ES2677619T3 - Análogos potentes de la compstatina - Google Patents

Análogos potentes de la compstatina Download PDF

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Publication number
ES2677619T3
ES2677619T3 ES11001292.9T ES11001292T ES2677619T3 ES 2677619 T3 ES2677619 T3 ES 2677619T3 ES 11001292 T ES11001292 T ES 11001292T ES 2677619 T3 ES2677619 T3 ES 2677619T3
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ES
Spain
Prior art keywords
trp
peptide
tryptophan
compound
sequence
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Active
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ES11001292.9T
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English (en)
Spanish (es)
Inventor
John D. Lambris
Madan Katragadda
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES11001292.9T 2005-11-28 2006-11-28 Análogos potentes de la compstatina Active ES2677619T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74020505P 2005-11-28 2005-11-28
US740205P 2005-11-28

Publications (1)

Publication Number Publication Date
ES2677619T3 true ES2677619T3 (es) 2018-08-03

Family

ID=37964706

Family Applications (3)

Application Number Title Priority Date Filing Date
ES11001293.7T Active ES2677947T3 (es) 2005-11-28 2006-11-28 Análogos potentes de la compstatina
ES06844589T Active ES2390828T3 (es) 2005-11-28 2006-11-28 Análogos potentes de la compstatina
ES11001292.9T Active ES2677619T3 (es) 2005-11-28 2006-11-28 Análogos potentes de la compstatina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES11001293.7T Active ES2677947T3 (es) 2005-11-28 2006-11-28 Análogos potentes de la compstatina
ES06844589T Active ES2390828T3 (es) 2005-11-28 2006-11-28 Análogos potentes de la compstatina

Country Status (15)

Country Link
US (5) US7888323B2 (enExample)
EP (4) EP2377878B1 (enExample)
JP (2) JP5302004B2 (enExample)
CN (3) CN102977191B (enExample)
BR (1) BRPI0619023B1 (enExample)
CA (2) CA2631443C (enExample)
DK (1) DK1960422T3 (enExample)
ES (3) ES2677947T3 (enExample)
HR (1) HRP20120621T1 (enExample)
IL (2) IL191674A (enExample)
PL (1) PL1960422T3 (enExample)
PT (1) PT1960422E (enExample)
RS (1) RS52429B (enExample)
RU (2) RU2474586C2 (enExample)
WO (1) WO2007062249A2 (enExample)

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US8637325B2 (en) * 2009-02-16 2014-01-28 University Of Wyoming Method and apparatus for pyrolysis-induced cleavage in peptides and proteins
WO2008048675A2 (en) * 2006-10-20 2008-04-24 Celldex Therapeutics, Inc. Treatment for age-related macular degeneration and other diseases of the eye
PL2148691T3 (pl) * 2007-02-05 2015-12-31 Apellis Pharmaceuticals Inc Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego
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WO2008153963A1 (en) * 2007-06-08 2008-12-18 The Trustees Of The University Of Pennsylvania Structure of compstatin-c3 complex and use for rational drug design
US8563259B2 (en) 2007-06-29 2013-10-22 The Trustees Of The University Of Pennsylvania Complement-mediated thrombophilic assay
CA2701470A1 (en) * 2007-10-02 2009-04-09 Potentia Pharmaceuticals, Inc. Sustained delivery of compstatin analogs from gels
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CA2738930C (en) * 2008-09-30 2021-08-17 The Trustees Of The University Of Pennsylvania Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors
WO2010127336A1 (en) * 2009-05-01 2010-11-04 The Trustees Of The University Of Pennsylvania Modified compstatin with peptide backbone and c-terminal modifications
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Also Published As

Publication number Publication date
DK1960422T3 (da) 2012-08-13
EP2377877A1 (en) 2011-10-19
US20190016758A1 (en) 2019-01-17
HK1124621A1 (en) 2009-07-17
US9169307B2 (en) 2015-10-27
CA2631443C (en) 2017-09-19
EP2377877B1 (en) 2018-03-28
CA2971349A1 (en) 2007-05-31
EP3363810A1 (en) 2018-08-22
JP5302004B2 (ja) 2013-10-02
CN101400692A (zh) 2009-04-01
RU2474586C2 (ru) 2013-02-10
WO2007062249A2 (en) 2007-05-31
IL191674A (en) 2015-04-30
JP2013177403A (ja) 2013-09-09
CN106188239B (zh) 2020-01-07
JP5927139B2 (ja) 2016-05-25
US20080227717A1 (en) 2008-09-18
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ES2390828T3 (es) 2012-11-16
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US20160096866A1 (en) 2016-04-07
US20170305971A1 (en) 2017-10-26
BRPI0619023A2 (pt) 2011-09-20
RU2008126232A (ru) 2010-01-10
CN102977191B (zh) 2016-08-10
CN102977191A (zh) 2013-03-20
WO2007062249A3 (en) 2007-09-13
EP1960422B1 (en) 2012-05-30
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RS52429B (sr) 2013-02-28
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CA2631443A1 (en) 2007-05-31
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US7888323B2 (en) 2011-02-15
RU2656102C2 (ru) 2018-05-31
RU2012147267A (ru) 2014-05-20
IL237915B (en) 2018-11-29
PT1960422E (pt) 2012-08-16
EP2377878B1 (en) 2018-03-28
HRP20120621T1 (hr) 2012-09-30
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US20120004393A1 (en) 2012-01-05

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