ES2803728T3 - Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado - Google Patents

Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado Download PDF

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Publication number
ES2803728T3
ES2803728T3 ES16782371T ES16782371T ES2803728T3 ES 2803728 T3 ES2803728 T3 ES 2803728T3 ES 16782371 T ES16782371 T ES 16782371T ES 16782371 T ES16782371 T ES 16782371T ES 2803728 T3 ES2803728 T3 ES 2803728T3
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seq
trc
cells
sequence
meganuclease
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Derek Jantz
James Smith
Michael Nicholson
Daniel Macleod
Jeyaraj Antony
Victor Bartsevich
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Precision Biosciences Inc
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Precision Biosciences Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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ES16782371T 2015-10-05 2016-10-05 Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado Active ES2803728T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562237394P 2015-10-05 2015-10-05
US201662297426P 2016-02-19 2016-02-19
PCT/US2016/055492 WO2017062451A1 (en) 2015-10-05 2016-10-05 Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

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ES2803728T3 true ES2803728T3 (es) 2021-01-29

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ES16782371T Active ES2803728T3 (es) 2015-10-05 2016-10-05 Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado
ES20172471T Active ES2920525T3 (es) 2015-10-05 2016-10-05 Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado

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ES20172471T Active ES2920525T3 (es) 2015-10-05 2016-10-05 Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado

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US (14) US9889161B2 (enExample)
EP (3) EP4108255A1 (enExample)
JP (6) JP6816133B2 (enExample)
KR (2) KR20180054886A (enExample)
CN (2) CN117070468A (enExample)
AU (3) AU2016333898B2 (enExample)
CA (1) CA3001011A1 (enExample)
DK (2) DK3756682T3 (enExample)
ES (2) ES2803728T3 (enExample)
IL (5) IL296340A (enExample)
MX (2) MX2018004146A (enExample)
WO (1) WO2017062451A1 (enExample)

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US20150320799A1 (en) 2012-12-20 2015-11-12 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
KR20180029201A (ko) 2015-05-18 2018-03-20 티씨알2 테라퓨틱스 인크. 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법
WO2017011519A1 (en) * 2015-07-13 2017-01-19 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
AU2016333886B2 (en) 2015-10-05 2020-10-08 Precision Biosciences, Inc. Engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene
EP4108255A1 (en) * 2015-10-05 2022-12-28 Precision Biosciences, Inc. Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene
KR20250141836A (ko) * 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
CN108473961B (zh) 2015-11-04 2022-11-29 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
SG11201807538PA (en) * 2016-03-04 2018-09-27 Editas Medicine Inc Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Ｃａｒ ｔ細胞療法のための方法および組成物
CA3020923A1 (en) * 2016-04-15 2017-10-19 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
WO2018026953A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
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