ES2862730T3 - Combinación de un inhibidor de isocitrato deshidrogenasa 2 mutante con azacitidina y su uso para el tratamiento de la leucemia mielógena aguda - Google Patents

Info

Publication number

ES2862730T3

ES2862730T3 ES16788866T ES16788866T ES2862730T3 ES 2862730 T3 ES2862730 T3 ES 2862730T3 ES 16788866 T ES16788866 T ES 16788866T ES 16788866 T ES16788866 T ES 16788866T ES 2862730 T3 ES2862730 T3 ES 2862730T3

Authority

ES

Spain

Prior art keywords

compound

azacitidine

day

idh2

subject

Prior art date

2015-10-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Active

Links

• Espacenet
• Global Dossier
• Discuss

• NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 title claims abstract description 400
• 229960002756 azacitidine Drugs 0.000 title claims abstract description 388
• 208000031261 Acute myeloid leukaemia Diseases 0.000 title claims abstract description 127
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 title claims abstract description 123
• 238000011282 treatment Methods 0.000 title description 190
• 229940124202 Isocitrate dehydrogenase 2 inhibitor Drugs 0.000 title description 2
• 229940125904 compound 1 Drugs 0.000 claims abstract description 332
• 238000000034 method Methods 0.000 claims abstract description 112
• 108700028369 Alleles Proteins 0.000 claims abstract description 53
• 150000003839 salts Chemical class 0.000 claims abstract description 35
• 239000003112 inhibitor Substances 0.000 claims abstract description 32
• 239000012453 solvate Substances 0.000 claims abstract description 30
• 108010075869 Isocitrate Dehydrogenase Proteins 0.000 claims abstract description 20
• 102000012011 Isocitrate Dehydrogenase Human genes 0.000 claims abstract description 20
• DYLUUSLLRIQKOE-UHFFFAOYSA-N enasidenib Chemical group N=1C(C=2N=C(C=CC=2)C(F)(F)F)=NC(NCC(C)(O)C)=NC=1NC1=CC=NC(C(F)(F)F)=C1 DYLUUSLLRIQKOE-UHFFFAOYSA-N 0.000 claims abstract description 10
• 230000035772 mutation Effects 0.000 claims description 71
• 239000008194 pharmaceutical composition Substances 0.000 claims description 61
• 102200116484 rs121913502 Human genes 0.000 claims description 13
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
• RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims description 9
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 5
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
• 229940055764 triaz Drugs 0.000 claims description 2
• 239000003814 drug Substances 0.000 description 221
• 229940079593 drug Drugs 0.000 description 212
• 239000000203 mixture Substances 0.000 description 107
• 229940125782 compound 2 Drugs 0.000 description 73
• 201000003793 Myelodysplastic syndrome Diseases 0.000 description 67
• 238000009472 formulation Methods 0.000 description 61
• 230000004044 response Effects 0.000 description 56
• 206010028980 Neoplasm Diseases 0.000 description 54
• 230000002354 daily effect Effects 0.000 description 52
• 210000004027 cell Anatomy 0.000 description 48
• 150000001875 compounds Chemical class 0.000 description 44
• HWXBTNAVRSUOJR-UHFFFAOYSA-N 2-hydroxyglutaric acid Chemical compound OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 description 40
• 235000002639 sodium chloride Nutrition 0.000 description 40
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 34
• UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 34
• 239000003795 chemical substances by application Substances 0.000 description 32
• 239000003826 tablet Substances 0.000 description 32
• 208000002250 Hematologic Neoplasms Diseases 0.000 description 31
• 230000000694 effects Effects 0.000 description 31
• 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 description 30
• 239000000546 pharmaceutical excipient Substances 0.000 description 29
• 238000002560 therapeutic procedure Methods 0.000 description 29
• 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 description 28
• 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 description 28
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 27
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
• 210000001185 bone marrow Anatomy 0.000 description 25
• 239000007787 solid Substances 0.000 description 24
• 238000011156 evaluation Methods 0.000 description 23
• -1 zebularin Chemical compound 0.000 description 22
• 201000010099 disease Diseases 0.000 description 21
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 21
• 238000012552 review Methods 0.000 description 21
• 239000000243 solution Substances 0.000 description 21
• 201000005787 hematologic cancer Diseases 0.000 description 19
• 238000002360 preparation method Methods 0.000 description 19
• 201000011510 cancer Diseases 0.000 description 18
• 239000002775 capsule Substances 0.000 description 18
• 230000004069 differentiation Effects 0.000 description 18
• 238000012216 screening Methods 0.000 description 18
• 206010025323 Lymphomas Diseases 0.000 description 17
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 17
• 210000002966 serum Anatomy 0.000 description 17
• 210000002784 stomach Anatomy 0.000 description 17
• 239000012650 DNA demethylating agent Substances 0.000 description 16
• 229940045805 DNA demethylating agent Drugs 0.000 description 16
• 102000003951 Erythropoietin Human genes 0.000 description 16
• 108090000394 Erythropoietin Proteins 0.000 description 16
• 238000006243 chemical reaction Methods 0.000 description 16
• 239000003085 diluting agent Substances 0.000 description 16
• 229940105423 erythropoietin Drugs 0.000 description 16
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 16
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
• 206010002449 angioimmunoblastic T-cell lymphoma Diseases 0.000 description 15
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 15
• 238000000634 powder X-ray diffraction Methods 0.000 description 15
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 14
• 210000004369 blood Anatomy 0.000 description 14
• 239000008280 blood Substances 0.000 description 14
• 238000002483 medication Methods 0.000 description 14
• 210000005259 peripheral blood Anatomy 0.000 description 14
• 239000011886 peripheral blood Substances 0.000 description 14
• 238000009097 single-agent therapy Methods 0.000 description 14
• 230000004083 survival effect Effects 0.000 description 14
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
• 239000012729 immediate-release (IR) formulation Substances 0.000 description 13
• 230000006872 improvement Effects 0.000 description 13
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 13
• XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 12
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
• 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 description 12
• 239000011230 binding agent Substances 0.000 description 12
• 238000001514 detection method Methods 0.000 description 12
• 239000007884 disintegrant Substances 0.000 description 12
• 239000000314 lubricant Substances 0.000 description 12
• 239000011541 reaction mixture Substances 0.000 description 12
• 239000000725 suspension Substances 0.000 description 12
• 201000010902 chronic myelomonocytic leukemia Diseases 0.000 description 11
• 239000002552 dosage form Substances 0.000 description 11
• 208000032839 leukemia Diseases 0.000 description 11
• AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical group C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 11
• 239000000843 powder Substances 0.000 description 11
• 239000002904 solvent Substances 0.000 description 11
• 238000007920 subcutaneous administration Methods 0.000 description 11
• 208000024891 symptom Diseases 0.000 description 11
• 238000012360 testing method Methods 0.000 description 11
• 206010061818 Disease progression Diseases 0.000 description 10
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 10
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 10
• 201000007224 Myeloproliferative neoplasm Diseases 0.000 description 10
• 229920002472 Starch Polymers 0.000 description 10
• 238000004458 analytical method Methods 0.000 description 10
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 10
• 125000004122 cyclic group Chemical group 0.000 description 10
• 230000005750 disease progression Effects 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 238000004519 manufacturing process Methods 0.000 description 10
• 239000002207 metabolite Substances 0.000 description 10
• 230000009826 neoplastic cell growth Effects 0.000 description 10
• 230000036470 plasma concentration Effects 0.000 description 10
• 235000019698 starch Nutrition 0.000 description 10
• 206010008583 Chloroma Diseases 0.000 description 9
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 9
• 208000034578 Multiple myelomas Diseases 0.000 description 9
• 206010035226 Plasma cell myeloma Diseases 0.000 description 9
• 206010042971 T-cell lymphoma Diseases 0.000 description 9
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 9
