ES2729165T3 - Moléculas de unión a ANG2 - Google Patents
Moléculas de unión a ANG2 Download PDFInfo
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- ES2729165T3 ES2729165T3 ES13718796T ES13718796T ES2729165T3 ES 2729165 T3 ES2729165 T3 ES 2729165T3 ES 13718796 T ES13718796 T ES 13718796T ES 13718796 T ES13718796 T ES 13718796T ES 2729165 T3 ES2729165 T3 ES 2729165T3
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- ang2
- vhh
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12162615 | 2012-03-30 | ||
| PCT/EP2013/056635 WO2013144266A1 (en) | 2012-03-30 | 2013-03-27 | Ang2-binding molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2729165T3 true ES2729165T3 (es) | 2019-10-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13718796T Active ES2729165T3 (es) | 2012-03-30 | 2013-03-27 | Moléculas de unión a ANG2 |
Country Status (27)
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| US (5) | US20130259859A1 (OSRAM) |
| EP (1) | EP2831111B1 (OSRAM) |
| JP (1) | JP5970734B2 (OSRAM) |
| KR (1) | KR102020255B1 (OSRAM) |
| CN (1) | CN104321344B (OSRAM) |
| AU (1) | AU2013241769B2 (OSRAM) |
| BR (1) | BR112014023415B1 (OSRAM) |
| CA (1) | CA2865464C (OSRAM) |
| CL (1) | CL2014002393A1 (OSRAM) |
| CY (1) | CY1122007T1 (OSRAM) |
| DK (1) | DK2831111T3 (OSRAM) |
| EA (1) | EA031182B1 (OSRAM) |
| ES (1) | ES2729165T3 (OSRAM) |
| HR (1) | HRP20190817T1 (OSRAM) |
| HU (1) | HUE044263T2 (OSRAM) |
| IL (1) | IL234234B (OSRAM) |
| IN (1) | IN2014DN06904A (OSRAM) |
| LT (1) | LT2831111T (OSRAM) |
| MX (1) | MX350248B (OSRAM) |
| NZ (1) | NZ628584A (OSRAM) |
| PH (1) | PH12014502179B1 (OSRAM) |
| PL (1) | PL2831111T3 (OSRAM) |
| PT (1) | PT2831111T (OSRAM) |
| RS (1) | RS58732B1 (OSRAM) |
| SI (1) | SI2831111T1 (OSRAM) |
| TR (1) | TR201908638T4 (OSRAM) |
| WO (1) | WO2013144266A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US20170248603A1 (en) | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
| AU2015331602A1 (en) | 2014-10-17 | 2017-04-27 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies |
| KR102789821B1 (ko) * | 2015-03-31 | 2025-04-02 | 소리소 파마슈티컬스 인크. | 프로테아제-절단가능 링커를 갖는 펩티드 구조물 |
| EP3792279A3 (en) * | 2015-07-29 | 2021-07-07 | Allergan, Inc. | Heavy chain only antibodies to ang-2 |
| EP3526259A4 (en) * | 2016-10-13 | 2020-06-17 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE AND RESISTANCE TO CTLA4 BLOCKAGE IN MELANOMA USING GENE EXPRESSION SIGNATURE |
| KR102143132B1 (ko) * | 2016-12-26 | 2020-08-10 | 기초과학연구원 | 항 Ang2 항체를 포함하는 안구질환 예방 및 치료용 조성물 |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| CN110691790A (zh) * | 2017-06-02 | 2020-01-14 | 勃林格殷格翰国际有限公司 | 抗癌联合治疗 |
| CN108659130B (zh) * | 2018-05-28 | 2021-09-10 | 长春力太生物技术有限公司 | 一种抗癌胚抗原纳米抗体及其应用 |
| US11001635B2 (en) | 2018-06-29 | 2021-05-11 | Gensun Biopharma Inc. | Antitumor antagonists |
| JP7177284B2 (ja) * | 2019-02-25 | 2022-11-22 | ファームアブシン・インコーポレイテッド | 抗ａｎｇ２抗体及びその用途 |
| US20220185875A1 (en) * | 2019-03-18 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific antibody specifically bound to vegf and ang2 |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| CA3168939A1 (en) * | 2020-03-03 | 2021-09-10 | Aptitude Medical Systems, Inc. | Aptamers and use thereof |
| CN111875706B (zh) * | 2020-07-16 | 2021-03-30 | 广州康盛生物科技股份有限公司 | 一种抗人IgE蛋白的单域抗体及其应用 |
| US20220389120A1 (en) | 2021-06-03 | 2022-12-08 | Gensun Biopharma Inc. | Multispecific antagonists |
| KR20240048555A (ko) * | 2021-09-10 | 2024-04-15 | 소테르 바이오파마 피티이. 리미티드 | 항 ang2 항체 및 그 제조방법과 응용 |
| WO2024065268A1 (zh) | 2022-09-28 | 2024-04-04 | 科兴生物制药股份有限公司 | 能够识别ang-2的抗体或抗原结合片段和同时识别vegf和ang-2的双抗 |
| CN115819592A (zh) * | 2022-12-27 | 2023-03-21 | 上海医药集团生物治疗技术有限公司 | 靶向ror1的抗原结合蛋白 |
| WO2025117641A2 (en) * | 2023-12-01 | 2025-06-05 | Tavotek Biotherapeutics (Hong Kong) Limited | ANTIBODIES TARGETING DISEASE ASSOCIATED ANTIGEN AND γδ T CELL RECEPTORS AND USES THEREOF |
| WO2025137089A1 (en) * | 2023-12-19 | 2025-06-26 | Beam Therapeutics Inc. | Cd19-binding polypeptides, compositions comprising the same, and methods for use thereof |
