ES2748050T3 - Cuerpos cetónicos y esteres de cuerpos cetónicos para mantener o mejorar la potencia muscular disponible - Google Patents
Cuerpos cetónicos y esteres de cuerpos cetónicos para mantener o mejorar la potencia muscular disponible Download PDFInfo
- Publication number
- ES2748050T3 ES2748050T3 ES13718524T ES13718524T ES2748050T3 ES 2748050 T3 ES2748050 T3 ES 2748050T3 ES 13718524 T ES13718524 T ES 13718524T ES 13718524 T ES13718524 T ES 13718524T ES 2748050 T3 ES2748050 T3 ES 2748050T3
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- Prior art keywords
- ketone
- hydroxybutyrate
- blood
- composition
- monoester
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
Landscapes
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
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| PCT/EP2013/057250 WO2013150153A1 (en) | 2012-04-05 | 2013-04-05 | Ketone bodies and ketone body esters for maintaining or improving muscle power output |
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| ES2748050T3 true ES2748050T3 (es) | 2020-03-12 |
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| US20060280721A1 (en) | 2003-06-03 | 2006-12-14 | The Gov Of Usa Represented By Secretary Of Dpt Of | Nutritional supplements and therapeutic compositions comprising (r)-3- hydroxybutyrate derivatives |
| CN106038532B (zh) | 2008-01-04 | 2019-05-14 | 牛津大学科技创新有限公司 | 用作降低血脂药剂的酮体和酮体酯 |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
| DK2914251T3 (da) | 2012-11-05 | 2019-11-04 | Us Health | Ketonlegemer til beskyttelse af væv mod beskadigelse som følge af ioniseringsstråling |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| EP2984066B1 (en) | 2013-03-14 | 2017-02-01 | Oxford University Innovation Limited | Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate |
| PE20151949A1 (es) | 2013-03-19 | 2016-01-05 | Univ South Florida | Composiciones y metodos para producir cetosis elevada y sostenida |
| GB201314127D0 (en) * | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| JP2015141458A (ja) * | 2014-01-27 | 2015-08-03 | 株式会社タニタ | ダイエット支援装置、方法、及びプログラム |
| JP6721583B2 (ja) * | 2014-07-21 | 2020-07-15 | オウルン イリオピストＯｕｌｕｎ Ｙｌｉｏｐｉｓｔｏ | ３−ヒドロキシブチラートのオリゴマー体 |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10245243B1 (en) * | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10245242B1 (en) * | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| WO2017165445A1 (en) * | 2016-03-21 | 2017-09-28 | Csilla Ari D'agostino | Administration of exogenous ketone to lower blood glucose |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| EP4245368A3 (en) | 2016-12-21 | 2024-01-03 | Universitäts-kinderspital Beider Basel | Migraine prevention and treatment |
| CN110248652B (zh) * | 2016-12-23 | 2023-05-26 | 鲁汶大学 | 3-羟基丁酸单独或组合用于治疗重症监护治疗 |
| JP2020512351A (ja) | 2017-03-31 | 2020-04-23 | ジェノマティカ， インコーポレイテッド | 発酵ブロスから１，３−ブタンジオールを取得するためのプロセスおよびシステム |
| BR112019020461A2 (pt) | 2017-03-31 | 2020-06-09 | Genomatica Inc | variantes de aldeído desidrogenase e métodos de uso |
| WO2018183640A1 (en) | 2017-03-31 | 2018-10-04 | Genomatica, Inc. | 3-hydroxybutyryl-coa dehydrogenase variants and methods of use |
| US20190231742A1 (en) * | 2017-04-20 | 2019-08-01 | Theodore B. VANITALLIE | Nutritional agents used to prevent and treat hypersensitivity and other allergic-type disorders |
| GB201710229D0 (en) * | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
| US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
| GB201715654D0 (en) | 2017-09-27 | 2017-11-08 | Tdeltas Ltd | Method of treatment |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
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| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
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| US11919851B2 (en) * | 2019-01-17 | 2024-03-05 | Ketolipix Therapeutics Gmbh | Method for producing polyol-based esters of optionally acylated hydroxycarboxylic acids |
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| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| EP4114203A1 (en) | 2020-03-05 | 2023-01-11 | VitaNav, Inc. | COMPOSITION OF (D)-ß-HYDROXYBUTYRIC ACID, (D)-ß-HYDROXYVALERIC ACID, AND (D)-1,3 BUTANEDIOL AS A NUTRITIONAL SUPPLEMENT AND THERAPEUTIC AGENT |
| WO2021195477A1 (en) | 2020-03-27 | 2021-09-30 | Ketoneaid, Inc. | Ketone ester as a therapeutic treatment of covid-19, long covid, and related viral infections |
| JP7737231B2 (ja) * | 2020-03-31 | 2025-09-10 | 大阪瓦斯株式会社 | ジオール化合物およびその重合体ならびにそれらの製造方法 |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| MX2023014990A (es) | 2021-07-17 | 2024-02-14 | Ketoswiss Ag | Combinacion de un cuerpo cetonico o compuesto cetogenico con un analgesico o antioxidante. |
| US11807600B2 (en) | 2021-11-12 | 2023-11-07 | Samuel J. Rozzoni | Synthesis of novel ketone body analogs for use as a nutritional supplement |
| IL312317B2 (en) * | 2021-11-12 | 2025-04-01 | Arxada Ag | Polyol-derived compounds |
| GB202219317D0 (en) * | 2022-12-20 | 2023-02-01 | Amazentis Sa | Methods for improving mitophagy in subjects |
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| WO1995009144A1 (en) * | 1993-09-30 | 1995-04-06 | Eastman Chemical Company | Nutritive water soluble glycerol esters of hydroxy butyric acid |
| JP4598203B2 (ja) | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| WO2004105742A1 (en) | 2003-06-02 | 2004-12-09 | Isis Innovation Limited | Treatment of muscle fatigue |
| US20060280721A1 (en) * | 2003-06-03 | 2006-12-14 | The Gov Of Usa Represented By Secretary Of Dpt Of | Nutritional supplements and therapeutic compositions comprising (r)-3- hydroxybutyrate derivatives |
| US7117715B2 (en) * | 2004-07-09 | 2006-10-10 | Owens-Brockway Glass Container Inc. | Servo mechanism test stand |
| US7947736B2 (en) * | 2004-07-16 | 2011-05-24 | Btg International Limited | Oligomeric compounds |
| PL3296284T3 (pl) * | 2008-08-21 | 2022-06-13 | The Government Of The United States Of America, As Repres. By The Secretary Of Health And Human Services, Nat. Inst. Of Health | Nieterapeutyczne zastosowanie estru hydroksymaślanowego |
| US8642654B2 (en) * | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| GB201002983D0 (en) * | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
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| EP2833882B1 (en) | 2019-07-24 |
| GB201206192D0 (en) | 2012-05-23 |
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| JP6241956B2 (ja) | 2017-12-06 |
| EP2833882A1 (en) | 2015-02-11 |
| AU2013244931B2 (en) | 2018-01-18 |
| JP2015514104A (ja) | 2015-05-18 |
| US20150164855A1 (en) | 2015-06-18 |
| AU2013244931A1 (en) | 2014-11-20 |
| CA2873092A1 (en) | 2013-10-10 |
| HK1206999A1 (en) | 2016-01-22 |
| CA2873092C (en) | 2020-08-04 |
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