• 239000008186 active pharmaceutical agent Substances 0.000 description 9
• 238000001574 biopsy Methods 0.000 description 9
• 230000015572 biosynthetic process Effects 0.000 description 9
• 230000012010 growth Effects 0.000 description 9
• 230000002489 hematologic effect Effects 0.000 description 9
• 201000005987 myeloid sarcoma Diseases 0.000 description 9
• 239000003381 stabilizer Substances 0.000 description 9
• 239000008107 starch Substances 0.000 description 9
• 229940032147 starch Drugs 0.000 description 9
• 239000003981 vehicle Substances 0.000 description 9
• 208000005243 Chondrosarcoma Diseases 0.000 description 8
• 208000032612 Glial tumor Diseases 0.000 description 8
• 206010018338 Glioma Diseases 0.000 description 8
• 208000009527 Refractory anemia Diseases 0.000 description 8
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 8
• 239000000654 additive Substances 0.000 description 8
• 239000001913 cellulose Substances 0.000 description 8
• 208000006990 cholangiocarcinoma Diseases 0.000 description 8
• 239000003433 contraceptive agent Substances 0.000 description 8
• 229960003603 decitabine Drugs 0.000 description 8
• 230000001419 dependent effect Effects 0.000 description 8
• 231100000371 dose-limiting toxicity Toxicity 0.000 description 8
• 230000014509 gene expression Effects 0.000 description 8
• 238000001802 infusion Methods 0.000 description 8
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
• 239000000463 material Substances 0.000 description 8
• 201000001441 melanoma Diseases 0.000 description 8
• 230000004048 modification Effects 0.000 description 8
• 238000012986 modification Methods 0.000 description 8
• 210000000056 organ Anatomy 0.000 description 8
• 238000009597 pregnancy test Methods 0.000 description 8
• 230000002829 reductive effect Effects 0.000 description 8
• 239000011734 sodium Substances 0.000 description 8
• 229940124597 therapeutic agent Drugs 0.000 description 8
• 230000001225 therapeutic effect Effects 0.000 description 8
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 7
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 7
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 7
• 239000013543 active substance Substances 0.000 description 7
• 239000002671 adjuvant Substances 0.000 description 7
• 150000001413 amino acids Chemical class 0.000 description 7
• 230000006907 apoptotic process Effects 0.000 description 7
• 238000003556 assay Methods 0.000 description 7
• 208000035269 cancer or benign tumor Diseases 0.000 description 7
• 239000001768 carboxy methyl cellulose Substances 0.000 description 7
• 210000003169 central nervous system Anatomy 0.000 description 7
• 230000034994 death Effects 0.000 description 7
• 230000007423 decrease Effects 0.000 description 7
• 238000003745 diagnosis Methods 0.000 description 7
• 239000012458 free base Substances 0.000 description 7
• 230000002496 gastric effect Effects 0.000 description 7
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 7
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 7
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 7
• 230000006698 induction Effects 0.000 description 7
• 230000000977 initiatory effect Effects 0.000 description 7
• 231100000682 maximum tolerated dose Toxicity 0.000 description 7
• 230000000877 morphologic effect Effects 0.000 description 7
• 239000006186 oral dosage form Substances 0.000 description 7
• 229920001223 polyethylene glycol Polymers 0.000 description 7
• 229920000642 polymer Polymers 0.000 description 7
• 239000000651 prodrug Substances 0.000 description 7
• 229940002612 prodrug Drugs 0.000 description 7
• 230000009467 reduction Effects 0.000 description 7
• 239000000523 sample Substances 0.000 description 7
• 239000011780 sodium chloride Substances 0.000 description 7
• 239000011550 stock solution Substances 0.000 description 7
• 230000000699 topical effect Effects 0.000 description 7
• 231100000419 toxicity Toxicity 0.000 description 7
• 230000001988 toxicity Effects 0.000 description 7
• 108010003415 Aspartate Aminotransferases Proteins 0.000 description 6
• 102000004625 Aspartate Aminotransferases Human genes 0.000 description 6
• 229910016523 CuKa Inorganic materials 0.000 description 6
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 6
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
• 102000004190 Enzymes Human genes 0.000 description 6
• 108090000790 Enzymes Proteins 0.000 description 6
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
• 102100022248 Krueppel-like factor 1 Human genes 0.000 description 6
• 229930195725 Mannitol Natural products 0.000 description 6
• 239000002202 Polyethylene glycol Substances 0.000 description 6
• 238000011529 RT qPCR Methods 0.000 description 6
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
• 230000000996 additive effect Effects 0.000 description 6
• 229940024606 amino acid Drugs 0.000 description 6
• 235000001014 amino acid Nutrition 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• 239000000872 buffer Substances 0.000 description 6
• OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 6
• 230000030833 cell death Effects 0.000 description 6
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 6
• 230000002254 contraceptive effect Effects 0.000 description 6
• 238000013270 controlled release Methods 0.000 description 6
• 238000013461 design Methods 0.000 description 6
• 108010089558 erythroid Kruppel-like factor Proteins 0.000 description 6
• 239000007888 film coating Substances 0.000 description 6
• 238000009501 film coating Methods 0.000 description 6
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 239000000594 mannitol Substances 0.000 description 6
• 235000010355 mannitol Nutrition 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 239000012299 nitrogen atmosphere Substances 0.000 description 6
• 230000005855 radiation Effects 0.000 description 6
• 210000000130 stem cell Anatomy 0.000 description 6
• UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 5
• IDYKCXHJJGMAEV-RRKCRQDMSA-N 4-amino-5-fluoro-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound C1=C(F)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 IDYKCXHJJGMAEV-RRKCRQDMSA-N 0.000 description 5
• 108700012813 7-aminoactinomycin D Proteins 0.000 description 5
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
• 229920000858 Cyclodextrin Polymers 0.000 description 5
• UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 5
• 108010010803 Gelatin Proteins 0.000 description 5
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 5
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 5
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
• 230000005856 abnormality Effects 0.000 description 5
• 238000010521 absorption reaction Methods 0.000 description 5
• 235000010443 alginic acid Nutrition 0.000 description 5
• 229920000615 alginic acid Polymers 0.000 description 5
• 210000003719 b-lymphocyte Anatomy 0.000 description 5
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
• 229940105329 carboxymethylcellulose Drugs 0.000 description 5
• 239000000969 carrier Substances 0.000 description 5
• 235000010980 cellulose Nutrition 0.000 description 5
• 229920002678 cellulose Polymers 0.000 description 5
• 229940075614 colloidal silicon dioxide Drugs 0.000 description 5
• 238000011284 combination treatment Methods 0.000 description 5
• 229940109239 creatinine Drugs 0.000 description 5
• 230000002559 cytogenic effect Effects 0.000 description 5
• 238000011161 development Methods 0.000 description 5
• 230000018109 developmental process Effects 0.000 description 5
• 239000008121 dextrose Substances 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• 239000003623 enhancer Substances 0.000 description 5
• 238000000684 flow cytometry Methods 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 229940014259 gelatin Drugs 0.000 description 5
• 239000007903 gelatin capsule Substances 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 230000036541 health Effects 0.000 description 5
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 5
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 5
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
• 238000001990 intravenous administration Methods 0.000 description 5
• 230000000155 isotopic effect Effects 0.000 description 5
• 239000008101 lactose Substances 0.000 description 5
• 229960001375 lactose Drugs 0.000 description 5
• 229940016286 microcrystalline cellulose Drugs 0.000 description 5
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 5
• 239000008108 microcrystalline cellulose Substances 0.000 description 5
• 210000002381 plasma Anatomy 0.000 description 5
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
• 230000001568 sexual effect Effects 0.000 description 5
• 235000015424 sodium Nutrition 0.000 description 5
• 229910052708 sodium Inorganic materials 0.000 description 5
• 238000010186 staining Methods 0.000 description 5
