CN105408739B - 在芯片上制备多个测量区域的方法以及具有测量区域的芯片 - Google Patents

在芯片上制备多个测量区域的方法以及具有测量区域的芯片 Download PDF

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Publication number
CN105408739B
CN105408739B CN201480041722.XA CN201480041722A CN105408739B CN 105408739 B CN105408739 B CN 105408739B CN 201480041722 A CN201480041722 A CN 201480041722A CN 105408739 B CN105408739 B CN 105408739B
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chip
measured zone
layer
cell structure
hydrophobic
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Expired - Fee Related
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CN201480041722.XA
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English (en)
Chinese (zh)
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CN105408739A (zh
Inventor
M.希伯
H.舍德
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Boehringer Ingelheim Vetmedica GmbH
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Boehringer Ingelheim Vetmedica GmbH
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L22/00—Testing or measuring during manufacture or treatment; Reliability measurements, i.e. testing of parts without further processing to modify the parts as such; Structural arrangements therefor
    • H01L22/30—Structural arrangements specially adapted for testing or measuring during manufacture or treatment, or specially adapted for reliability measurements
    • H01L22/32—Additional lead-in metallisation on a device or substrate, e.g. additional pads or pad portions, lines in the scribe line, sacrificed conductors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D64/00—Electrodes of devices having potential barriers
    • H10D64/01—Manufacture or treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00635—Introduction of reactive groups to the surface by reactive plasma treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201480041722.XA 2013-05-30 2014-05-30 在芯片上制备多个测量区域的方法以及具有测量区域的芯片 Expired - Fee Related CN105408739B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910405331.6A CN110215940A (zh) 2013-05-30 2014-05-30 在芯片上制备多个测量区域的方法及具有测量区域的芯片

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102013210138.4 2013-05-30
DE102013210138.4A DE102013210138A1 (de) 2013-05-30 2013-05-30 Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
PCT/EP2014/001462 WO2014191114A2 (de) 2013-05-30 2014-05-30 Verfahren zum erzeugen einer vielzahl von messbereichen auf einem chip sowie chip mit messbereichen

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CN105408739A CN105408739A (zh) 2016-03-16
CN105408739B true CN105408739B (zh) 2019-06-11

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CN201910405331.6A Pending CN110215940A (zh) 2013-05-30 2014-05-30 在芯片上制备多个测量区域的方法及具有测量区域的芯片

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US (2) US9735072B2 (enExample)
EP (1) EP3004858B1 (enExample)
JP (2) JP6453316B2 (enExample)
KR (1) KR20160015296A (enExample)
CN (2) CN105408739B (enExample)
BR (2) BR122017011406B1 (enExample)
CA (1) CA2912151C (enExample)
DE (1) DE102013210138A1 (enExample)
DK (1) DK3004858T3 (enExample)
ES (1) ES2687949T3 (enExample)
PL (1) PL3004858T3 (enExample)
WO (1) WO2014191114A2 (enExample)

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DE102013210138A1 (de) 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
CA3003767A1 (en) * 2015-12-02 2017-06-08 Boehringer Ingelheim Vetmedica Gmbh Method for producing a plurality of measurement regions on a chip, and chip having a plurality of measurement regions
CN105908128B (zh) * 2016-04-21 2018-11-06 厦门建霖健康家居股份有限公司 一种光感应制备仿生疏水层的表面处理方法
EP3263216A1 (en) * 2016-06-27 2018-01-03 Magnomics, SA Sensing device and method
US11099157B2 (en) 2018-07-06 2021-08-24 Qorvo Biotechnologies, Llc Sensor with droplet retaining structure
CN109706066B (zh) * 2018-12-29 2022-08-26 赛纳生物科技(北京)有限公司 基因测序芯片微坑表面修饰方法
CN109813791B (zh) * 2019-01-02 2020-09-18 北京科技大学 一种基于微柱阵列的微液滴高通量电化学传感器
TWI873119B (zh) * 2019-01-29 2025-02-21 美商伊路米納有限公司 流通槽及製備其之方法
CN110174454A (zh) * 2019-06-18 2019-08-27 北京科技大学 一种微柱高通量的电化学传感器及其制备方法
CN113138186A (zh) * 2021-05-27 2021-07-20 福建师范大学 一种超疏水自动定位sers光谱检测平台及其制备方法和应用
CN114686992A (zh) * 2022-04-22 2022-07-01 赛润(上海)医学科技有限公司 亲疏水选择性修饰的高密度生物芯片制备方法及生物芯片
CN117153713B (zh) * 2023-10-25 2024-02-02 江苏惠达电子科技有限责任公司 频率元器件残留污染物的检测方法、系统和设备控制方法

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CA2912151C (en) 2022-07-19
BR112015029517B1 (pt) 2020-12-01
KR20160015296A (ko) 2016-02-12
EP3004858B1 (de) 2018-07-04
EP3004858A2 (de) 2016-04-13
US20160126151A1 (en) 2016-05-05
BR122017011406A2 (pt) 2019-09-03
JP6759314B2 (ja) 2020-09-23
JP2019070657A (ja) 2019-05-09
CA2912151A1 (en) 2014-12-04
JP2016530484A (ja) 2016-09-29
BR122017011406B1 (pt) 2022-03-03
CN110215940A (zh) 2019-09-10
PL3004858T3 (pl) 2018-11-30
DE102013210138A1 (de) 2014-12-04
WO2014191114A2 (de) 2014-12-04
WO2014191114A3 (de) 2015-01-22
BR112015029517A2 (pt) 2017-07-25
CN105408739A (zh) 2016-03-16
US20170301593A1 (en) 2017-10-19
ES2687949T3 (es) 2018-10-30
US9735072B2 (en) 2017-08-15
DK3004858T3 (en) 2018-09-17
JP6453316B2 (ja) 2019-01-16
US10381277B2 (en) 2019-08-13

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