ES2687949T3 - Procedimiento para producir una multiplicidad de zonas de medición sobre un chip así como chip con zonas de medición - Google Patents

Procedimiento para producir una multiplicidad de zonas de medición sobre un chip así como chip con zonas de medición Download PDF

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Publication number
ES2687949T3
ES2687949T3 ES14730740.9T ES14730740T ES2687949T3 ES 2687949 T3 ES2687949 T3 ES 2687949T3 ES 14730740 T ES14730740 T ES 14730740T ES 2687949 T3 ES2687949 T3 ES 2687949T3
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Prior art keywords
chip
measurement
measurement zones
zones
layer
Prior art date
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Active
Application number
ES14730740.9T
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English (en)
Spanish (es)
Inventor
Markus Schieber
Heinz SCHOEDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
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Boehringer Ingelheim Vetmedica GmbH
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    • H10P74/273
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10DINORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D64/00Electrodes of devices having potential barriers
    • H10D64/01Manufacture or treatment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614Delimitation of the attachment areas
    • B01J2219/00617Delimitation of the attachment areas by chemical means
    • B01J2219/00619Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00635Introduction of reactive groups to the surface by reactive plasma treatment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00653Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Power Engineering (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES14730740.9T 2013-05-30 2014-05-30 Procedimiento para producir una multiplicidad de zonas de medición sobre un chip así como chip con zonas de medición Active ES2687949T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102013210138 2013-05-30
DE102013210138.4A DE102013210138A1 (de) 2013-05-30 2013-05-30 Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
PCT/EP2014/001462 WO2014191114A2 (de) 2013-05-30 2014-05-30 Verfahren zum erzeugen einer vielzahl von messbereichen auf einem chip sowie chip mit messbereichen

Publications (1)

Publication Number Publication Date
ES2687949T3 true ES2687949T3 (es) 2018-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES14730740.9T Active ES2687949T3 (es) 2013-05-30 2014-05-30 Procedimiento para producir una multiplicidad de zonas de medición sobre un chip así como chip con zonas de medición

Country Status (12)