• 238000003756 stirring Methods 0.000 description 5
• 239000000126 substance Substances 0.000 description 5
• 238000003786 synthesis reaction Methods 0.000 description 5
• KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 4
• JBXAKQJKSGOFNP-UHFFFAOYSA-N 6-[6-(trifluoromethyl)pyridin-2-yl]-1h-1,3,5-triazine-2,4-dione Chemical compound FC(F)(F)C1=CC=CC(C=2NC(=O)NC(=O)N=2)=N1 JBXAKQJKSGOFNP-UHFFFAOYSA-N 0.000 description 4
• 208000004476 Acute Coronary Syndrome Diseases 0.000 description 4
• 108010082126 Alanine transaminase Proteins 0.000 description 4
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
• 101150015280 Cel gene Proteins 0.000 description 4
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
• 239000001856 Ethyl cellulose Substances 0.000 description 4
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
• 206010019280 Heart failures Diseases 0.000 description 4
• 241000711549 Hepacivirus C Species 0.000 description 4
• 101000823298 Homo sapiens Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 description 4
• 241000725303 Human immunodeficiency virus Species 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 4
• 239000005913 Maltodextrin Substances 0.000 description 4
• 229920002774 Maltodextrin Polymers 0.000 description 4
• 229920000881 Modified starch Polymers 0.000 description 4
• DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 4
• 208000033501 Refractory anemia with excess blasts Diseases 0.000 description 4
• 206010039491 Sarcoma Diseases 0.000 description 4
• 102100035476 Serum paraoxonase/arylesterase 1 Human genes 0.000 description 4
• 229930006000 Sucrose Natural products 0.000 description 4
• 208000036142 Viral infection Diseases 0.000 description 4
• 239000002253 acid Substances 0.000 description 4
• 230000002411 adverse Effects 0.000 description 4
• 125000000129 anionic group Chemical group 0.000 description 4
• 239000003242 anti bacterial agent Substances 0.000 description 4
• 229940088710 antibiotic agent Drugs 0.000 description 4
• 239000003125 aqueous solvent Substances 0.000 description 4
• 230000036772 blood pressure Effects 0.000 description 4
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 4
• 230000015556 catabolic process Effects 0.000 description 4
• 238000002512 chemotherapy Methods 0.000 description 4
• 230000001351 cycling effect Effects 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 238000006731 degradation reaction Methods 0.000 description 4
• 230000001934 delay Effects 0.000 description 4
• 210000004443 dendritic cell Anatomy 0.000 description 4
• FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 4
• 239000002270 dispersing agent Substances 0.000 description 4
• 231100000673 dose–response relationship Toxicity 0.000 description 4
• 235000019325 ethyl cellulose Nutrition 0.000 description 4
• 229920001249 ethyl cellulose Polymers 0.000 description 4
• 239000011521 glass Substances 0.000 description 4
• 229960001330 hydroxycarbamide Drugs 0.000 description 4
• 230000001771 impaired effect Effects 0.000 description 4
• 208000015181 infectious disease Diseases 0.000 description 4
• 230000002401 inhibitory effect Effects 0.000 description 4
• 239000010410 layer Substances 0.000 description 4
• 238000000707 layer-by-layer assembly Methods 0.000 description 4
• 239000000391 magnesium silicate Substances 0.000 description 4
• 235000019359 magnesium stearate Nutrition 0.000 description 4
• 229940035034 maltodextrin Drugs 0.000 description 4
• 239000011159 matrix material Substances 0.000 description 4
• 208000016586 myelodysplastic syndrome with excess blasts Diseases 0.000 description 4
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 4
• 231100000252 nontoxic Toxicity 0.000 description 4
• 230000003000 nontoxic effect Effects 0.000 description 4
• 230000036961 partial effect Effects 0.000 description 4
• 230000001575 pathological effect Effects 0.000 description 4
• 230000007170 pathology Effects 0.000 description 4
• 239000008188 pellet Substances 0.000 description 4
• 239000003961 penetration enhancing agent Substances 0.000 description 4
• 210000005134 plasmacytoid dendritic cell Anatomy 0.000 description 4
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
• 235000019814 powdered cellulose Nutrition 0.000 description 4
• 229920003124 powdered cellulose Polymers 0.000 description 4
• 230000008569 process Effects 0.000 description 4
• 229960004063 propylene glycol Drugs 0.000 description 4
• 108090000623 proteins and genes Proteins 0.000 description 4
• 238000010992 reflux Methods 0.000 description 4
• 206010067959 refractory cytopenia with multilineage dysplasia Diseases 0.000 description 4
• 230000035945 sensitivity Effects 0.000 description 4
• 239000000600 sorbitol Substances 0.000 description 4
• 235000010356 sorbitol Nutrition 0.000 description 4
• 238000010254 subcutaneous injection Methods 0.000 description 4
• 239000007929 subcutaneous injection Substances 0.000 description 4
• 239000000758 substrate Substances 0.000 description 4
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• 229960004793 sucrose Drugs 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 230000009885 systemic effect Effects 0.000 description 4
• 239000000454 talc Substances 0.000 description 4
• 229910052623 talc Inorganic materials 0.000 description 4
• 229940033134 talc Drugs 0.000 description 4
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 4
• 210000002700 urine Anatomy 0.000 description 4
• 230000009385 viral infection Effects 0.000 description 4
• 239000001993 wax Substances 0.000 description 4
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 3
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
• GSSCQXYNRDFGAV-UHFFFAOYSA-N 2,4-dichloro-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(Cl)N=C(Cl)N=2)=N1 GSSCQXYNRDFGAV-UHFFFAOYSA-N 0.000 description 3
• OKBHXGBLXDNJJD-UHFFFAOYSA-N 6-(trifluoromethyl)pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(C(F)(F)F)=N1 OKBHXGBLXDNJJD-UHFFFAOYSA-N 0.000 description 3
• YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 description 3
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 3
• 239000005995 Aluminium silicate Substances 0.000 description 3
• 108090000672 Annexin A5 Proteins 0.000 description 3
• 102000004121 Annexin A5 Human genes 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• 239000004375 Dextrin Substances 0.000 description 3
• 229920001353 Dextrin Polymers 0.000 description 3
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
• XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 3
• 229920002907 Guar gum Polymers 0.000 description 3
• 108010054147 Hemoglobins Proteins 0.000 description 3
• 102000001554 Hemoglobins Human genes 0.000 description 3
• 101150104906 Idh2 gene Proteins 0.000 description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
• 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 description 3
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
• 240000007472 Leucaena leucocephala Species 0.000 description 3
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
• 239000000783 alginic acid Substances 0.000 description 3
• 229960001126 alginic acid Drugs 0.000 description 3
• 150000004781 alginic acids Chemical class 0.000 description 3
• 235000012211 aluminium silicate Nutrition 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 210000001124 body fluid Anatomy 0.000 description 3
• 239000012267 brine Substances 0.000 description 3
• 235000013539 calcium stearate Nutrition 0.000 description 3
• 239000008116 calcium stearate Substances 0.000 description 3
• 229940078456 calcium stearate Drugs 0.000 description 3
• 229940095672 calcium sulfate Drugs 0.000 description 3
• 235000011132 calcium sulphate Nutrition 0.000 description 3
• 150000001768 cations Chemical class 0.000 description 3
• 230000010261 cell growth Effects 0.000 description 3
• 239000003086 colorant Substances 0.000 description 3
• 238000002648 combination therapy Methods 0.000 description 3
• 239000002131 composite material Substances 0.000 description 3
• 238000007906 compression Methods 0.000 description 3
• 230000006835 compression Effects 0.000 description 3
• 238000012790 confirmation Methods 0.000 description 3
• 239000013078 crystal Substances 0.000 description 3
• 229940097362 cyclodextrins Drugs 0.000 description 3
• 229940096516 dextrates Drugs 0.000 description 3
• 235000019425 dextrin Nutrition 0.000 description 3
• 238000009826 distribution Methods 0.000 description 3
• 230000009977 dual effect Effects 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 3
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 3
• 229930195712 glutamate Natural products 0.000 description 3
• 239000008187 granular material Substances 0.000 description 3
• 235000010417 guar gum Nutrition 0.000 description 3
• 239000000665 guar gum Substances 0.000 description 3
