ES2847169T3 - Tratamiento de migraña con acetil-leucina - Google Patents

Tratamiento de migraña con acetil-leucina Download PDF

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Publication number
ES2847169T3
ES2847169T3 ES18749124T ES18749124T ES2847169T3 ES 2847169 T3 ES2847169 T3 ES 2847169T3 ES 18749124 T ES18749124 T ES 18749124T ES 18749124 T ES18749124 T ES 18749124T ES 2847169 T3 ES2847169 T3 ES 2847169T3
Authority
ES
Spain
Prior art keywords
leucine
acetyl
pharmaceutically acceptable
migraine
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18749124T
Other languages
English (en)
Spanish (es)
Inventor
Michael Strupp
Mallory Factor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intrabio Ltd
Original Assignee
Intrabio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59358204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2847169(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intrabio Ltd filed Critical Intrabio Ltd
Application granted granted Critical
Publication of ES2847169T3 publication Critical patent/ES2847169T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES18749124T 2017-06-14 2018-06-25 Tratamiento de migraña con acetil-leucina Active ES2847169T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709459.0A GB201709459D0 (en) 2017-06-14 2017-06-14 Treatment for migraine
PCT/IB2018/054676 WO2018229738A1 (en) 2017-06-14 2018-06-25 Treatment for migraine

Publications (1)

Publication Number Publication Date
ES2847169T3 true ES2847169T3 (es) 2021-08-02

Family

ID=59358204

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18749124T Active ES2847169T3 (es) 2017-06-14 2018-06-25 Tratamiento de migraña con acetil-leucina

Country Status (25)

Country Link
US (1) US11471434B2 (enExample)
EP (1) EP3638370B1 (enExample)
JP (1) JP7130739B2 (enExample)
KR (1) KR102594130B1 (enExample)
CN (1) CN111093772B (enExample)
AU (1) AU2018284330B2 (enExample)
CY (1) CY1123860T1 (enExample)
DK (1) DK3638370T3 (enExample)
ES (1) ES2847169T3 (enExample)
GB (1) GB201709459D0 (enExample)
HR (1) HRP20210108T1 (enExample)
HU (1) HUE053089T2 (enExample)
IL (1) IL271211B2 (enExample)
LT (1) LT3638370T (enExample)
MA (1) MA49396B1 (enExample)
MD (1) MD3638370T2 (enExample)
MX (1) MX387909B (enExample)
PL (1) PL3638370T3 (enExample)
PT (1) PT3638370T (enExample)
RS (1) RS61481B1 (enExample)
SG (1) SG11201912146RA (enExample)
SI (1) SI3638370T1 (enExample)
SM (1) SMT202100037T1 (enExample)
WO (1) WO2018229738A1 (enExample)
ZA (1) ZA201908087B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3091353A1 (en) * 2018-02-15 2019-08-22 Intrabio Ltd Therapeutic agents for treating restless legs syndrome
BR112021010923A2 (pt) 2018-12-06 2021-08-24 Intrabio Ltd Análogos deuterados de acetileucina