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| ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| CN1911965B (zh) | 2001-01-17 | 2013-05-29 | 新兴产品开发西雅图有限公司 | 结合域-免疫球蛋白融合蛋白 |
| EP1399484B1 (en) | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1558650A2 (en) | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
| EP2251357A1 (en) | 2003-11-07 | 2010-11-17 | Ablynx N.V. | Camelidae single domain antibodies VHH directed against epidermal growth factor receptor and uses therefor |
| US20050284249A1 (en) | 2004-06-29 | 2005-12-29 | Arnone David F | Worm type gear mover assembly |
| US20080107601A1 (en) | 2004-10-13 | 2008-05-08 | Ablynx N.V. | Nanobodies Tm Against Amyloid-Beta and Polypeptides Comprising the Same for the Treatment of Degenerative Neural Diseases Such as Alzheimer's Disease |
| US20080267971A1 (en) | 2004-12-21 | 2008-10-30 | Green Larry L | Antibodies Directed to Angiopoietin-2 and Uses Thereof |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| CA2654304A1 (en) | 2006-06-06 | 2007-12-13 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| AU2008219216A1 (en) | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| EP2247616A2 (en) | 2008-03-05 | 2010-11-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making and uses thereof |
| AU2009254501B2 (en) * | 2008-06-05 | 2014-07-31 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
| JP5823871B2 (ja) * | 2008-12-10 | 2015-11-25 | アブリンクス エン．ヴェー． | 血管新生に関連した疾患及び障害の治療のための、アンジオポイエチン／Ｔｉｅシステムに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| US9527925B2 (en) * | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
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2013
- 2013-03-27 MX MX2014011171A patent/MX350248B/es active IP Right Grant
- 2013-03-27 CN CN201380026471.3A patent/CN104321344B/zh active Active
- 2013-03-27 PT PT13718796T patent/PT2831111T/pt unknown
- 2013-03-27 IN IN6904DEN2014 patent/IN2014DN06904A/en unknown
- 2013-03-27 PL PL13718796T patent/PL2831111T3/pl unknown
- 2013-03-27 EA EA201401065A patent/EA031182B1/ru not_active IP Right Cessation
- 2013-03-27 HR HRP20190817TT patent/HRP20190817T1/hr unknown
- 2013-03-27 EP EP13718796.9A patent/EP2831111B1/en active Active
- 2013-03-27 KR KR1020147028419A patent/KR102020255B1/ko active Active
- 2013-03-27 JP JP2015502346A patent/JP5970734B2/ja active Active
- 2013-03-27 BR BR112014023415-9A patent/BR112014023415B1/pt active IP Right Grant
- 2013-03-27 AU AU2013241769A patent/AU2013241769B2/en not_active Ceased
- 2013-03-27 CA CA2865464A patent/CA2865464C/en active Active
- 2013-03-27 TR TR2019/08638T patent/TR201908638T4/tr unknown
- 2013-03-27 NZ NZ628584A patent/NZ628584A/en not_active IP Right Cessation
- 2013-03-27 RS RS20190627A patent/RS58732B1/sr unknown
- 2013-03-27 WO PCT/EP2013/056635 patent/WO2013144266A1/en not_active Ceased
- 2013-03-27 SI SI201331449T patent/SI2831111T1/sl unknown
- 2013-03-27 DK DK13718796.9T patent/DK2831111T3/en active
- 2013-03-27 ES ES13718796T patent/ES2729165T3/es active Active
- 2013-03-27 LT LTEP13718796.9T patent/LT2831111T/lt unknown
- 2013-03-27 HU HUE13718796 patent/HUE044263T2/hu unknown
- 2013-03-28 US US13/852,402 patent/US20130259859A1/en not_active Abandoned
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2014
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- 2014-09-10 CL CL2014002393A patent/CL2014002393A1/es unknown
- 2014-09-29 PH PH12014502179A patent/PH12014502179B1/en unknown
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2016
- 2016-12-21 US US15/386,181 patent/US20170107281A1/en not_active Abandoned
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2018
- 2018-07-02 US US16/025,067 patent/US20190135907A1/en not_active Abandoned
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2019
- 2019-06-18 CY CY20191100625T patent/CY1122007T1/el unknown
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2020
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2023
- 2023-03-17 US US18/185,493 patent/US20230203146A1/en active Pending
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