• 229960002154 guar gum Drugs 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 238000007918 intramuscular administration Methods 0.000 description 3
• ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 3
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
• 210000000265 leukocyte Anatomy 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• 229910052749 magnesium Inorganic materials 0.000 description 3
• 235000001055 magnesium Nutrition 0.000 description 3
• 229940091250 magnesium supplement Drugs 0.000 description 3
• 235000019793 magnesium trisilicate Nutrition 0.000 description 3
• 229940099273 magnesium trisilicate Drugs 0.000 description 3
• 229910000386 magnesium trisilicate Inorganic materials 0.000 description 3
• 238000005259 measurement Methods 0.000 description 3
• AYABEJGGSWJVPN-UHFFFAOYSA-N methyl 6-(trifluoromethyl)pyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(C(F)(F)F)=N1 AYABEJGGSWJVPN-UHFFFAOYSA-N 0.000 description 3
• 229920000609 methyl cellulose Polymers 0.000 description 3
• 235000010981 methylcellulose Nutrition 0.000 description 3
• 239000001923 methylcellulose Substances 0.000 description 3
• 229960002900 methylcellulose Drugs 0.000 description 3
• 230000000869 mutational effect Effects 0.000 description 3
• 210000000440 neutrophil Anatomy 0.000 description 3
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
• 239000003921 oil Substances 0.000 description 3
• 235000019198 oils Nutrition 0.000 description 3
• IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
• 235000021317 phosphate Nutrition 0.000 description 3
• 229940113116 polyethylene glycol 1000 Drugs 0.000 description 3
• SWWHCQCMVCPLEQ-UHFFFAOYSA-N propan-2-yl methanesulfonate Chemical compound CC(C)OS(C)(=O)=O SWWHCQCMVCPLEQ-UHFFFAOYSA-N 0.000 description 3
• 235000018102 proteins Nutrition 0.000 description 3
• 102000004169 proteins and genes Human genes 0.000 description 3
• 238000011084 recovery Methods 0.000 description 3
• 230000007115 recruitment Effects 0.000 description 3
• 239000013049 sediment Substances 0.000 description 3
• 229940005550 sodium alginate Drugs 0.000 description 3
• 235000010413 sodium alginate Nutrition 0.000 description 3
• 239000000661 sodium alginate Substances 0.000 description 3
• 235000017557 sodium bicarbonate Nutrition 0.000 description 3
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 230000003319 supportive effect Effects 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• 208000016595 therapy related acute myeloid leukemia and myelodysplastic syndrome Diseases 0.000 description 3
• 238000012546 transfer Methods 0.000 description 3
• 238000011269 treatment regimen Methods 0.000 description 3
• 235000019731 tricalcium phosphate Nutrition 0.000 description 3
• 229940065658 vidaza Drugs 0.000 description 3
• 239000000080 wetting agent Substances 0.000 description 3
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
• PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical class CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
• GMHKMTDVRCWUDX-LBPRGKRZSA-N (S)-Mephenytoin Chemical compound C=1C=CC=CC=1[C@]1(CC)NC(=O)N(C)C1=O GMHKMTDVRCWUDX-LBPRGKRZSA-N 0.000 description 2
• OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
• CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• MPDKOGQMQLSNOF-GBNDHIKLSA-N 2-amino-5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrimidin-6-one Chemical compound O=C1NC(N)=NC=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 MPDKOGQMQLSNOF-GBNDHIKLSA-N 0.000 description 2
• 108010057379 2-hydroxyglutarate dehydrogenase Proteins 0.000 description 2
• 201000006753 2-hydroxyglutaric aciduria Diseases 0.000 description 2
• SXFBKPOTJNVNEW-UHFFFAOYSA-N 4-chloro-n-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazin-2-amine Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(NC=3C=C(N=CC=3)C(F)(F)F)N=C(Cl)N=2)=N1 SXFBKPOTJNVNEW-UHFFFAOYSA-N 0.000 description 2
• LJIRBXZDQGQUOO-KVTDHHQDSA-N 6-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydro-1,3,5-triazin-2-one Chemical compound C1NC(N)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 LJIRBXZDQGQUOO-KVTDHHQDSA-N 0.000 description 2
• 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
• 208000035143 Bacterial infection Diseases 0.000 description 2
• 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 2
• 206010007559 Cardiac failure congestive Diseases 0.000 description 2
• 102000047934 Caspase-3/7 Human genes 0.000 description 2
• 108700037887 Caspase-3/7 Proteins 0.000 description 2
• 235000013913 Ceratonia Nutrition 0.000 description 2
• 241001060815 Ceratonia Species 0.000 description 2
• 229920001661 Chitosan Polymers 0.000 description 2
• 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
• 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
• 208000031404 Chromosome Aberrations Diseases 0.000 description 2
• 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 description 2
• 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 description 2
• 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 description 2
• 102100026533 Cytochrome P450 1A2 Human genes 0.000 description 2
• 102100029363 Cytochrome P450 2C19 Human genes 0.000 description 2
• 102100029358 Cytochrome P450 2C9 Human genes 0.000 description 2
• 108020004414 DNA Proteins 0.000 description 2
• 230000007067 DNA methylation Effects 0.000 description 2
• 208000019505 Deglutition disease Diseases 0.000 description 2
• CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 description 2
• QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
• 238000000729 Fisher's exact test Methods 0.000 description 2
• 241001069765 Fridericia <angiosperm> Species 0.000 description 2
• 206010064571 Gene mutation Diseases 0.000 description 2
• 208000009139 Gilbert Disease Diseases 0.000 description 2
• 208000022412 Gilbert syndrome Diseases 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
• 101150086355 HBG gene Proteins 0.000 description 2
• 208000032843 Hemorrhage Diseases 0.000 description 2
• 241000700721 Hepatitis B virus Species 0.000 description 2
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
• 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 206010020772 Hypertension Diseases 0.000 description 2
• 208000019025 Hypokalemia Diseases 0.000 description 2
• 206010021143 Hypoxia Diseases 0.000 description 2
• 101150020771 IDH gene Proteins 0.000 description 2
• 206010021518 Impaired gastric emptying Diseases 0.000 description 2
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
• CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 2
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
• 206010035664 Pneumonia Diseases 0.000 description 2
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
• 229920001100 Polydextrose Polymers 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 2
• ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
• 206010060862 Prostate cancer Diseases 0.000 description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
• 206010049416 Short-bowel syndrome Diseases 0.000 description 2
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
• 229920002125 Sokalan® Polymers 0.000 description 2
• 235000021355 Stearic acid Nutrition 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 2
• AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 2
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
• 102100029152 UDP-glucuronosyltransferase 1A1 Human genes 0.000 description 2
• 101710205316 UDP-glucuronosyltransferase 1A1 Proteins 0.000 description 2
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
• 208000026935 allergic disease Diseases 0.000 description 2
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
• CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 2
• 229940063655 aluminum stearate Drugs 0.000 description 2
• 235000010407 ammonium alginate Nutrition 0.000 description 2
• 239000000728 ammonium alginate Substances 0.000 description 2
• KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 2
• 229950000242 ancitabine Drugs 0.000 description 2
• 230000000840 anti-viral effect Effects 0.000 description 2
• 238000011319 anticancer therapy Methods 0.000 description 2
• 230000002763 arrhythmic effect Effects 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 208000022362 bacterial infectious disease Diseases 0.000 description 2
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
• 230000002146 bilateral effect Effects 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 208000034158 bleeding Diseases 0.000 description 2
• 230000000740 bleeding effect Effects 0.000 description 2
• 239000010839 body fluid Substances 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 201000005389 breast carcinoma in situ Diseases 0.000 description 2
• HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 235000010410 calcium alginate Nutrition 0.000 description 2
• 239000000648 calcium alginate Substances 0.000 description 2
• 229960002681 calcium alginate Drugs 0.000 description 2