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701662L (sv) * 1987-04-22 1988-10-23 Gelder Nico M Van Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
US20060063827A1 (en) 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
MY142655A (en) * 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
SI1641775T1 (sl) * 2003-07-03 2009-08-31 Euro Celtique Sa 2-piridin alkinski derivati, uporabni za zdravljenje bolečine
EP2080757A1 (en) * 2003-07-24 2009-07-22 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
DE602004017481D1 (de) * 2003-09-22 2008-12-11 Euro Celtique Sa Zur behandlung von schmerzen geeignete therapeutische mittel
PT2017276E (pt) * 2003-09-22 2011-04-05 Euro Celtique Sa Compostos de fenilcarboxamida úteis para o tratamento da dor
CN1902178A (zh) * 2003-12-30 2007-01-24 欧洲凯尔特公司 用于治疗疼痛的哌嗪
FR2905600B1 (fr) * 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
TN2010000251A1 (fr) 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
JP5876423B2 (ja) * 2010-06-22 2016-03-02 塩野義製薬株式会社 Ｔｒｐｖ１阻害活性を有する化合物とその使用
EP2588130B1 (en) 2010-06-25 2016-08-17 Shire Human Genetic Therapies, Inc. Cns delivery of therapeutic agents
EP3536368B1 (en) * 2010-11-09 2025-09-17 MannKind Corporation Dry powder inhaler comprising a serotonin receptor agonist and a diketopiperazine for treating migraines
AU2012293417A1 (en) * 2011-08-10 2013-05-02 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
WO2017182802A1 (en) 2016-04-19 2017-10-26 Intrabio Ltd Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function
KR102467953B1 (ko) 2016-08-11 2022-11-16 인트라바이오 리미티드 리소좀 축적 질환과 관련된 약제 조성물 및 용도
MA43828B1 (fr) 2016-08-11 2019-09-30 Intrabio Ltd Agents thérapeutiques pour maladies neurodégénératives
WO2018178670A1 (en) 2017-03-28 2018-10-04 Intrabio Ltd Betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject
MA50399A (fr) 2017-10-18 2020-08-26 Intrabio Ltd Agents thérapeutiques pour mobilité et fonction cognitive améliorées et pour le traitement de maladies neurodégénératives et de troubles de stockage lysosomal
SG11202003390UA (en) 2017-10-18 2020-05-28 Intrabio Ltd Therapeutic agents for neurodegenerative diseases
CA3091353A1 (en) 2018-02-15 2019-08-22 Intrabio Ltd Therapeutic agents for treating restless legs syndrome
BR112021010923A2 (pt) 2018-12-06 2021-08-24 Intrabio Ltd Análogos deuterados de acetileucina
KR20250171484A (ko) 2019-03-02 2025-12-08 인트라바이오 리미티드 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체
US20220362189A1 (en) 2019-06-28 2022-11-17 Intrabio Ltd. Combination therapy with acetyl-leucine and miglustat
WO2021144720A1 (en) 2020-01-13 2021-07-22 Intrabio Ltd Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers

Also Published As

Publication number Publication date
JP2020526575A (ja) 2020-08-31
SI3638370T1 (sl) 2021-04-30
IL271211A (en) 2020-01-30
WO2018229738A1 (en) 2018-12-20
MX2019014784A (es) 2021-11-16
US20200253905A1 (en) 2020-08-13
KR102594130B1 (ko) 2023-10-24
IL271211B1 (en) 2023-09-01
EP3638370A1 (en) 2020-04-22
PT3638370T (pt) 2021-01-26
MA49396A (fr) 2020-04-22
EP3638370B1 (en) 2020-11-11
KR20210013518A (ko) 2021-02-04
HRP20210108T1 (hr) 2021-03-19
US11471434B2 (en) 2022-10-18
CY1123860T1 (el) 2022-05-27
CN111093772A (zh) 2020-05-01
SG11201912146RA (en) 2020-01-30
LT3638370T (lt) 2021-03-25
AU2018284330A1 (en) 2020-01-02
HUE053089T2 (hu) 2021-06-28
DK3638370T3 (da) 2021-01-25
GB201709459D0 (en) 2017-07-26
SMT202100037T1 (it) 2021-03-15
RS61481B1 (sr) 2021-03-31
RU2020100475A (ru) 2021-07-14
CN111093772B (zh) 2023-11-03
IL271211B2 (en) 2024-01-01
ZA201908087B (en) 2024-11-27
CA3067321A1 (en) 2018-12-20
JP7130739B2 (ja) 2022-09-05
RU2020100475A3 (enExample) 2021-10-22
BR112019026660A2 (pt) 2020-07-14
PL3638370T3 (pl) 2021-05-17
MA49396B1 (fr) 2021-03-31
MX387909B (es) 2025-03-19
AU2018284330B2 (en) 2024-03-14
MD3638370T2 (ro) 2021-04-30

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