JP7130739B2 - 片頭痛の治療 - Google Patents

片頭痛の治療 Download PDF

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Publication number
JP7130739B2
JP7130739B2 JP2020519196A JP2020519196A JP7130739B2 JP 7130739 B2 JP7130739 B2 JP 7130739B2 JP 2020519196 A JP2020519196 A JP 2020519196A JP 2020519196 A JP2020519196 A JP 2020519196A JP 7130739 B2 JP7130739 B2 JP 7130739B2
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Japan
Prior art keywords
leucine
migraine
pharmaceutically acceptable
acetyl
acceptable salt
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JP2020519196A
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English (en)
Japanese (ja)
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JP2020526575A (ja
JP2020526575A5 (enExample
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ストルップ マイケル
ファクター マロリー
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イントラビオ エルティーディー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020519196A 2017-06-14 2018-06-25 片頭痛の治療 Active JP7130739B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709459.0A GB201709459D0 (en) 2017-06-14 2017-06-14 Treatment for migraine
PCT/IB2018/054676 WO2018229738A1 (en) 2017-06-14 2018-06-25 Treatment for migraine

Publications (3)

Publication Number Publication Date
JP2020526575A JP2020526575A (ja) 2020-08-31
JP2020526575A5 JP2020526575A5 (enExample) 2021-08-12
JP7130739B2 true JP7130739B2 (ja) 2022-09-05

Family

ID=59358204

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020519196A Active JP7130739B2 (ja) 2017-06-14 2018-06-25 片頭痛の治療

Country Status (25)

Country Link
US (1) US11471434B2 (enExample)
EP (1) EP3638370B1 (enExample)
JP (1) JP7130739B2 (enExample)
KR (1) KR102594130B1 (enExample)
CN (1) CN111093772B (enExample)
AU (1) AU2018284330B2 (enExample)
CY (1) CY1123860T1 (enExample)
DK (1) DK3638370T3 (enExample)
ES (1) ES2847169T3 (enExample)
GB (1) GB201709459D0 (enExample)
HR (1) HRP20210108T1 (enExample)
HU (1) HUE053089T2 (enExample)
IL (1) IL271211B2 (enExample)
LT (1) LT3638370T (enExample)
MA (1) MA49396B1 (enExample)
MD (1) MD3638370T2 (enExample)
MX (1) MX387909B (enExample)
PL (1) PL3638370T3 (enExample)
PT (1) PT3638370T (enExample)
RS (1) RS61481B1 (enExample)
SG (1) SG11201912146RA (enExample)
SI (1) SI3638370T1 (enExample)
SM (1) SMT202100037T1 (enExample)
WO (1) WO2018229738A1 (enExample)
ZA (1) ZA201908087B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3091353A1 (en) * 2018-02-15 2019-08-22 Intrabio Ltd Therapeutic agents for treating restless legs syndrome
BR112021010923A2 (pt) 2018-12-06 2021-08-24 Intrabio Ltd Análogos deuterados de acetileucina

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010503658A (ja) 2006-09-13 2010-02-04 ピエール、ファーブル、メディカマン アセチル−ｌ−ロイシンによるめまいの治療