• 229910000019 calcium carbonate Inorganic materials 0.000 description 2
• 235000010216 calcium carbonate Nutrition 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 2
• 230000000747 cardiac effect Effects 0.000 description 2
• 235000010418 carrageenan Nutrition 0.000 description 2
• 229920001525 carrageenan Polymers 0.000 description 2
• 239000000679 carrageenan Substances 0.000 description 2
• 229940113118 carrageenan Drugs 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 229940043431 ceratonia Drugs 0.000 description 2
• 229940045110 chitosan Drugs 0.000 description 2
• 238000011260 co-administration Methods 0.000 description 2
• 230000015271 coagulation Effects 0.000 description 2
• 238000005345 coagulation Methods 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 239000002299 complementary DNA Substances 0.000 description 2
• 238000012937 correction Methods 0.000 description 2
• 239000002178 crystalline material Substances 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000008025 crystallization Effects 0.000 description 2
• 229960000684 cytarabine Drugs 0.000 description 2
• 229940059359 dacogen Drugs 0.000 description 2
• 238000013480 data collection Methods 0.000 description 2
• 230000007812 deficiency Effects 0.000 description 2
• 230000035487 diastolic blood pressure Effects 0.000 description 2
• 235000005911 diet Nutrition 0.000 description 2
• 230000037213 diet Effects 0.000 description 2
• 235000014113 dietary fatty acids Nutrition 0.000 description 2
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
• 238000007907 direct compression Methods 0.000 description 2
• 208000009190 disseminated intravascular coagulation Diseases 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 229940001018 emtriva Drugs 0.000 description 2
• 239000003995 emulsifying agent Substances 0.000 description 2
• 238000003366 endpoint assay Methods 0.000 description 2
• 230000010437 erythropoiesis Effects 0.000 description 2
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 2
• MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 2
• 229960004667 ethyl cellulose Drugs 0.000 description 2
• 230000007717 exclusion Effects 0.000 description 2
• 230000029142 excretion Effects 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 238000011985 exploratory data analysis Methods 0.000 description 2
• 239000000194 fatty acid Substances 0.000 description 2
• 229930195729 fatty acid Natural products 0.000 description 2
• 150000004665 fatty acids Chemical class 0.000 description 2
• NMUSYJAQQFHJEW-ARQDHWQXSA-N fazarabine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-ARQDHWQXSA-N 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
• 230000037406 food intake Effects 0.000 description 2
• 239000012737 fresh medium Substances 0.000 description 2
• 125000000524 functional group Chemical group 0.000 description 2
• 230000002538 fungal effect Effects 0.000 description 2
• 208000001288 gastroparesis Diseases 0.000 description 2
• 229960005277 gemcitabine Drugs 0.000 description 2
• 230000024924 glomerular filtration Effects 0.000 description 2
• 125000005456 glyceride group Chemical group 0.000 description 2
• 235000011187 glycerol Nutrition 0.000 description 2
• 229940049654 glyceryl behenate Drugs 0.000 description 2
• FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 description 2
• 229940046813 glyceryl palmitostearate Drugs 0.000 description 2
• 230000003394 haemopoietic effect Effects 0.000 description 2
• 208000019622 heart disease Diseases 0.000 description 2
• 238000011134 hematopoietic stem cell transplantation Methods 0.000 description 2
• 239000000710 homodimer Substances 0.000 description 2
• 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
• 230000036571 hydration Effects 0.000 description 2
• 238000006703 hydration reaction Methods 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 230000003301 hydrolyzing effect Effects 0.000 description 2
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
• 229940071676 hydroxypropylcellulose Drugs 0.000 description 2
• 230000009610 hypersensitivity Effects 0.000 description 2
• 230000007954 hypoxia Effects 0.000 description 2
• 229960003943 hypromellose Drugs 0.000 description 2
• 101150046722 idh1 gene Proteins 0.000 description 2
• 239000007943 implant Substances 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• 206010024378 leukocytosis Diseases 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
• 239000001095 magnesium carbonate Substances 0.000 description 2
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
• 235000014380 magnesium carbonate Nutrition 0.000 description 2
• 239000000395 magnesium oxide Substances 0.000 description 2
• CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
• 235000012245 magnesium oxide Nutrition 0.000 description 2
• AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 229960002160 maltose Drugs 0.000 description 2
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 230000004060 metabolic process Effects 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 239000002480 mineral oil Substances 0.000 description 2
• 235000010446 mineral oil Nutrition 0.000 description 2
• 230000002438 mitochondrial effect Effects 0.000 description 2
• 235000019796 monopotassium phosphate Nutrition 0.000 description 2
• 238000002552 multiple reaction monitoring Methods 0.000 description 2
• 208000010125 myocardial infarction Diseases 0.000 description 2
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
• 239000000346 nonvolatile oil Substances 0.000 description 2
• 239000002773 nucleotide Substances 0.000 description 2
• 125000003729 nucleotide group Chemical group 0.000 description 2
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
• 239000004006 olive oil Substances 0.000 description 2
• 235000008390 olive oil Nutrition 0.000 description 2
• 239000007935 oral tablet Substances 0.000 description 2
• 150000002891 organic anions Chemical class 0.000 description 2
• 239000012044 organic layer Substances 0.000 description 2
• 238000005895 oxidative decarboxylation reaction Methods 0.000 description 2
• 230000003285 pharmacodynamic effect Effects 0.000 description 2
• 229960002036 phenytoin Drugs 0.000 description 2
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
• 239000006187 pill Substances 0.000 description 2
• 239000004014 plasticizer Substances 0.000 description 2
• 229960000502 poloxamer Drugs 0.000 description 2
• 229920001983 poloxamer Polymers 0.000 description 2
• 235000013856 polydextrose Nutrition 0.000 description 2
• 239000001259 polydextrose Substances 0.000 description 2
• 229940035035 polydextrose Drugs 0.000 description 2
• 229920000193 polymethacrylate Polymers 0.000 description 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
• 229920001451 polypropylene glycol Polymers 0.000 description 2
• 229920000136 polysorbate Polymers 0.000 description 2
• 229920000053 polysorbate 80 Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 235000007686 potassium Nutrition 0.000 description 2
• 208000024896 potassium deficiency disease Diseases 0.000 description 2
• 229940069328 povidone Drugs 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 108090000765 processed proteins & peptides Proteins 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 239000000583 progesterone congener Substances 0.000 description 2
• 208000037821 progressive disease Diseases 0.000 description 2
• 229940096913 pseudoisocytidine Drugs 0.000 description 2
• 208000020016 psychiatric disease Diseases 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 229930002330 retinoic acid Natural products 0.000 description 2
• BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 description 2
• 229960000672 rosuvastatin Drugs 0.000 description 2
• 102220197847 rs121913502 Human genes 0.000 description 2
• 102220197849 rs267606870 Human genes 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 238000011452 sequencing regimen Methods 0.000 description 2
• 230000035939 shock Effects 0.000 description 2
• 208000020352 skin basal cell carcinoma Diseases 0.000 description 2
• 201000010106 skin squamous cell carcinoma Diseases 0.000 description 2
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
• 229920003109 sodium starch glycolate Polymers 0.000 description 2
• 239000008109 sodium starch glycolate Substances 0.000 description 2
• 229940079832 sodium starch glycolate Drugs 0.000 description 2
• 229940045902 sodium stearyl fumarate Drugs 0.000 description 2
• 239000000934 spermatocidal agent Substances 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 238000012109 statistical procedure Methods 0.000 description 2
• 239000008117 stearic acid Substances 0.000 description 2
• 208000011580 syndromic disease Diseases 0.000 description 2
• 230000035488 systolic blood pressure Effects 0.000 description 2
• 229960000278 theophylline Drugs 0.000 description 2
