ES2657912T3 - Indolcarbonitrilos como moduladores selectivos de los receptores de andrógenos - Google Patents

Indolcarbonitrilos como moduladores selectivos de los receptores de andrógenos Download PDF

Info

Publication number
ES2657912T3
ES2657912T3 ES13758975.0T ES13758975T ES2657912T3 ES 2657912 T3 ES2657912 T3 ES 2657912T3 ES 13758975 T ES13758975 T ES 13758975T ES 2657912 T3 ES2657912 T3 ES 2657912T3
Authority
ES
Spain
Prior art keywords
methyl
compound
muscle
compounds
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13758975.0T
Other languages
English (en)
Spanish (es)
Inventor
Philip Stewart Turnbull
Rodolfo Cadilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property No 2 Ltd
Original Assignee
GlaxoSmithKline Intellectual Property No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49117887&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2657912(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GlaxoSmithKline Intellectual Property No 2 Ltd filed Critical GlaxoSmithKline Intellectual Property No 2 Ltd
Application granted granted Critical
Publication of ES2657912T3 publication Critical patent/ES2657912T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
ES13758975.0T 2012-07-17 2013-07-15 Indolcarbonitrilos como moduladores selectivos de los receptores de andrógenos Active ES2657912T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261672455P 2012-07-17 2012-07-17
US201261672455P 2012-07-17
US201361748874P 2013-01-04 2013-01-04
US201361748874P 2013-01-04
PCT/IB2013/001530 WO2014013309A1 (en) 2012-07-17 2013-07-15 Indolecarbonitriles as selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
ES2657912T3 true ES2657912T3 (es) 2018-03-07

Family

ID=49117887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13758975.0T Active ES2657912T3 (es) 2012-07-17 2013-07-15 Indolcarbonitrilos como moduladores selectivos de los receptores de andrógenos

Country Status (39)

