ES2675693T3 - Células progenitoras de linaje mesodérmico - Google Patents

Células progenitoras de linaje mesodérmico Download PDF

Info

Publication number
ES2675693T3
ES2675693T3 ES12735321.7T ES12735321T ES2675693T3 ES 2675693 T3 ES2675693 T3 ES 2675693T3 ES 12735321 T ES12735321 T ES 12735321T ES 2675693 T3 ES2675693 T3 ES 2675693T3
Authority
ES
Spain
Prior art keywords
cells
receptor
tissue
cell
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12735321.7T
Other languages
English (en)
Spanish (es)
Inventor
Thomas Averell HOUZE
Martin John Evans
Ajan Reginald
Ina Laura PIEPER
Brian Lee PERKINS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Therapy Ltd
Original Assignee
Cell Therapy Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1111509.4A external-priority patent/GB201111509D0/en
Priority claimed from GBGB1111500.3A external-priority patent/GB201111500D0/en
Priority claimed from GBGB1111503.7A external-priority patent/GB201111503D0/en
Priority claimed from GBGB1111505.2A external-priority patent/GB201111505D0/en
Application filed by Cell Therapy Ltd filed Critical Cell Therapy Ltd
Application granted granted Critical
Publication of ES2675693T3 publication Critical patent/ES2675693T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0665Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115Platelets, megakaryocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
ES12735321.7T 2011-07-06 2012-07-06 Células progenitoras de linaje mesodérmico Active ES2675693T3 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB201111505 2011-07-06
GBGB1111509.4A GB201111509D0 (en) 2011-07-06 2011-07-06 Orthopedic MSC subtype
GBGB1111500.3A GB201111500D0 (en) 2011-07-06 2011-07-06 Wet age-related macular degeneration MSC subtype
GB201111509 2011-07-06
GBGB1111503.7A GB201111503D0 (en) 2011-07-06 2011-07-06 Heart failure (HF) MSC subtype
GBGB1111505.2A GB201111505D0 (en) 2011-07-06 2011-07-06 MI MSC subtype
GB201111500 2011-07-06
GB201111503 2011-07-06
PCT/GB2012/051600 WO2013005053A2 (en) 2011-07-06 2012-07-06 Progenitor cells of mesodermal lineage

Publications (1)

Publication Number Publication Date
ES2675693T3 true ES2675693T3 (es) 2018-07-11

Family

ID=46513785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12735321.7T Active ES2675693T3 (es) 2011-07-06 2012-07-06 Células progenitoras de linaje mesodérmico

Country Status (19)