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701662L (sv) * 1987-04-22 1988-10-23 Gelder Nico M Van Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
US20060063827A1 (en) 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
MY142655A (en) * 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
SI1641775T1 (sl) * 2003-07-03 2009-08-31 Euro Celtique Sa 2-piridin alkinski derivati, uporabni za zdravljenje bolečine
EP2080757A1 (en) * 2003-07-24 2009-07-22 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
DE602004017481D1 (de) * 2003-09-22 2008-12-11 Euro Celtique Sa Zur behandlung von schmerzen geeignete therapeutische mittel
PT2017276E (pt) * 2003-09-22 2011-04-05 Euro Celtique Sa Compostos de fenilcarboxamida úteis para o tratamento da dor
CN1902178A (zh) * 2003-12-30 2007-01-24 欧洲凯尔特公司 用于治疗疼痛的哌嗪
TN2010000251A1 (fr) 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
JP5876423B2 (ja) * 2010-06-22 2016-03-02 塩野義製薬株式会社 Ｔｒｐｖ１阻害活性を有する化合物とその使用
EP2588130B1 (en) 2010-06-25 2016-08-17 Shire Human Genetic Therapies, Inc. Cns delivery of therapeutic agents
EP3536368B1 (en) * 2010-11-09 2025-09-17 MannKind Corporation Dry powder inhaler comprising a serotonin receptor agonist and a diketopiperazine for treating migraines
AU2012293417A1 (en) * 2011-08-10 2013-05-02 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
WO2017182802A1 (en) 2016-04-19 2017-10-26 Intrabio Ltd Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function
KR102467953B1 (ko) 2016-08-11 2022-11-16 인트라바이오 리미티드 리소좀 축적 질환과 관련된 약제 조성물 및 용도
MA43828B1 (fr) 2016-08-11 2019-09-30 Intrabio Ltd Agents thérapeutiques pour maladies neurodégénératives
WO2018178670A1 (en) 2017-03-28 2018-10-04 Intrabio Ltd Betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject
MA50399A (fr) 2017-10-18 2020-08-26 Intrabio Ltd Agents thérapeutiques pour mobilité et fonction cognitive améliorées et pour le traitement de maladies neurodégénératives et de troubles de stockage lysosomal
SG11202003390UA (en) 2017-10-18 2020-05-28 Intrabio Ltd Therapeutic agents for neurodegenerative diseases
CA3091353A1 (en) 2018-02-15 2019-08-22 Intrabio Ltd Therapeutic agents for treating restless legs syndrome
BR112021010923A2 (pt) 2018-12-06 2021-08-24 Intrabio Ltd Análogos deuterados de acetileucina
KR20250171484A (ko) 2019-03-02 2025-12-08 인트라바이오 리미티드 질환을 치료하기 위한 류신, 아세틸 류신, 및 관련된 유사체
US20220362189A1 (en) 2019-06-28 2022-11-17 Intrabio Ltd. Combination therapy with acetyl-leucine and miglustat
WO2021144720A1 (en) 2020-01-13 2021-07-22 Intrabio Ltd Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010503658A (ja) 2006-09-13 2010-02-04 ピエール、ファーブル、メディカマン アセチル−ｌ−ロイシンによるめまいの治療

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Equilibrium Res.，2011年，Vol.70 No.3，pp.172-175
医学のあゆみ，2015年，Vol.255 No.7，pp.757-761

Also Published As

Publication number Publication date
JP2020526575A (ja) 2020-08-31
SI3638370T1 (sl) 2021-04-30
IL271211A (en) 2020-01-30
WO2018229738A1 (en) 2018-12-20
MX2019014784A (es) 2021-11-16
US20200253905A1 (en) 2020-08-13
KR102594130B1 (ko) 2023-10-24
IL271211B1 (en) 2023-09-01
EP3638370A1 (en) 2020-04-22
PT3638370T (pt) 2021-01-26
MA49396A (fr) 2020-04-22
EP3638370B1 (en) 2020-11-11
KR20210013518A (ko) 2021-02-04
HRP20210108T1 (hr) 2021-03-19
US11471434B2 (en) 2022-10-18
CY1123860T1 (el) 2022-05-27
CN111093772A (zh) 2020-05-01
SG11201912146RA (en) 2020-01-30
LT3638370T (lt) 2021-03-25
AU2018284330A1 (en) 2020-01-02
HUE053089T2 (hu) 2021-06-28
DK3638370T3 (da) 2021-01-25
GB201709459D0 (en) 2017-07-26
SMT202100037T1 (it) 2021-03-15
RS61481B1 (sr) 2021-03-31
RU2020100475A (ru) 2021-07-14
CN111093772B (zh) 2023-11-03
IL271211B2 (en) 2024-01-01
ZA201908087B (en) 2024-11-27
CA3067321A1 (en) 2018-12-20
RU2020100475A3 (enExample) 2021-10-22
BR112019026660A2 (pt) 2020-07-14
PL3638370T3 (pl) 2021-05-17
MA49396B1 (fr) 2021-03-31
MX387909B (es) 2025-03-19
ES2847169T3 (es) 2021-08-02
AU2018284330B2 (en) 2024-03-14
MD3638370T2 (ro) 2021-04-30

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