• 229960002784 thioridazine Drugs 0.000 description 2
• XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 2
• 229960000488 tizanidine Drugs 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 229940074410 trehalose Drugs 0.000 description 2
• 231100000402 unacceptable toxicity Toxicity 0.000 description 2
• 210000002438 upper gastrointestinal tract Anatomy 0.000 description 2
• 238000002562 urinalysis Methods 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 230000002861 ventricular Effects 0.000 description 2
• 238000012800 visualization Methods 0.000 description 2
• 239000000811 xylitol Substances 0.000 description 2
• 235000010447 xylitol Nutrition 0.000 description 2
• 229960002675 xylitol Drugs 0.000 description 2
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
• DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
• OSIPHTAXRZMCDG-UHFFFAOYSA-N 1,1-bis(methylamino)ethanol Chemical compound CNC(C)(O)NC OSIPHTAXRZMCDG-UHFFFAOYSA-N 0.000 description 1
• SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
• TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
• KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical class CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 1
• HQHQCEKUGWOYPS-UHFFFAOYSA-N 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(octadecylamino)pyrimidin-2-one Chemical compound O=C1N=C(NCCCCCCCCCCCCCCCCCC)C=CN1C1C(O)C(O)C(CO)O1 HQHQCEKUGWOYPS-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 1
• LYNBZRJTRHTSKI-UHFFFAOYSA-N 2-(trifluoromethyl)pyridin-4-amine Chemical compound NC1=CC=NC(C(F)(F)F)=C1 LYNBZRJTRHTSKI-UHFFFAOYSA-N 0.000 description 1
• ATRQECRSCHYSNP-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=CC=N1 ATRQECRSCHYSNP-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 description 1
• 229940080296 2-naphthalenesulfonate Drugs 0.000 description 1
• LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• ZRPLANDPDWYOMZ-UHFFFAOYSA-N 3-cyclopentylpropionic acid Chemical compound OC(=O)CCC1CCCC1 ZRPLANDPDWYOMZ-UHFFFAOYSA-N 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-M 3-phenylpropionate Chemical compound [O-]C(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-M 0.000 description 1
• WZPHDUJLRGIZEX-UHFFFAOYSA-N 4-chloro-1-[2-(trifluoromethyl)pyridin-4-yl]-6-[6-(trifluoromethyl)pyridin-2-yl]-2H-1,3,5-triazine Chemical compound ClC1=NCN(C(=N1)C1=NC(=CC=C1)C(F)(F)F)C1=CC(=NC=C1)C(F)(F)F WZPHDUJLRGIZEX-UHFFFAOYSA-N 0.000 description 1
• NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 description 1
• OZQDLJNDRVBCST-SHUUEZRQSA-N 5-amino-2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazin-3-one Chemical compound O=C1N=C(N)C=NN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 OZQDLJNDRVBCST-SHUUEZRQSA-N 0.000 description 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 229920000945 Amylopectin Polymers 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 101150076489 B gene Proteins 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
• URUBZXVIOILFLM-UHFFFAOYSA-N CC(C)(CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)OS(C)(=O)=O Chemical compound CC(C)(CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)OS(C)(=O)=O URUBZXVIOILFLM-UHFFFAOYSA-N 0.000 description 1
• 101100342337 Caenorhabditis elegans klf-1 gene Proteins 0.000 description 1
• 101100396617 Candida albicans (strain SC5314 / ATCC MYA-2876) IHD1 gene Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 1
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
• 208000009458 Carcinoma in Situ Diseases 0.000 description 1
• 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
• 206010050337 Cerumen impaction Diseases 0.000 description 1
• 206010061809 Cervix carcinoma stage 0 Diseases 0.000 description 1
• 241000723346 Cinnamomum camphora Species 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 241000938605 Crocodylia Species 0.000 description 1
• 229920002785 Croscarmellose sodium Polymers 0.000 description 1
• 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 1
• 102100021704 Cytochrome P450 2D6 Human genes 0.000 description 1
• 201000006762 D-2-hydroxyglutaric aciduria Diseases 0.000 description 1
• 230000026641 DNA hypermethylation Effects 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• FLFGNMFWNBOBGE-FNNZEKJRSA-N Elacytarabine Chemical compound O[C@H]1[C@H](O)[C@@H](COC(=O)CCCCCCC/C=C/CCCCCCCC)O[C@H]1N1C(=O)N=C(N)C=C1 FLFGNMFWNBOBGE-FNNZEKJRSA-N 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• 239000004386 Erythritol Substances 0.000 description 1
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
• 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 1
• 208000036566 Erythroleukaemia Diseases 0.000 description 1
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
• 229920003134 Eudragit® polymer Polymers 0.000 description 1
• 239000001263 FEMA 3042 Substances 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 108010044495 Fetal Hemoglobin Proteins 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 108010085682 Hemoglobin A Proteins 0.000 description 1
• 102000007513 Hemoglobin A Human genes 0.000 description 1
• 101100452039 Homo sapiens IDH2 gene Proteins 0.000 description 1
• 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 description 1
• 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
• 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
• OUBORTRIKPEZMG-UHFFFAOYSA-N INT-2 Chemical compound Nc1c(ncn1-c1ccc(F)cc1)C(=N)C#N OUBORTRIKPEZMG-UHFFFAOYSA-N 0.000 description 1
• 206010062717 Increased upper airway secretion Diseases 0.000 description 1
• 229920001202 Inulin Polymers 0.000 description 1
• 101710175291 Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 description 1
• 108010044467 Isoenzymes Proteins 0.000 description 1
• 102100020920 L-2-hydroxyglutarate dehydrogenase, mitochondrial Human genes 0.000 description 1
• QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
• 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• 208000034800 Leukoencephalopathies Diseases 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 210000002361 Megakaryocyte Progenitor Cell Anatomy 0.000 description 1
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
• 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 description 1
• UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 1
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
• 229910002651 NO3 Inorganic materials 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
• 235000021314 Palmitic acid Nutrition 0.000 description 1
• 206010033661 Pancytopenia Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
• 239000004264 Petrolatum Substances 0.000 description 1
• 229920002319 Poly(methyl acrylate) Polymers 0.000 description 1
• 229920000148 Polycarbophil calcium Polymers 0.000 description 1
• 229920001214 Polysorbate 60 Polymers 0.000 description 1
• 208000006994 Precancerous Conditions Diseases 0.000 description 1
• 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
• 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 102000012751 Pyruvate Dehydrogenase Complex Human genes 0.000 description 1
• 108010090051 Pyruvate Dehydrogenase Complex Proteins 0.000 description 1
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
• 238000002070 Raman circular dichroism spectroscopy Methods 0.000 description 1
• 208000034432 Refractory anemia with excess blasts type 2 Diseases 0.000 description 1
• 208000007660 Residual Neoplasm Diseases 0.000 description 1
• 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
• 229940124639 Selective inhibitor Drugs 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 240000006474 Theobroma bicolor Species 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 108090000340 Transaminases Proteins 0.000 description 1
• 102000003929 Transaminases Human genes 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 101001060278 Xenopus laevis Fibroblast growth factor 3 Proteins 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 229920002494 Zein Polymers 0.000 description 1
• WGCOQYDRMPFAMN-ZDUSSCGKSA-N [(3S)-3-[4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxypiperidin-1-yl]-pyrimidin-5-ylmethanone Chemical compound NCC1=CC(=NC(=C1)C(F)(F)F)O[C@@H]1CN(CCC1)C(=O)C=1C=NC=NC=1 WGCOQYDRMPFAMN-ZDUSSCGKSA-N 0.000 description 1
• 229940124532 absorption promoter Drugs 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical group OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 description 1
• ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
• WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
• 239000012346 acetyl chloride Substances 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 208000021841 acute erythroid leukemia Diseases 0.000 description 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 235000010419 agar Nutrition 0.000 description 1
• 229940050528 albumin Drugs 0.000 description 1
