CA2930547C - Mycotoxin adsorbents and use thereof in balanced animal feed. - Google Patents

Mycotoxin adsorbents and use thereof in balanced animal feed. Download PDF

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Publication number
CA2930547C
CA2930547C CA2930547A CA2930547A CA2930547C CA 2930547 C CA2930547 C CA 2930547C CA 2930547 A CA2930547 A CA 2930547A CA 2930547 A CA2930547 A CA 2930547A CA 2930547 C CA2930547 C CA 2930547C
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CA
Canada
Prior art keywords
aluminum silicate
adsorbent
mycotoxin adsorbent
mycotoxin
trichothecene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2930547A
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English (en)
French (fr)
Other versions
CA2930547A1 (en
Inventor
Javier Armando Lara Arellano
Miguel Angel Romero Martinez Del Sobral
Irlanda Veronica Garcia Rosas
Jose Antonio Fierro Huesca
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Nutek SA de CV
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Nutek SA de CV
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/12—Naturally occurring clays or bleaching earth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/223—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material containing metals, e.g. organo-metallic compounds, coordination complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/02—Processes using inorganic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/14—Base exchange silicates, e.g. zeolites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/17—Organic material containing also inorganic materials, e.g. inert material coated with an ion-exchange resin
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C01B39/36—Pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
    • C01B39/38—Type ZSM-5
    • C01B39/40—Type ZSM-5 using at least one organic template directing agent
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
    • C01B39/44—Ferrierite type, e.g. types ZSM-21, ZSM-35 or ZSM-38
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Birds (AREA)
  • Toxicology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2930547A 2013-11-25 2014-11-21 Mycotoxin adsorbents and use thereof in balanced animal feed. Expired - Fee Related CA2930547C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
MX2013013788A MX338482B (es) 2013-11-25 2013-11-25 Absorbente de micotoxinas y su uso en alimentos balanceados para animales.
MXMX/A/2013/013788 2013-11-25
PCT/IB2014/066246 WO2015075686A1 (es) 2013-11-25 2014-11-21 Absorbente de micotoxinas y su uso en alimentos balanceados para animales

Publications (2)

Publication Number Publication Date
CA2930547A1 CA2930547A1 (en) 2015-05-28
CA2930547C true CA2930547C (en) 2021-03-09

Family

ID=53179054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2930547A Expired - Fee Related CA2930547C (en) 2013-11-25 2014-11-21 Mycotoxin adsorbents and use thereof in balanced animal feed.

Country Status (11)

Country Link
US (1) US20160287617A1 (enExample)
EP (1) EP3075260B1 (enExample)
JP (1) JP6387097B2 (enExample)
CN (1) CN105792665B (enExample)
CA (1) CA2930547C (enExample)
CL (1) CL2016001264A1 (enExample)
ES (1) ES2761568T3 (enExample)
MX (1) MX338482B (enExample)
PE (1) PE20160684A1 (enExample)
RS (1) RS59791B1 (enExample)
WO (1) WO2015075686A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354792B (es) 2016-06-22 2018-03-21 Nutek S A De C V Adsorbente de micotoxinas con base en un derivado de betaina para alimentos balanceados de animales.
PL3430913T3 (pl) 2017-07-20 2021-05-31 Tolsa, S.A. Kompozycja do wiązania mykotoksyn i jej zastosowanie
US12622925B2 (en) * 2018-08-20 2026-05-12 Texas A&M University Edible enterosorbents used to mitigate acute exposures to ingestible environmental toxins following outbreaks, natural disasters and emergencies
CN109364885B (zh) * 2018-11-24 2021-03-12 烟台大学 羧甲基纤维素钠-胶原-蒙脱土复合黄曲霉菌吸附材料的制备方法
CN109939648B (zh) * 2019-03-15 2023-04-14 上海岩康生物科技有限公司 一种复合型广谱性霉菌毒素吸附剂及其制备方法
CN110776568B (zh) * 2019-11-15 2023-04-18 中国农业科学院油料作物研究所 净化伏马毒素b1、蛇形毒素、t-2毒素、玉米赤霉烯酮、呕吐毒素复合亲和柱
CN111298775B (zh) * 2020-03-03 2022-04-26 武汉轻工大学 一种甲壳素磁性微球吸附剂及其制备方法和应用
DE102020115832B3 (de) 2020-06-16 2021-12-16 AdFiS products GmbH Mykotoxin-Adsorber auf Basis von Aktivkohle
WO2022243722A1 (es) * 2021-05-17 2022-11-24 Nutek, S.A. De C.V. Uso de un adsorbente de fumonisina b1 y zearalenona en alimentos balanceados para animales
CN113713777B (zh) * 2021-09-13 2024-01-09 湖南农业大学 蛋壳粉呕吐毒素吸附剂的制备方法