Country Link
US (2) US9735072B2 (enExample)
EP (1) EP3004858B1 (enExample)
JP (2) JP6453316B2 (enExample)
KR (1) KR20160015296A (enExample)
CN (2) CN105408739B (enExample)
BR (2) BR122017011406B1 (enExample)
CA (1) CA2912151C (enExample)
DE (1) DE102013210138A1 (enExample)
DK (1) DK3004858T3 (enExample)
ES (1) ES2687949T3 (enExample)
PL (1) PL3004858T3 (enExample)
WO (1) WO2014191114A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013210138A1 (de) 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
KR20180088722A (ko) 2015-12-02 2018-08-06 베링거잉겔하임베트메디카게엠베하 칩 상에 다수의 측정 영역들을 제조하는 방법 및 다수의 측정 영역들을 갖는 칩
CN105908128B (zh) * 2016-04-21 2018-11-06 厦门建霖健康家居股份有限公司 一种光感应制备仿生疏水层的表面处理方法
EP3263216A1 (en) * 2016-06-27 2018-01-03 Magnomics, SA Sensing device and method
US11099157B2 (en) 2018-07-06 2021-08-24 Qorvo Biotechnologies, Llc Sensor with droplet retaining structure
CN109706066B (zh) * 2018-12-29 2022-08-26 赛纳生物科技(北京)有限公司 基因测序芯片微坑表面修饰方法
CN109813791B (zh) * 2019-01-02 2020-09-18 北京科技大学 一种基于微柱阵列的微液滴高通量电化学传感器
TWI873119B (zh) * 2019-01-29 2025-02-21 美商伊路米納有限公司 流通槽及製備其之方法
CN110174454A (zh) * 2019-06-18 2019-08-27 北京科技大学 一种微柱高通量的电化学传感器及其制备方法
CN113138186A (zh) * 2021-05-27 2021-07-20 福建师范大学 一种超疏水自动定位sers光谱检测平台及其制备方法和应用
CN114686992A (zh) * 2022-04-22 2022-07-01 赛润(上海)医学科技有限公司 亲疏水选择性修饰的高密度生物芯片制备方法及生物芯片
CN117153713B (zh) * 2023-10-25 2024-02-02 江苏惠达电子科技有限责任公司 频率元器件残留污染物的检测方法、系统和设备控制方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2617745B2 (ja) * 1987-12-02 1997-06-04 富士通株式会社 細微狭小領域への生体触媒の固定化方法
JP2778599B2 (ja) * 1990-01-23 1998-07-23 富士通株式会社 光不溶化性電解質組成物、これを使用するパターン形成方法、および電極素子の製法
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
DE69232419T2 (de) 1991-12-10 2002-09-19 The Dow Chemical Co., Midland Strahlungshärtbare cyclobutaren zusammensetzungen
GB9412789D0 (en) 1994-06-24 1994-08-17 Environmental Sensors Ltd Improvements to electrodes
EP0895083B1 (en) * 1997-08-01 2009-09-23 Canon Kabushiki Kaisha Reaction site array, preparation of it, reaction process using it and quantitative determination method of substance in sample solution using it
JP3610231B2 (ja) * 1997-08-01 2005-01-12 キヤノン株式会社 反応場アレー、反応場アレーの製造方法、反応場アレーを用いた反応方法及び反応場アレーを用いた試料溶液中の物質の定量方法
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
JP3829491B2 (ja) * 1998-08-27 2006-10-04 株式会社日立製作所 プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置
DE19916867A1 (de) 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Anordnung und Verfahren zur Herstellung planarer Arrays mit immobilisierten Molekülen
US6682649B1 (en) 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
JP2000297853A (ja) 2000-01-01 2000-10-24 Thk Co Ltd 直線案内装置及びその製造方法
CA2407973C (en) * 2000-05-03 2011-06-07 Jen-Jr Gau Biological identification system with integrated sensor chip
JP2001351116A (ja) * 2000-06-07 2001-12-21 Sony Corp 電子アニメコミック提供システム、電子情報作成装置、情報処理装置、記録媒体及び電子アニメコミック提供方法
US20040018615A1 (en) 2000-08-02 2004-01-29 Garyantes Tina K. Virtual wells for use in high throughput screening assays
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
JP2003014760A (ja) * 2001-04-27 2003-01-15 Canon Inc プローブ担体、プローブ固定用担体およびそれらの製造方法
FR2827386B1 (fr) * 2001-07-11 2003-10-31 Centre Nat Rech Scient Biopuce et son procede de fabrication
JP2003040112A (ja) 2001-07-30 2003-02-13 Tokai Rubber Ind Ltd ステアリング用ダイナミックダンパ装置
US6734436B2 (en) * 2001-08-07 2004-05-11 Sri International Optical microfluidic devices and methods
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
US20040058423A1 (en) * 2002-05-03 2004-03-25 Nancy Albritton Fast electrical lysis of cells and rapid collection of the contents thereof using capillary electrophoresis
WO2004027889A1 (ja) * 2002-09-19 2004-04-01 Daikin Industries, Ltd. パターン表面をテンプレートとして用いる材料とその製法
JP2004311957A (ja) * 2003-03-26 2004-11-04 Seiko Epson Corp デバイスとその製造方法及び電気光学装置並びに電子機器
WO2005002743A1 (en) * 2003-03-31 2005-01-13 Eidgenossische Technische Hochschule Zurich Controlled surface-chemical gradients
US20040241742A1 (en) * 2003-05-30 2004-12-02 Peck Bill J. Ligand array processing methods that include a low surface tension fluid deposition step and compositions for practicing the same
US6997018B2 (en) * 2003-06-02 2006-02-14 Ferro Corporation Method of micro and nano texturing glass
US20040258832A1 (en) * 2003-06-17 2004-12-23 Barklund Anna M. Method of chemical analysis using microwells patterned from self-assembled monolayers and substrates
US7699967B2 (en) * 2003-06-19 2010-04-20 Arkray, Inc. Analysis implement with opening in insulation film
SE0302074D0 (sv) * 2003-07-15 2003-07-15 Simon Ekstroem Device and method for analysis of samples using a combined sample treatment and sample carrier device
US20070207055A1 (en) * 2003-10-31 2007-09-06 Commissariat A L'energie Atomique Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest
KR100601954B1 (ko) * 2004-06-02 2006-07-14 삼성전자주식회사 패턴화된 유기실란층을 갖는 기판을 제조하는 방법 및상기 방법에 의하여 제조된 기판을 이용하는 방법
US7119035B2 (en) * 2004-11-22 2006-10-10 Taiwan Semiconductor Manufacturing Company, Ltd. Method using specific contact angle for immersion lithography
US8940143B2 (en) * 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
CN101578520B (zh) * 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
JP2011216647A (ja) * 2010-03-31 2011-10-27 Dainippon Printing Co Ltd パターン形成体の製造方法、機能性素子の製造方法および半導体素子の製造方法
DE102013210138A1 (de) 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen

Also Published As

Publication number Publication date
PL3004858T3 (pl) 2018-11-30
US10381277B2 (en) 2019-08-13
JP2016530484A (ja) 2016-09-29
JP6759314B2 (ja) 2020-09-23
CN110215940A (zh) 2019-09-10
EP3004858B1 (de) 2018-07-04
WO2014191114A2 (de) 2014-12-04
JP2019070657A (ja) 2019-05-09
BR112015029517B1 (pt) 2020-12-01
EP3004858A2 (de) 2016-04-13
CA2912151C (en) 2022-07-19
DE102013210138A1 (de) 2014-12-04
CN105408739B (zh) 2019-06-11
KR20160015296A (ko) 2016-02-12
WO2014191114A3 (de) 2015-01-22
BR112015029517A2 (pt) 2017-07-25
CA2912151A1 (en) 2014-12-04
US9735072B2 (en) 2017-08-15
DK3004858T3 (en) 2018-09-17
US20170301593A1 (en) 2017-10-19
JP6453316B2 (ja) 2019-01-16
CN105408739A (zh) 2016-03-16
BR122017011406B1 (pt) 2022-03-03
US20160126151A1 (en) 2016-05-05
BR122017011406A2 (pt) 2019-09-03

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