ES2761568T3 - Adsorbente de micotoxinas y el uso del mismo en pienso equilibrado para animales - Google Patents
Adsorbente de micotoxinas y el uso del mismo en pienso equilibrado para animales Download PDFInfo
- Publication number
- ES2761568T3 ES2761568T3 ES14864455T ES14864455T ES2761568T3 ES 2761568 T3 ES2761568 T3 ES 2761568T3 ES 14864455 T ES14864455 T ES 14864455T ES 14864455 T ES14864455 T ES 14864455T ES 2761568 T3 ES2761568 T3 ES 2761568T3
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- Prior art keywords
- mycotoxin
- adsorbent
- aluminum silicate
- mycotoxin adsorbent
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2013013788A MX338482B (es) | 2013-11-25 | 2013-11-25 | Absorbente de micotoxinas y su uso en alimentos balanceados para animales. |
| PCT/IB2014/066246 WO2015075686A1 (es) | 2013-11-25 | 2014-11-21 | Absorbente de micotoxinas y su uso en alimentos balanceados para animales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2761568T3 true ES2761568T3 (es) | 2020-05-20 |
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ID=53179054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14864455T Active ES2761568T3 (es) | 2013-11-25 | 2014-11-21 | Adsorbente de micotoxinas y el uso del mismo en pienso equilibrado para animales |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160287617A1 (enExample) |
| EP (1) | EP3075260B1 (enExample) |
| JP (1) | JP6387097B2 (enExample) |
| CN (1) | CN105792665B (enExample) |
| CA (1) | CA2930547C (enExample) |
| CL (1) | CL2016001264A1 (enExample) |
| ES (1) | ES2761568T3 (enExample) |
| MX (1) | MX338482B (enExample) |
| PE (1) | PE20160684A1 (enExample) |
| RS (1) | RS59791B1 (enExample) |
| WO (1) | WO2015075686A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX354792B (es) * | 2016-06-22 | 2018-03-21 | Nutek S A De C V | Adsorbente de micotoxinas con base en un derivado de betaina para alimentos balanceados de animales. |
| EP3430913B1 (en) | 2017-07-20 | 2020-12-02 | Tolsa, S.A. | Composition for binding mycotoxins and its use |
| EP3840590A4 (en) * | 2018-08-20 | 2022-05-18 | Texas A&M University | Edible enterosorbents used to mitigate acute exposures to ingestible environmental toxins following outbreaks, natural disasters and emergencies |
| CN109364885B (zh) * | 2018-11-24 | 2021-03-12 | 烟台大学 | 羧甲基纤维素钠-胶原-蒙脱土复合黄曲霉菌吸附材料的制备方法 |
| CN109939648B (zh) * | 2019-03-15 | 2023-04-14 | 上海岩康生物科技有限公司 | 一种复合型广谱性霉菌毒素吸附剂及其制备方法 |
| CN110776568B (zh) * | 2019-11-15 | 2023-04-18 | 中国农业科学院油料作物研究所 | 净化伏马毒素b1、蛇形毒素、t-2毒素、玉米赤霉烯酮、呕吐毒素复合亲和柱 |
| CN111298775B (zh) * | 2020-03-03 | 2022-04-26 | 武汉轻工大学 | 一种甲壳素磁性微球吸附剂及其制备方法和应用 |
| DE102020115832B3 (de) | 2020-06-16 | 2021-12-16 | AdFiS products GmbH | Mykotoxin-Adsorber auf Basis von Aktivkohle |
| WO2022243722A1 (es) * | 2021-05-17 | 2022-11-24 | Nutek, S.A. De C.V. | Uso de un adsorbente de fumonisina b1 y zearalenona en alimentos balanceados para animales |
| CN113713777B (zh) * | 2021-09-13 | 2024-01-09 | 湖南农业大学 | 蛋壳粉呕吐毒素吸附剂的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH443774A (de) * | 1963-05-30 | 1967-09-15 | Ciba Geigy | Mittel zur Bekämpfung phytopathogener Mikroorganismen |
