20 | 香港理工大学 | 微针阵列、制造该微针阵列的模铸方法及所使用的模具 |
| EP2416835B1 (en) * | 2009-04-10 | 2019-05-15 | 3M Innovative Properties Company | Methods of making hollow microneedle arrays |
| US10010706B2 (en) | 2009-07-31 | 2018-07-03 | 3M Innovative Properties Company | Hollow microneedle arrays |
| US8088108B2 (en) * | 2009-08-22 | 2012-01-03 | Joseph Wayne Kraft | Rapid local anesthesia injection cone |
| JP5558772B2 (ja) | 2009-10-08 | 2014-07-23 | 東レエンジニアリング株式会社 | マイクロニードルシートのスタンパー及びその製造方法とそれを用いたマイクロニードルの製造方法 |
| CN102770256B (zh) | 2009-12-18 | 2016-08-24 | 3M创新有限公司 | 模制热致性液晶聚合物及由其制成的制品 |
| US20110172637A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| ES2561824T3 (es) * | 2010-07-16 | 2016-03-01 | Seventh Sense Biosystems, Inc. | Ambiente a baja presión para dispositivos de transferencia de fluidos |
| JP5770055B2 (ja) | 2010-09-29 | 2015-08-26 | 富士フイルム株式会社 | 針状アレイ経皮吸収シートの製造方法 |
| WO2012048285A1 (en) * | 2010-10-08 | 2012-04-12 | Lanco Biosciences, Inc. | Delivery of bisphosphonates by microinjection systems |
| ES2580834T3 (es) | 2010-12-02 | 2016-08-29 | 3M Innovative Properties Company | Microagujas de polímero cristalino líquido |
| US20140066842A1 (en) | 2011-03-07 | 2014-03-06 | 3M Innovative Properties Company | Microneedle devices and methods |
| EP2686058A1 (en) | 2011-03-18 | 2014-01-22 | Université Libre de Bruxelles | Devices for puncturing a human or animal body's membrane |
| JP6119609B2 (ja) | 2011-10-28 | 2017-04-26 | 凸版印刷株式会社 | 中空針状体の製造方法,中空針状体および中空針状体送液システム |
| EP3513833A1 (en) | 2012-12-21 | 2019-07-24 | 3M Innovative Properties Co. | Adhesive assemblies and microneedle injection apparatus comprising same |
| EP2938390A1 (en) | 2012-12-27 | 2015-11-04 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
| US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
| WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| US10384047B2 (en) | 2013-07-16 | 2019-08-20 | 3M Innovative Properties Company | Hollow microneedle with bevel opening |
-
2014
- 2014-07-10 SG SG11201600330XA patent/SG11201600330XA/en unknown
- 2014-07-10 WO PCT/US2014/046112 patent/WO2015009531A1/en not_active Ceased
- 2014-07-10 CN CN201480040113.2A patent/CN105407957A/zh active Pending
- 2014-07-10 JP JP2016526989A patent/JP6602757B2/ja active Active
- 2014-07-10 ES ES14747761T patent/ES2871105T3/es active Active
- 2014-07-10 US US14/904,998 patent/US10201691B2/en active Active
- 2014-07-10 SG SG10201710909YA patent/SG10201710909YA/en unknown
- 2014-07-10 EP EP14747761.6A patent/EP3021932B1/en active Active
-
2018
- 2018-12-14 US US16/221,130 patent/US10576257B2/en active Active
-
2019
- 2019-02-01 JP JP2019016615A patent/JP2019103822A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201600330XA (en) | 2016-02-26 |
| EP3021932B1 (en) | 2021-03-24 |
| JP2019103822A (ja) | 2019-06-27 |
| WO2015009531A1 (en) | 2015-01-22 |
| US20190117948A1 (en) | 2019-04-25 |
| US20160151616A1 (en) | 2016-06-02 |
| US10576257B2 (en) | 2020-03-03 |
| JP6602757B2 (ja) | 2019-11-06 |
| JP2016527001A (ja) | 2016-09-08 |
| EP3021932A1 (en) | 2016-05-25 |
| SG10201710909YA (en) | 2018-02-27 |
| US10201691B2 (en) | 2019-02-12 |
| CN105407957A (zh) | 2016-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2871105T3 (es) | Artículo que comprende una microaguja | |
| ES2885923T3 (es) | Conjunto de microagujas | |
| EP3021931B1 (en) | Hollow microneedle array article | |
| JP6612952B2 (ja) | 斜角開口部を有する中空マイクロニードル | |
| US10232157B2 (en) | Hollow microneedle with beveled tip | |
| CN221732101U (zh) | 一种可分离式微针系统及模具 |