Family Cites Families (18)

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CH443774A (de) * 1963-05-30 1967-09-15 Ciba Geigy Mittel zur Bekämpfung phytopathogener Mikroorganismen
DE3126522A1 (de) * 1981-07-04 1983-01-20 Basf Ag, 6700 Ludwigshafen Quaternaere ammoniumsalze und verfahren zu ihrer herstellung
DE3810004A1 (de) 1988-03-24 1989-10-05 Siegfried Dr Moser Verwendung von bentoniten zur mykotoxinbindung
EP0518956A4 (en) 1990-03-07 1993-01-27 Engelhard Corporation Animal feed additive and method for inactivating mycotoxins present in animal feeds
DE19900813A1 (de) 1999-01-12 2000-07-13 Sued Chemie Ag Mykotoxin-Adsorbens
MXPA00007077A (es) * 2000-07-19 2003-09-08 Nutek S A De C V Proceso para preparar organoaluminosilicatos y su uso en alimentos balanceados para animales.
DE10056634A1 (de) 2000-11-15 2002-05-29 Sued Chemie Ag Verwendung Aktivierter Schichtsilicate zur Mykotoxinadsorption
SK12362002A3 (sk) * 2000-12-28 2003-01-09 Institut Za Technologiju Nuklearnih I Drugih Organominerálny adsorbent mykotoxínu ako prísada do krmiva, spôsob jeho prípravy a jeho použitie
EP1363854B1 (en) * 2001-02-15 2009-04-22 PATENT CO., preduzece za proizvodnju, usluge i promet d.o.o. Misicevo Tribochemical process for obtaining organozeolite adsorbent of mycotoxins
ZA200710203B (en) 2005-05-10 2010-08-25 Sued Chemie Ag Use of stevensite for mycotoxin adsorption
JP4295761B2 (ja) * 2005-12-27 2009-07-15 学校法人酪農学園 マイコトキシン除去用飼料添加剤
US9597313B2 (en) * 2006-06-27 2017-03-21 Timothy D. Phillips Composition and methods for the enterosorption and management of toxins
KR20090034506A (ko) * 2007-10-04 2009-04-08 주식회사 카이로라이트 악취 및 ＶＯＣ'ｓ 제거기능을 갖는 친유성 실리케이트 및그 제조방법
PT2279787E (pt) 2009-06-29 2012-10-18 Adiveter S L Adsorvente de micotoxina
EP2289617A1 (en) 2009-08-27 2011-03-02 Süd-Chemie AG Toxin adsorbent
WO2012037297A1 (en) 2010-09-16 2012-03-22 Cubena, Inc. Mycotoxin binding food and feed additives and processing aids, fungistatic and bacteriostatic plant protecting agents and methods of utilizing the same
ES2690550T3 (es) * 2011-01-13 2018-11-21 Austin Research Labs Corp. Dispersiones de alta carga para el tratamiento de infecciones
CN102847509B (zh) * 2012-04-17 2014-05-14 东北农业大学 一种饲料霉菌毒素吸附剂及其制备方法

Also Published As

Publication number Publication date
US20160287617A1 (en) 2016-10-06
CN105792665B (zh) 2018-02-09
MX2013013788A (es) 2015-05-25
EP3075260A9 (en) 2016-11-30
CL2016001264A1 (es) 2017-02-03
EP3075260B1 (en) 2019-09-11
JP6387097B2 (ja) 2018-09-05
CN105792665A (zh) 2016-07-20
WO2015075686A1 (es) 2015-05-28
JP2016539949A (ja) 2016-12-22
MX338482B (es) 2016-04-19
ES2761568T3 (es) 2020-05-20
RS59791B1 (sr) 2020-02-28
EP3075260A1 (en) 2016-10-05
EP3075260A4 (en) 2017-08-09
CA2930547A1 (en) 2015-05-28
PE20160684A1 (es) 2016-07-20

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