| DE3126522A1 (de) * | 1981-07-04 | 1983-01-20 | Basf Ag, 6700 Ludwigshafen | Quaternaere ammoniumsalze und verfahren zu ihrer herstellung |
| DE3810004A1 (de) | 1988-03-24 | 1989-10-05 | Siegfried Dr Moser | Verwendung von bentoniten zur mykotoxinbindung |
| BR9105978A (pt) | 1990-03-07 | 1992-11-17 | Engelhard Corp | Aditivo de forragem particulado,e composicao de forragem |
| DE19900813A1 (de) | 1999-01-12 | 2000-07-13 | Sued Chemie Ag | Mykotoxin-Adsorbens |
| MXPA00007077A (es) * | 2000-07-19 | 2003-09-08 | Nutek S A De C V | Proceso para preparar organoaluminosilicatos y su uso en alimentos balanceados para animales. |
| DE10056634A1 (de) | 2000-11-15 | 2002-05-29 | Sued Chemie Ag | Verwendung Aktivierter Schichtsilicate zur Mykotoxinadsorption |
| HUP0300377A3 (en) * | 2000-12-28 | 2003-07-28 | Inst Za Technologiju Nuklearni | Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application |
| DE60232058D1 (de) * | 2001-02-15 | 2009-06-04 | Patent Co | Verfahren zur tribochemischen gewinnung eines organozeolithen als adsorbens für mycotoxine, |
| ZA200710203B (en) | 2005-05-10 | 2010-08-25 | Sued Chemie Ag | Use of stevensite for mycotoxin adsorption |
| JP4295761B2 (ja) * | 2005-12-27 | 2009-07-15 | 学校法人酪農学園 | マイコトキシン除去用飼料添加剤 |
| US9597313B2 (en) * | 2006-06-27 | 2017-03-21 | Timothy D. Phillips | Composition and methods for the enterosorption and management of toxins |
| KR20090034506A (ko) * | 2007-10-04 | 2009-04-08 | 주식회사 카이로라이트 | 악취 및 VOC's 제거기능을 갖는 친유성 실리케이트 및그 제조방법 |
| EP2279787B1 (en) | 2009-06-29 | 2012-08-08 | Adiveter S.L. | Mycotoxin adsorbent |
| EP2289617A1 (en) | 2009-08-27 | 2011-03-02 | Süd-Chemie AG | Toxin adsorbent |
| WO2012037297A1 (en) | 2010-09-16 | 2012-03-22 | Cubena, Inc. | Mycotoxin binding food and feed additives and processing aids, fungistatic and bacteriostatic plant protecting agents and methods of utilizing the same |
| ES2690550T3 (es) * | 2011-01-13 | 2018-11-21 | Austin Research Labs Corp. | Dispersiones de alta carga para el tratamiento de infecciones |
| CN102847509B (zh) * | 2012-04-17 | 2014-05-14 | 东北农业大学 | 一种饲料霉菌毒素吸附剂及其制备方法 |
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- 2014-11-21 EP EP14864455.2A patent/EP3075260B1/en not_active Not-in-force
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| JP2016539949A (ja) | 2016-12-22 |
| EP3075260A4 (en) | 2017-08-09 |
| CN105792665A (zh) | 2016-07-20 |
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| PE20160684A1 (es) | 2016-07-20 |
| CA2930547C (en) | 2021-03-09 |
| EP3075260A9 (en) | 2016-11-30 |
| US20160287617A1 (en) | 2016-10-06 |
| JP6387097B2 (ja) | 2018-09-05 |
| EP3075260A1 (en) | 2016-10-05 |
| EP3075260B1 (en) | 2019-09-11 |
| WO2015075686A1 (es) | 2015-05-28 |
| CN105792665B (zh) | 2018-02-09 |
| CL2016001264A1 (es) | 2017-02-03 |
| MX2013013788A (es) | 2015-05-25 |
| CA2930547A1 (en) | 2015-05-28 |
| MX338482B (es) | 2016-04-19 |
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