ES2768648T3 - Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento - Google Patents
Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361806687P | 2013-03-29 | 2013-03-29 | |
| PCT/US2014/032209 WO2014160958A1 (en) | 2013-03-29 | 2014-03-28 | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
Publications (1)
| Publication Number | Publication Date |
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| ES2768648T3 true ES2768648T3 (es) | 2020-06-23 |
Family
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Family Applications (1)
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| ES14722916T Active ES2768648T3 (es) | 2013-03-29 | 2014-03-28 | Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento |
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| EP (2) | EP3473272A1 (OSRAM) |
| JP (2) | JP6505079B2 (OSRAM) |
| CA (1) | CA2897334A1 (OSRAM) |
| ES (1) | ES2768648T3 (OSRAM) |
| WO (1) | WO2014160958A1 (OSRAM) |
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| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| BR112013013354A2 (pt) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| KR102605775B1 (ko) | 2013-03-14 | 2023-11-29 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 성분 Ｃ5 ｉＲＮＡ 조성물 및 그 이용 방법 |
| EP3191591A1 (en) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| MY181199A (en) | 2014-12-19 | 2020-12-21 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| JP2018520139A (ja) * | 2015-06-26 | 2018-07-26 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | エクリズマブまたはエクリズマブバリアントでのワクチン接種に従って患者を処置するための方法 |
| WO2017044811A1 (en) * | 2015-09-11 | 2017-03-16 | Bruce Andrien | Recombinant glycosylated eculizumab and eculizumab variants |
| MY196006A (en) | 2016-06-14 | 2023-03-06 | Regeneron Pharma | Anti-C5 Antibodies and Uses Thereof |
| WO2017217524A1 (en) * | 2016-06-17 | 2017-12-21 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
| JP6527643B2 (ja) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Ｉｌ−８関連疾患の治療用又は予防用組成物 |
| ES2888904T3 (es) * | 2016-10-19 | 2022-01-10 | Alexion Pharma Inc | Un método de cuantificación de C5a sin unir en una muestra |
| WO2018075758A1 (en) * | 2016-10-19 | 2018-04-26 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5 in a sample |
| IL268327B2 (en) * | 2017-01-31 | 2025-09-01 | Chugai Pharmaceutical Co Ltd | Pharmaceutical preparation for use in the treatment and prevention of C5-related diseases and methods for the treatment and prevention of C5-related diseases |
| JP7209637B2 (ja) * | 2017-04-21 | 2023-01-20 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 自己免疫性水疱症の治療のためのコバーシン |
| KR20200098528A (ko) | 2017-12-13 | 2020-08-20 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 조합물 및 이의 용도 |
| EP3597222A1 (en) * | 2018-07-16 | 2020-01-22 | Easemedcontrol R & D GmbH & Co KG | Treatment and diagnosis of unresolved inflammatory diseases |
| EP3846850A4 (en) * | 2018-09-06 | 2022-06-15 | The Trustees of the University of Pennsylvania | HUMANIZED ANTI-C5 ANTIBODIES AND USES THEREOF |
| JP7654564B2 (ja) * | 2019-04-24 | 2025-04-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 二機能性ヒト化抗ｃ５抗体ならびにそのｈ因子融合タンパク質およびその使用 |
| WO2021154941A1 (en) * | 2020-01-31 | 2021-08-05 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als) |
| US20240417725A1 (en) * | 2021-10-12 | 2024-12-19 | Vanqua Bio, Inc. | Oligonucleotides for targeting complement c5 |
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| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
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| MX2011001371A (es) | 2008-08-05 | 2011-06-16 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complementos c5. |
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| US20100291106A1 (en) | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
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| BR112012022214A2 (pt) | 2010-03-01 | 2017-07-04 | Alexion Pharma Inc | métodos e composições para tratar doença de degos |
| KR102605775B1 (ko) | 2013-03-14 | 2023-11-29 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 성분 Ｃ5 ｉＲＮＡ 조성물 및 그 이용 방법 |
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2014
- 2014-03-28 ES ES14722916T patent/ES2768648T3/es active Active
- 2014-03-28 WO PCT/US2014/032209 patent/WO2014160958A1/en not_active Ceased
- 2014-03-28 EP EP18211716.8A patent/EP3473272A1/en not_active Withdrawn
- 2014-03-28 CA CA2897334A patent/CA2897334A1/en not_active Abandoned
- 2014-03-28 JP JP2016505600A patent/JP6505079B2/ja active Active
- 2014-03-28 US US14/779,605 patent/US20160051673A1/en not_active Abandoned
- 2014-03-28 EP EP14722916.5A patent/EP2978451B1/en not_active Revoked
-
2018
- 2018-04-19 JP JP2018080510A patent/JP6505288B2/ja active Active
-
2019
- 2019-05-29 US US16/425,402 patent/US20200023060A1/en not_active Abandoned
-
2023
- 2023-10-06 US US18/482,159 patent/US20240293540A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP6505288B2 (ja) | 2019-04-24 |
| US20200023060A1 (en) | 2020-01-23 |
| EP3473272A1 (en) | 2019-04-24 |
| JP6505079B2 (ja) | 2019-04-24 |
| CA2897334A1 (en) | 2014-10-02 |
| US20240293540A1 (en) | 2024-09-05 |
| EP2978451B1 (en) | 2019-11-27 |
| EP2978451A1 (en) | 2016-02-03 |
| WO2014160958A1 (en) | 2014-10-02 |
| JP2016520542A (ja) | 2016-07-14 |
| US20160051673A1 (en) | 2016-02-25 |
| JP2018111728A (ja) | 2018-07-19 |
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