ES2828669T3 - Métodos para genomodificación de linfocitos T alogénicos y altamente activos para inmunoterapia - Google Patents

Métodos para genomodificación de linfocitos T alogénicos y altamente activos para inmunoterapia Download PDF

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Publication number
ES2828669T3
ES2828669T3 ES14727626T ES14727626T ES2828669T3 ES 2828669 T3 ES2828669 T3 ES 2828669T3 ES 14727626 T ES14727626 T ES 14727626T ES 14727626 T ES14727626 T ES 14727626T ES 2828669 T3 ES2828669 T3 ES 2828669T3
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Prior art keywords
tcr
lymphocytes
cells
alpha
beta
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English (en)
Spanish (es)
Inventor
Roman Galetto
Agnes Gouble
Stephanie Grosse
Cécile Schiffer-Mannioui
Laurent Poirot
Andrew Scharenberg
Julianne Smith
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Cellectis SA
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Cellectis SA
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Priority claimed from US13/892,805 external-priority patent/US11603539B2/en
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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ES14727626T 2013-05-13 2014-05-13 Métodos para genomodificación de linfocitos T alogénicos y altamente activos para inmunoterapia Active ES2828669T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/892,805 US11603539B2 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant T cell for immunotherapy
PCT/US2013/040755 WO2013176915A1 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
PCT/US2013/040766 WO2013176916A1 (en) 2012-05-25 2013-05-13 Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
US13/942,191 US20150017136A1 (en) 2013-07-15 2013-07-15 Methods for engineering allogeneic and highly active t cell for immunotherapy
PCT/IB2014/061409 WO2014184741A1 (en) 2013-05-13 2014-05-13 Methods for engineering allogeneic and highly active t cell for immunotheraphy

Publications (1)

Publication Number Publication Date
ES2828669T3 true ES2828669T3 (es) 2021-05-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES14727626T Active ES2828669T3 (es) 2013-05-13 2014-05-13 Métodos para genomodificación de linfocitos T alogénicos y altamente activos para inmunoterapia

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Country Link
US (2) US20150017136A1 (https=)
EP (2) EP2997132B1 (https=)
JP (3) JP6875124B2 (https=)
KR (3) KR102329704B1 (https=)
CN (1) CN105378068A (https=)
AU (1) AU2014266830B2 (https=)
BR (1) BR112015028493A2 (https=)
CA (1) CA2912373A1 (https=)
DK (1) DK2997132T3 (https=)
ES (1) ES2828669T3 (https=)
MX (1) MX380738B (https=)
RU (1) RU2736616C2 (https=)
WO (1) WO2014184741A1 (https=)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6261500B2 (ja) 2011-07-22 2018-01-17 プレジデント アンド フェローズ オブ ハーバード カレッジ ヌクレアーゼ切断特異性の評価および改善
US20150017136A1 (en) * 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
US20230050345A1 (en) * 2013-05-13 2023-02-16 Cellectis Methods for engineering allogeneic and highly active t cell for immunotheraphy
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
AU2014346559B2 (en) 2013-11-07 2020-07-09 Editas Medicine,Inc. CRISPR-related methods and compositions with governing gRNAs
US10357515B2 (en) * 2013-11-22 2019-07-23 Cellectis Method for generating batches of allogeneic T-cells with averaged potency
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
WO2015092024A2 (en) * 2013-12-20 2015-06-25 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
CA2943008C (en) 2014-03-19 2021-03-30 Cellectis Cd123 specific chimeric antigen receptors for cancer immunotherapy
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
WO2016069282A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Altering gene expression in modified t cells and uses thereof
ES2869972T3 (es) 2015-01-26 2021-10-26 Cellectis Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas
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