ES2688590T3 - Profármacos de amidas de piridona útiles como moduladores de los canales de sodio - Google Patents
Profármacos de amidas de piridona útiles como moduladores de los canales de sodio Download PDFInfo
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- ES2688590T3 ES2688590T3 ES14824658.0T ES14824658T ES2688590T3 ES 2688590 T3 ES2688590 T3 ES 2688590T3 ES 14824658 T ES14824658 T ES 14824658T ES 2688590 T3 ES2688590 T3 ES 2688590T3
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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Landscapes
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| PCT/US2014/069916 WO2015089361A1 (en) | 2013-12-13 | 2014-12-12 | Prodrugs of pyridone amides useful as modulators of sodium channels |
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| ES2857687T3 (es) | 2013-01-31 | 2021-09-29 | Vertex Pharma | Piridona amidas como moduladores de los canales de sodio |
| BR112016000825B1 (pt) | 2013-07-19 | 2023-04-25 | Vertex Pharmaceuticals Incorporated | Compostos moduladores de sulfonamidas dos canais de sódio, composição farmacêutica, e uso dos mesmos |
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| WO2017075222A1 (en) * | 2015-10-30 | 2017-05-04 | Lieber Institute For Brain Development | Treatment of neurological and neurodevelopmental diseases and disorders associated with aberrant ion channel expression and activity |
| US20170239183A1 (en) * | 2016-02-23 | 2017-08-24 | PixarBio Corporation | COMPOSITIONS COMPRISING NAv1.7 SELECTIVE INHIBITORS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME |
| KR20190005991A (ko) | 2016-05-13 | 2019-01-16 | 에어로믹스, 인코포레이티드 | 결정 |
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| CN111065383A (zh) | 2017-07-11 | 2020-04-24 | 沃泰克斯药物股份有限公司 | 用作钠通道调节剂的羧酰胺 |
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| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| CN112996774B (zh) * | 2019-01-25 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 2-氧代-1,2-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
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