Country Link
US (3) US10472609B2 (https=)
EP (1) EP2729562B1 (https=)
JP (2) JP6607675B2 (https=)
CN (2) CN107746830A (https=)
AU (2) AU2012279995C1 (https=)
CA (1) CA2840307C (https=)
CY (1) CY1120646T1 (https=)
DK (1) DK2729562T3 (https=)
EA (1) EA029577B1 (https=)
ES (1) ES2675693T3 (https=)
HR (1) HRP20181152T1 (https=)
HU (1) HUE039236T2 (https=)
IL (2) IL230071B (https=)
LT (1) LT2729562T (https=)
MY (1) MY185016A (https=)
PL (1) PL2729562T3 (https=)
PT (1) PT2729562T (https=)
SG (1) SG10201605518XA (https=)
WO (1) WO2013005053A2 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
CN112569259A (zh) * 2011-11-23 2021-03-30 细胞治疗有限公司 血小板裂解物凝胶
EP3052943B1 (en) * 2013-10-04 2019-11-20 Cell Ideas Pty Ltd. Biomarkers for cell therapy
GB201408712D0 (en) * 2014-05-16 2014-07-02 Univ Leuven Kath Mesodermal progenitor cells
GB201410504D0 (en) * 2014-06-12 2014-07-30 Cell Therapy Ltd Immuno-modulaltory progenitor (IMP) cell
EP3186614A4 (en) * 2014-08-29 2018-03-21 Becton, Dickinson and Company Methods and compositions for obtaining a tuberculosis assessment in a subject
TWI723977B (zh) * 2015-02-20 2021-04-11 國立陽明大學 間質幹細胞於治療骨關節炎之用途
EP3091084A1 (en) * 2015-05-08 2016-11-09 Université Catholique De Louvain Methods for assessing the purity of a mesenchymal stem cells preparation
GB201513996D0 (en) * 2015-08-07 2015-09-23 Cell Therapy Ltd Immuno-oncology mesodermal progenitor (IOMP) cell
CA2998096C (en) 2015-09-11 2024-01-30 Astellas Pharma Inc. Method for producing renal progenitor cells
GB201518263D0 (en) 2015-10-15 2015-12-02 Oxford Bioelectronics Ltd Method
CN105483206B (zh) * 2016-01-06 2019-09-13 北京汉氏联合生物技术股份有限公司 一种用vcam-1检测msc促内皮细胞增殖能力的方法
JP7177041B2 (ja) * 2016-08-29 2022-11-22 ハッケンサック ユニヴァーシティ メディカル センター 血小板様細胞を含有する血液の血小板に富む画分を用いて成体細胞をプログラミングするための組成物および方法
KR20190039822A (ko) * 2016-08-29 2019-04-15 해컨색 유니버시티 메디컬 센터 인간에서 혈소판-유사 세포를 함유하는 혈액의 혈소판 풍부 분획의 줄기세포능을 통해 성체 세포를 재프로그래밍하기 위한 조성물 및 방법
CN119033819A (zh) 2017-11-22 2024-11-29 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
JP7009977B2 (ja) 2017-12-25 2022-01-26 国立大学法人東海国立大学機構 被検体の血中vegf-aに関する測定値を用いた心疾患の重症度及び予後予測を行うための方法、装置及びコンピュータプログラム
CN108715833B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种负载血小板裂解液的微球制备方法
CN108715834B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种富含cd41+、cd81+微囊的血小板裂解液制备方法
KR102928332B1 (ko) * 2018-11-14 2026-02-19 온데르조엑스- 엔 온트윅켈링즈폰즈 로데 크루이스-플란데렌 혈소판 방출물의 제조방법
CN109329270A (zh) * 2018-11-19 2019-02-15 成都清科生物科技有限公司 一种静脉回输用间充质干细胞保存液及其制备方法
JP7558952B2 (ja) * 2019-01-15 2024-10-01 セル セラピー リミテッド 中胚葉キラー(mk)細胞
GB201900554D0 (en) 2019-01-15 2019-03-06 Cell Therapy Ltd Mesodermal killer (mk) cell
US20220160776A1 (en) * 2019-01-28 2022-05-26 Mesoblast International Sárl Method for treating or preventing gastrointestinal bleeding
TW202110463A (zh) * 2019-05-15 2021-03-16 美商永生生技股份有限公司 高濃度細胞包裝和運送
CN110237094B (zh) * 2019-07-30 2023-10-03 天晴干细胞股份有限公司 一种底层血小板因子贴及sPL血小板因子凝胶贴膜的制备方法

