CA3002029A1 - Combination therapy for treating malignancies - Google Patents
Combination therapy for treating malignancies Download PDFInfo
- Publication number
- CA3002029A1 CA3002029A1 CA3002029A CA3002029A CA3002029A1 CA 3002029 A1 CA3002029 A1 CA 3002029A1 CA 3002029 A CA3002029 A CA 3002029A CA 3002029 A CA3002029 A CA 3002029A CA 3002029 A1 CA3002029 A1 CA 3002029A1
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- azacitidine
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PL2307002T3 (pl) * | 2008-06-09 | 2013-05-31 | Cyclacel Ltd | Kombinacje sapacytabiny lub cndac z inhibitorami metylotransferazy dna, takimi jak decytabina i prokaina |
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ， インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| CA2793836C (en) * | 2009-10-21 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| JP6231988B2 (ja) * | 2011-11-03 | 2017-11-15 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎｅｄｄ８活性化酵素阻害剤および低メチル化剤の投与 |
| KR101893112B1 (ko) | 2012-01-06 | 2018-08-30 | 아지오스 파마슈티컬스 아이엔씨. | 치료학적으로 활성인 화합물 및 이의 이용 방법 |
| PE20160744A1 (es) * | 2013-07-11 | 2016-08-01 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer |
| TWI666208B (zh) | 2013-08-02 | 2019-07-21 | 美商阿吉斯藥品有限公司 | 治療活性化合物及其使用方法（三） |
| WO2015018060A1 (en) | 2013-08-09 | 2015-02-12 | Agios Pharmaceuticals, Inc. | Crystalline forms of therapeutically active compounds and use thereof |
| KR20170057411A (ko) | 2014-09-29 | 2017-05-24 | 아지오스 파마슈티컬스 아이엔씨. | 치료적 활성 화합물 및 이들의 사용 방법 |
| WO2016126798A1 (en) | 2015-02-04 | 2016-08-11 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3331866B1 (en) | 2015-08-05 | 2023-07-26 | Les Laboratoires Servier | Methods of preparing a 6-heteroaryl-1,3,5-triazine-2,4-diol and a 6-heteroaryl-1,3,5-triazine-2,4-diamine |
| IL311873A (en) | 2015-10-15 | 2024-06-01 | Agios Pharmaceuticals Inc | Combination therapy for treating malignancies |
| CA3007363A1 (en) | 2015-12-04 | 2017-06-08 | Agios Pharmaceuticals, Inc. | Methods of treatment of malignancies |
| US10137130B2 (en) | 2016-02-26 | 2018-11-27 | Celgene Corporation | Methods of treatment of malignancies |
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| MX2018004599A (es) | 2018-09-21 |
| US10695352B2 (en) | 2020-06-30 |
| BR112018007447B1 (pt) | 2023-12-05 |
| EP3362070B1 (en) | 2021-01-27 |
| IL258580A (en) | 2018-05-31 |
| SG11201802964QA (en) | 2018-05-30 |
| ZA201802420B (en) | 2020-08-26 |
| JP2018535951A (ja) | 2018-12-06 |
| US20180303840A1 (en) | 2018-10-25 |
| CL2018000955A1 (es) | 2018-09-14 |
| EA036129B1 (ru) | 2020-10-01 |
| AU2016340098A1 (en) | 2018-05-10 |
| JP6895956B2 (ja) | 2021-06-30 |
| EA201890961A1 (ru) | 2018-11-30 |
| CN108601787A (zh) | 2018-09-28 |
| BR112018007447A2 (en) | 2018-10-23 |
| US20210100805A1 (en) | 2021-04-08 |
| ES2862730T3 (es) | 2021-10-07 |
| EP3362070A1 (en) | 2018-08-22 |
| SG10201912869WA (en) | 2020-02-27 |
| KR102701893B1 (ko) | 2024-09-03 |
| CN108601787B (zh) | 2022-07-29 |
| WO2017066611A1 (en) | 2017-04-20 |
| NZ741433A (en) | 2024-07-26 |
| IL258580B (en) | 2021-05-31 |
| KR20180064529A (ko) | 2018-06-14 |
| AU2016340098B2 (en) | 2022-06-02 |
| MX381582B (es) | 2025-03-12 |
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