• 229940072056 alginate Drugs 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 229910001413 alkali metal ion Inorganic materials 0.000 description 1
• HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 235000010210 aluminium Nutrition 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
• 210000004381 amniotic fluid Anatomy 0.000 description 1
• BBDAGFIXKZCXAH-CCXZUQQUSA-N ancitabine Chemical compound N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 BBDAGFIXKZCXAH-CCXZUQQUSA-N 0.000 description 1
• 150000001449 anionic compounds Chemical class 0.000 description 1
• 239000012296 anti-solvent Substances 0.000 description 1
• 210000001742 aqueous humor Anatomy 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 210000000270 basal cell Anatomy 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 235000013871 bee wax Nutrition 0.000 description 1
• 239000012166 beeswax Substances 0.000 description 1
• 239000000440 bentonite Substances 0.000 description 1
• 229910000278 bentonite Inorganic materials 0.000 description 1
• 229940092782 bentonite Drugs 0.000 description 1
• 235000012216 bentonite Nutrition 0.000 description 1
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
• 229940077388 benzenesulfonate Drugs 0.000 description 1
• 229940050390 benzoate Drugs 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• 229960004217 benzyl alcohol Drugs 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 239000000090 biomarker Substances 0.000 description 1
• OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 238000004820 blood count Methods 0.000 description 1
• 229910021538 borax Inorganic materials 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
• 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
• XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 239000000378 calcium silicate Substances 0.000 description 1
• 229910052918 calcium silicate Inorganic materials 0.000 description 1
• 235000012241 calcium silicate Nutrition 0.000 description 1
• OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
• 229960000846 camphor Drugs 0.000 description 1
• 229930008380 camphor Natural products 0.000 description 1
• MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
• 239000012830 cancer therapeutic Substances 0.000 description 1
• 229960004117 capecitabine Drugs 0.000 description 1
• 239000007963 capsule composition Substances 0.000 description 1
• 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 229960001631 carbomer Drugs 0.000 description 1
• 235000011089 carbon dioxide Nutrition 0.000 description 1
• 150000007942 carboxylates Chemical class 0.000 description 1
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
• 239000012876 carrier material Substances 0.000 description 1
• 239000004359 castor oil Substances 0.000 description 1
• 235000019438 castor oil Nutrition 0.000 description 1
• 150000001767 cationic compounds Chemical class 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 210000002939 cerumen Anatomy 0.000 description 1
• 210000003756 cervix mucus Anatomy 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 229940081733 cetearyl alcohol Drugs 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 210000004913 chyme Anatomy 0.000 description 1
• 238000005352 clarification Methods 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 239000008119 colloidal silica Substances 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 238000009108 consolidation therapy Methods 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 229920001531 copovidone Polymers 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 229940099112 cornstarch Drugs 0.000 description 1
• 235000012343 cottonseed oil Nutrition 0.000 description 1
• 239000002385 cottonseed oil Substances 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 229960001681 croscarmellose sodium Drugs 0.000 description 1
• 229960000913 crospovidone Drugs 0.000 description 1
• 229920006037 cross link polymer Polymers 0.000 description 1
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
• 208000024389 cytopenia Diseases 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 229960002887 deanol Drugs 0.000 description 1
• 238000000354 decomposition reaction Methods 0.000 description 1
• 229910052805 deuterium Inorganic materials 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 229940043237 diethanolamine Drugs 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 150000004683 dihydrates Chemical class 0.000 description 1
• 230000000916 dilatatory effect Effects 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
• AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 229960000878 docusate sodium Drugs 0.000 description 1
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
• 229940043264 dodecyl sulfate Drugs 0.000 description 1
• 239000000890 drug combination Substances 0.000 description 1
• 238000007908 dry granulation Methods 0.000 description 1
• 229940048820 edetates Drugs 0.000 description 1
• 230000002900 effect on cell Effects 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 238000000132 electrospray ionisation Methods 0.000 description 1
• 239000008387 emulsifying waxe Substances 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 229940095399 enema Drugs 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 238000009505 enteric coating Methods 0.000 description 1
• 239000002702 enteric coating Substances 0.000 description 1
• 230000001973 epigenetic effect Effects 0.000 description 1
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
• 235000019414 erythritol Nutrition 0.000 description 1
• 229940009714 erythritol Drugs 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 229940093476 ethylene glycol Drugs 0.000 description 1
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 210000003722 extracellular fluid Anatomy 0.000 description 1
• 229950005096 fazarabine Drugs 0.000 description 1
• 210000003754 fetus Anatomy 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
• 230000004907 flux Effects 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229960001031 glucose Drugs 0.000 description 1
• JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
• 229960002449 glycine Drugs 0.000 description 1
• 239000003979 granulating agent Substances 0.000 description 1
• 238000005469 granulation Methods 0.000 description 1
• 230000003179 granulation Effects 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 150000003278 haem Chemical class 0.000 description 1
• 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 description 1
• MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
• 125000001072 heteroaryl group Chemical group 0.000 description 1
• 239000000833 heterodimer Substances 0.000 description 1
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
• 230000002962 histologic effect Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 108010036396 human isocitrate dehydrogenase 2 Proteins 0.000 description 1
• 102000012084 human isocitrate dehydrogenase 2 Human genes 0.000 description 1
• 235000020256 human milk Nutrition 0.000 description 1
• 210000004251 human milk Anatomy 0.000 description 1
• BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
• 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
• 239000001341 hydroxy propyl starch Substances 0.000 description 1
• 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 238000005470 impregnation Methods 0.000 description 1
• 201000004933 in situ carcinoma Diseases 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 231100000546 inhibition of ovulation Toxicity 0.000 description 1
• 229940102223 injectable solution Drugs 0.000 description 1
• 229940102213 injectable suspension Drugs 0.000 description 1
• 229910001412 inorganic anion Inorganic materials 0.000 description 1
• 229910001411 inorganic cation Inorganic materials 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000007919 intrasynovial administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 229940029339 inulin Drugs 0.000 description 1
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
• 229960004903 invert sugar Drugs 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• 239000000905 isomalt Substances 0.000 description 1
• 235000010439 isomalt Nutrition 0.000 description 1
• HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• WIJZXSAJMHAVGX-DHLKQENFSA-N ivosidenib Chemical compound FC1=CN=CC(N([C@H](C(=O)NC2CC(F)(F)C2)C=2C(=CC=CC=2)Cl)C(=O)[C@H]2N(C(=O)CC2)C=2N=CC=C(C=2)C#N)=C1 WIJZXSAJMHAVGX-DHLKQENFSA-N 0.000 description 1
• 208000017169 kidney disease Diseases 0.000 description 1
• VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
• 235000019388 lanolin Nutrition 0.000 description 1
• 101150095787 ldh2 gene Proteins 0.000 description 1
• 101150100271 ldhb gene Proteins 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 239000006210 lotion Substances 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 239000008176 lyophilized powder Substances 0.000 description 1