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801537D0 (sv) 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
RU2138162C1 (ru) 1997-04-17 1999-09-27 Суханов Владимир Александрович Способ криоконсервации богатой тромбоцитами плазмы
CA2294944A1 (en) 1997-07-03 1999-01-14 Osiris Therapeutics, Inc. Human mesenchymal stem cells from peripheral blood
AU9127098A (en) 1997-09-04 1999-03-22 Osiris Therapeutics, Inc. Ligands that modulate differentiation of mesenchymal stem cells
PT1082410E (pt) 1998-05-29 2007-11-09 Osiris Therapeutics Inc Células estaminais mesenquimatosas humanas cd45+ e/ou fibroblastos+
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
EP2348104A1 (en) 1999-08-05 2011-07-27 Mcl Llc Multipotent adult stem cells and methods for isolation
JP2003055237A (ja) * 2001-08-15 2003-02-26 Japan Science & Technology Corp 骨再生促進剤
AUPR703601A0 (en) 2001-08-15 2001-09-06 Peter Maccallum Cancer Institute, The Identification and isolation of somatic stem cells and uses thereof
EP1483371B1 (en) 2002-02-19 2007-06-27 Medipost, Co., Ltd. Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues
KR100534215B1 (ko) 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
DE102005011568A1 (de) 2004-04-13 2005-11-17 Man Roland Druckmaschinen Ag Produktionsverfahren für eine Prägeeinrichtung in einer Bogendruckmaschine
US20090047257A1 (en) 2004-07-20 2009-02-19 Case Western Reserve University Novel cell populations and uses thereof
KR20070085288A (ko) 2004-09-24 2007-08-27 안지오블라스트 시스템스 인코퍼레이티드 간엽 전구세포의 증식 및/또는 생존성 증강 방법
CA2866468C (en) 2004-09-24 2019-09-03 Mesoblast, Inc. Generating multipotential expanded mesenchymal precursor cell progeny (memp) from mesenchymal progenitor cells (mpc) and stimulation factor
WO2006108229A1 (en) 2005-04-12 2006-10-19 Angioblast Systems, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
KR100679642B1 (ko) * 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
US20070258963A1 (en) 2006-01-13 2007-11-08 Osiris Therapeutics, Inc. Mesenchymal stem cells expressing TNF-alpha receptors
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
JP6041456B2 (ja) 2006-07-12 2016-12-07 メゾブラスト,インコーポレーテッド 過剰新生血管形成の治療
MY165114A (en) 2006-09-01 2018-02-28 Stempeutics Res Private Limited Self-renewing master adult pluripotent stem cells
WO2008097828A2 (en) 2007-02-02 2008-08-14 St. Jude Children's Research Hospital Method for isolating mesenchymal stromal cells
WO2008129563A2 (en) 2007-04-23 2008-10-30 Stempeutics Research Private Limited, Human mesenchymal stem cells and preparation thereof
US20090053182A1 (en) 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
US9095562B2 (en) * 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
EP2014294A1 (en) 2007-07-13 2009-01-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of CD200 as a mesenchymal stem cells marker
KR100970753B1 (ko) 2007-10-01 2010-07-16 재단법인서울대학교산학협력재단 광화능을 갖는 인간 치아 줄기세포 및 그의 배양방법
CA2692634C (en) 2007-11-09 2014-05-27 Rnl Bio Co., Ltd Method for isolating and culturing adult stem cells derived from human amniotic epithelium
KR101046188B1 (ko) * 2007-11-30 2011-07-04 주식회사 알앤엘바이오 탈락막 또는 지방 유래 줄기세포를 함유하는 요실금의 세포치료제
EP2297305A4 (en) 2008-05-15 2013-03-13 Univ Miami ISOLATION OF STEM CELL PROCESSORS AND EXPANSION UNDER NON-TERMS OF CONDITION
JP2011526892A (ja) 2008-06-30 2011-10-20 アンジオブラスト システムズ,インコーポレーテッド 併用療法を使用した眼疾患及び過剰血管新生の治療
EP2321408A4 (en) 2008-08-04 2013-04-17 Allocure Inc MESENCHYMAL STROMAZELL POPULATIONS AND PROCESS FOR THEIR INSULATION AND USE
EP2324359B1 (en) 2008-08-18 2018-10-31 Mesoblast, Inc. Use of heat shock protein 90-beta as marker for the identification and/or enrichment of adult multipotential mesenchymal precursor cells
JP5793724B2 (ja) * 2008-08-22 2015-10-14 公益財団法人ヒューマンサイエンス振興財団 脳梗塞治療材
ES2982461T3 (es) 2008-09-16 2024-10-16 Mayo Found Medical Education & Res Composiciones que contienen contenido plaquetario
EP2186883A1 (en) 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
EP2350266B1 (en) 2008-11-20 2015-07-29 Mesoblast, Inc. Method for treating or preventing a pancreatic dysfunction
JP5647230B2 (ja) 2009-04-28 2014-12-24 アントロジェン カンパニー リミテッドAnterogen Co., Ltd. 瘻孔治療のための自家及び同種異系の脂肪由来間質幹細胞組成物
US20120276067A1 (en) 2009-10-13 2012-11-01 Allocure, Inc. Assay for the Prediction of Therapeutic Effectiveness of Mesenchymal Stromal Cells, and Methods of Using Same
ES2358146B1 (es) 2009-10-22 2012-03-23 Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud En Sevilla Uso de células mesenquimales nestina positivas para el mantenimiento de la hematopoyesis.
US20120269779A1 (en) 2009-10-30 2012-10-25 Allocure, Inc. Mesenchymal stromal cell populations and methods of using same
CN102048756B (zh) 2009-11-04 2014-02-19 中国医学科学院基础医学研究所 人脂肪来源的间充质干细胞在肾脏、眼底疾病中的用途
WO2011068792A2 (en) 2009-12-01 2011-06-09 The Regents Of The University Of California Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
EP2506867B1 (en) * 2009-12-02 2014-10-08 Cardio3 Biosciences S.A. Pharmaceutical compositions for the stimulation of stem cells.
CA2803641A1 (en) 2010-07-02 2012-01-05 Mesoblast, Inc. Treatment of t-cell mediated immune disorders
EP2608797B1 (en) 2010-08-27 2015-09-23 University of Miami Bone marrow derived cd271 precursor cells for cardiac repair
US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
ES2384790B1 (es) 2010-12-10 2013-05-20 Instituto De Salud Carlos Iii Células madre mesenquimales aisladas a partir de sangre periférica.
US20120288480A1 (en) 2011-02-22 2012-11-15 Taipei Medical University Cell population comprising orbital fat-derived stem cells (ofscs) and their isolation and applications
CN102078644A (zh) * 2011-03-08 2011-06-01 吉林大学 一种简便高效的自体富血小板血浆提取装置及提取方法
KR101967492B1 (ko) 2011-05-19 2019-04-09 메소블라스트, 아이엔씨. 비만 및/또는 대사 증후군을 치료하는 방법
KR101920277B1 (ko) 2011-06-03 2018-11-20 메소블라스트, 아이엔씨. 뇌졸중 증상을 치료하는 방법
WO2012162754A1 (en) 2011-06-03 2012-12-06 Mesoblast, Inc Methods of treating or preventing neurological diseases
KR101786862B1 (ko) 2011-07-04 2017-10-18 메소블라스트, 아이엔씨. 류마티즘성 질환을 치료 또는 예방하는 방법
CA2847575C (en) 2011-09-09 2021-10-19 Mesoblast, Inc. Method for increasing osteoblastic function
HK1202581A1 (en) * 2012-02-13 2015-10-02 Gamida-Cell Ltd. Mesenchymal stem cells conditioned medium and methods of generating and using the same
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US20130273011A1 (en) 2012-04-17 2013-10-17 Medistem, Inc. Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome

Also Published As

Publication number Publication date
CN104508124B (zh) 2017-11-17
WO2013005053A2 (en) 2013-01-10
HRP20181152T1 (hr) 2018-09-21
JP2014520523A (ja) 2014-08-25
LT2729562T (lt) 2018-07-25
MY185016A (en) 2021-04-30
WO2013005053A3 (en) 2013-06-13
DK2729562T3 (en) 2018-07-23
EP2729562B1 (en) 2018-04-18
PL2729562T3 (pl) 2018-10-31
US10472609B2 (en) 2019-11-12
US20210032600A1 (en) 2021-02-04
IL264455A (en) 2019-02-28
CN107746830A (zh) 2018-03-02
US20150071886A1 (en) 2015-03-12
PT2729562T (pt) 2018-07-18
US10829739B2 (en) 2020-11-10
CY1120646T1 (el) 2019-12-11
EA201391773A1 (ru) 2014-11-28
AU2012279995A1 (en) 2014-01-23
AU2012279995C1 (en) 2019-10-24
EP2729562A2 (en) 2014-05-14
AU2017204559A1 (en) 2017-07-20
JP6607675B2 (ja) 2019-11-20
JP2017225451A (ja) 2017-12-28
AU2012279995B2 (en) 2017-03-30
CN104508124A (zh) 2015-04-08
CA2840307A1 (en) 2013-01-10
US11873513B2 (en) 2024-01-16
US20200048613A1 (en) 2020-02-13
EA029577B1 (ru) 2018-04-30
SG10201605518XA (en) 2016-08-30
HUE039236T2 (hu) 2018-12-28
CA2840307C (en) 2021-10-19
IL230071B (en) 2019-02-28
NZ620283A (en) 2016-06-24

Similar Documents

Publication Publication Date Title
ES2675693T3 (es) Células progenitoras de linaje mesodérmico
ES2963968T3 (es) Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas
JP6185657B2 (ja) 免疫調節前駆(imp)細胞
Marquez-Curtis et al. CXCR4 transfection of cord blood mesenchymal stromal cells with the use of cationic liposome enhances their migration toward stromal cell–derived factor-1
WO2009059032A2 (en) Uses and isolation of very small embryonic-like (vsel) stem cells
JP7668781B2 (ja) 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法
WO2005063967A1 (ja) 哺乳動物の骨髄細胞または臍帯血由来細胞と脂肪組織を利用した心筋細胞の誘導
WO2008085221A2 (en) Therapeutic use of cd31 expressing cells
EP3154599B1 (en) Hybrid composition
JP2021532776A (ja) 造血細胞の遺伝子改変のための方法
CN103182089A (zh) 用表达自杀基因的间充质干细胞进行细胞介导癌症基因治疗
WO2009152186A1 (en) Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors
HK1198047B (en) Progenitor cells of mesodermal lineage
HK1198047A (en) Progenitor cells of mesodermal lineage
NZ620283B2 (en) Progenitor cells of mesodermal lineage
KR20230133892A (ko) 골질환 치료용 의약 조성물
JP2011139691A (ja) 羊膜由来多能性幹細胞の製造方法