• 229960001708 magnesium carbonate Drugs 0.000 description 1
• 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
• 229960000869 magnesium oxide Drugs 0.000 description 1
• 229910052919 magnesium silicate Inorganic materials 0.000 description 1
• 235000019792 magnesium silicate Nutrition 0.000 description 1
• 229960002366 magnesium silicate Drugs 0.000 description 1
• 229940057948 magnesium stearate Drugs 0.000 description 1
• HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
• 238000002826 magnetic-activated cell sorting Methods 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 229960001855 mannitol Drugs 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 229940057917 medium chain triglycerides Drugs 0.000 description 1
• 229960003194 meglumine Drugs 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 description 1
• 229940042472 mineral oil Drugs 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 210000003470 mitochondria Anatomy 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 229940111688 monobasic potassium phosphate Drugs 0.000 description 1
• 150000004682 monohydrates Chemical class 0.000 description 1
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
• 210000003097 mucus Anatomy 0.000 description 1
• 208000012847 myelodysplastic syndrome with excess blasts-2 Diseases 0.000 description 1
• 201000000050 myeloid neoplasm Diseases 0.000 description 1
• 239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 description 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
• GTWJETSWSUWSEJ-UHFFFAOYSA-N n-benzylaniline Chemical compound C=1C=CC=CC=1CNC1=CC=CC=C1 GTWJETSWSUWSEJ-UHFFFAOYSA-N 0.000 description 1
• GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
• 229940097496 nasal spray Drugs 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 208000004235 neutropenia Diseases 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
• 231100000344 non-irritating Toxicity 0.000 description 1
• 238000010899 nucleation Methods 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 239000003605 opacifier Substances 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000001590 oxidative effect Effects 0.000 description 1
• 229940098695 palmitic acid Drugs 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 238000005453 pelletization Methods 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 230000035699 permeability Effects 0.000 description 1
• JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
• 229940066842 petrolatum Drugs 0.000 description 1
• 235000019271 petrolatum Nutrition 0.000 description 1
• 239000003208 petroleum Substances 0.000 description 1
• 229940124531 pharmaceutical excipient Drugs 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
• WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
• 208000026435 phlegm Diseases 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
• UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
• 229940075930 picrate Drugs 0.000 description 1
• OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
• IUGYQRQAERSCNH-UHFFFAOYSA-M pivalate Chemical compound CC(C)(C)C([O-])=O IUGYQRQAERSCNH-UHFFFAOYSA-M 0.000 description 1
• 229950010765 pivalate Drugs 0.000 description 1
• 210000004910 pleural fluid Anatomy 0.000 description 1
• 229960005455 polacrilin Drugs 0.000 description 1
• 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 229950005134 polycarbophil Drugs 0.000 description 1
• 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
• 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
• 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 229940113124 polysorbate 60 Drugs 0.000 description 1
• 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
• 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
• 239000011148 porous material Substances 0.000 description 1
• ZDHURYWHEBEGHO-UHFFFAOYSA-N potassiopotassium Chemical compound [K].[K] ZDHURYWHEBEGHO-UHFFFAOYSA-N 0.000 description 1
• 229960003975 potassium Drugs 0.000 description 1
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
• 235000010235 potassium benzoate Nutrition 0.000 description 1
• 239000004300 potassium benzoate Substances 0.000 description 1
• 229940103091 potassium benzoate Drugs 0.000 description 1
• 239000001103 potassium chloride Substances 0.000 description 1
• 235000011164 potassium chloride Nutrition 0.000 description 1
• GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 210000004909 pre-ejaculatory fluid Anatomy 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
• 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
• 235000010388 propyl gallate Nutrition 0.000 description 1
• 239000000473 propyl gallate Substances 0.000 description 1
• 229940075579 propyl gallate Drugs 0.000 description 1
• 235000013772 propylene glycol Nutrition 0.000 description 1
• 229950008679 protamine sulfate Drugs 0.000 description 1
• 238000010926 purge Methods 0.000 description 1
• 210000004915 pus Anatomy 0.000 description 1
• 125000001453 quaternary ammonium group Chemical group 0.000 description 1
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 229940100618 rectal suppository Drugs 0.000 description 1
• 239000006215 rectal suppository Substances 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 238000005057 refrigeration Methods 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
• 238000011069 regeneration method Methods 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
• YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
• 229960001860 salicylate Drugs 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 210000002374 sebum Anatomy 0.000 description 1
• 238000010187 selection method Methods 0.000 description 1
• 210000000582 semen Anatomy 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 235000012239 silicon dioxide Nutrition 0.000 description 1
• 229960001866 silicon dioxide Drugs 0.000 description 1
• 229940083037 simethicone Drugs 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 229910052938 sodium sulfate Inorganic materials 0.000 description 1
• 235000011152 sodium sulphate Nutrition 0.000 description 1
• 235000010339 sodium tetraborate Nutrition 0.000 description 1
• OTNVGWMVOULBFZ-UHFFFAOYSA-N sodium;hydrochloride Chemical compound [Na].Cl OTNVGWMVOULBFZ-UHFFFAOYSA-N 0.000 description 1
• 239000008279 sol Substances 0.000 description 1
• 239000007909 solid dosage form Substances 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 229940075554 sorbate Drugs 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 235000011076 sorbitan monostearate Nutrition 0.000 description 1
• 239000001587 sorbitan monostearate Substances 0.000 description 1
• 229940035048 sorbitan monostearate Drugs 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000010421 standard material Substances 0.000 description 1
• 229960004274 stearic acid Drugs 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 210000004243 sweat Anatomy 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 235000015523 tannic acid Nutrition 0.000 description 1
• 229920002258 tannic acid Polymers 0.000 description 1
• LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
• 229940033123 tannic acid Drugs 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 101150003389 tdh2 gene Proteins 0.000 description 1
• 210000001138 tear Anatomy 0.000 description 1
• TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
• 208000019112 therapy-related myeloid neoplasm Diseases 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 206010043554 thrombocytopenia Diseases 0.000 description 1
• 210000001519 tissue Anatomy 0.000 description 1
• 229960001295 tocopherol Drugs 0.000 description 1
• 239000011732 tocopherol Substances 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 230000005945 translocation Effects 0.000 description 1
• IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
• 150000004684 trihydrates Chemical class 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 229960000281 trometamol Drugs 0.000 description 1
• 238000009810 tubal ligation Methods 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical class CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
• 206010046901 vaginal discharge Diseases 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 210000004916 vomit Anatomy 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 238000005550 wet granulation Methods 0.000 description 1
• 229940045860 white wax Drugs 0.000 description 1
• 229920001285 xanthan gum Polymers 0.000 description 1
• 235000010493 xanthan gum Nutrition 0.000 description 1
• 239000000230 xanthan gum Substances 0.000 description 1
• 229940082509 xanthan gum Drugs 0.000 description 1
• 229940093612 zein Drugs 0.000 description 1
• 239000005019 zein Substances 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1
• 239000004246 zinc acetate Substances 0.000 description 1
• XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1