Country Link
US (5) US8957104B2 (instruction)
EP (1) EP2875013B1 (instruction)
JP (1) JP6106746B2 (instruction)
KR (1) KR102127939B1 (instruction)
CN (1) CN104619693B (instruction)
AR (1) AR091770A1 (instruction)
AU (1) AU2013291721B2 (instruction)
BR (1) BR112015000940B1 (instruction)
CA (1) CA2879104C (instruction)
CL (1) CL2015000119A1 (instruction)
CO (1) CO7240378A2 (instruction)
CR (1) CR20150008A (instruction)
CY (1) CY1120064T1 (instruction)
DK (1) DK2875013T3 (instruction)
DO (1) DOP2015000004A (instruction)
EA (1) EA026371B8 (instruction)
ES (1) ES2657912T3 (instruction)
HR (1) HRP20180061T1 (instruction)
HU (1) HUE036238T2 (instruction)
IL (1) IL236448A (instruction)
IN (1) IN2014KN02993A (instruction)
JO (1) JO3384B1 (instruction)
LT (1) LT2875013T (instruction)
ME (1) ME02996B (instruction)
MX (1) MX349943B (instruction)
MY (2) MY173845A (instruction)
NZ (1) NZ703129A (instruction)
PE (1) PE20150371A1 (instruction)
PH (1) PH12015500104B1 (instruction)
PL (1) PL2875013T3 (instruction)
PT (1) PT2875013T (instruction)
RS (1) RS56810B1 (instruction)
SG (1) SG11201408493WA (instruction)
SI (1) SI2875013T1 (instruction)
SM (1) SMT201800115T1 (instruction)
TW (1) TWI574946B (instruction)
UY (1) UY34911A (instruction)
WO (1) WO2014013309A1 (instruction)
ZA (1) ZA201500096B (instruction)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155099B2 (en) 2009-09-21 2018-12-18 Cook Regentec Llc Method for infusing stem cells
CA2879104C (en) 2012-07-17 2020-08-25 Glaxosmithkline Intellectual Property (No.2) Limited Indolecarbonitriles as selective androgen receptor modulators
US9902694B2 (en) 2014-01-21 2018-02-27 GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED Crystalline forms
RU2691652C2 (ru) * 2014-10-16 2019-06-17 ДжиТиИкс, ИНК. Способы лечения урологических нарушений с применением селективных модуляторов андрогеновых рецепторов
CN105130872B (zh) * 2015-08-25 2018-01-30 江西师范大学 一种3位三氟甲基取代吲哚的制备方法
CN110437125B (zh) * 2019-09-06 2021-03-12 苏州旺山旺水生物医药有限公司 一种Tezacaftor中间体II的制备方法
WO2022204235A1 (en) * 2021-03-23 2022-09-29 Nido Biosciences, Inc. Bicyclic compounds as androgen receptor modulators
CN115010574B (zh) * 2022-06-06 2024-01-05 爱斯特（成都）生物制药股份有限公司 1-溴-2-氯-4-氟-2碘苯的合成方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504539A (ja) 1998-02-25 2002-02-12 ジェネティックス・インスチチュート・インコーポレーテッド ホスホリパーゼ酵素の阻害剤
WO1999065908A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
ES2471240T3 (es) 2002-05-24 2014-06-25 Bayer Cropscience Ag Procedimiento de preparación de derivados de tioalquilamina
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
CN1960973A (zh) * 2004-03-30 2007-05-09 惠氏公司 作为去甲肾上腺素(ne)与血清素(5－h t)活性和单胺重摄取的调控剂以治疗血管舒缩症状(vms)的1－(1h－吲哚－1－基)－3－(4－甲基哌嗪－1－基)－1－苯基丙烷－2－醇衍生物和相关化合物
CA2564952A1 (en) 2004-05-03 2005-11-24 Janssen Pharmaceutica N.V. Novel indole derivatives as selective androgen receptor modulators (sarms)
ATE525354T1 (de) 2004-05-03 2011-10-15 Janssen Pharmaceutica Nv Benzofuranderivate als selektive androgenrezeptormodulatoren (sarms)
JP5070041B2 (ja) 2004-05-03 2012-11-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドローゲン受容体モジュレーター（ｓａｒｍｓ）としての新規インドール化合物
ATE462692T1 (de) * 2004-06-01 2010-04-15 Hoffmann La Roche 3-amino-1-arylpropyl-indole als monoamin- wiederaufnahmehemmer
ES2377771T3 (es) * 2005-07-29 2012-03-30 Pfizer Products Inc. Derivados de pirrolo [2,3-d]pirimidina, sus intermedios y síntesis
GB0526246D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
BRPI0709612A2 (pt) 2006-03-15 2011-07-19 Wyeth Corp composto de fórmula i; método para o tratamento de um distúrbio no sistema nervoso central relacionado ou afetado pelo receptor histamina-3 em um paciente que necessita deste tratamento; método para a inibição do receptor h3; composição farmacêutica; e processo para a preparação de um composto de fórmula i
CN101426778A (zh) * 2006-03-15 2009-05-06 惠氏公司 作为组胺-3拮抗剂的n-经取代-氮杂环基胺
WO2008042571A2 (en) 2006-09-29 2008-04-10 Smithkline Beecham Corporation Substituted indole compounds
RU2493157C2 (ru) * 2008-08-20 2013-09-20 Пфайзер Инк. ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА
WO2010118287A1 (en) * 2009-04-10 2010-10-14 Radius Health, Inc. Selective androgen receptor modulators
EP2488524B1 (en) * 2009-10-15 2013-07-03 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine compounds
CA2782720A1 (en) * 2009-12-18 2011-06-23 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine compounds
CA2804161A1 (en) 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
JP6078004B2 (ja) * 2011-01-20 2017-02-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ミネラルコルチコイド受容体拮抗薬
ES2682755T3 (es) * 2011-12-21 2018-09-21 Jiangsu Hengrui Medicine Co. Ltd. Derivado del anillo heteroarilo de seis miembros de pirrol, método de preparación del mismo y sus usos medicinales
CA2879104C (en) 2012-07-17 2020-08-25 Glaxosmithkline Intellectual Property (No.2) Limited Indolecarbonitriles as selective androgen receptor modulators
US9902694B2 (en) * 2014-01-21 2018-02-27 GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED Crystalline forms

Also Published As

Publication number Publication date
CN104619693A (zh) 2015-05-13
CR20150008A (es) 2015-03-09
SG11201408493WA (en) 2015-02-27
MX2015000825A (es) 2015-07-17
PT2875013T (pt) 2018-02-28
DK2875013T3 (en) 2018-01-22
EP2875013A1 (en) 2015-05-27
WO2014013309A1 (en) 2014-01-23
LT2875013T (lt) 2018-02-26
KR20150032333A (ko) 2015-03-25
JP2015522603A (ja) 2015-08-06
EA201492237A1 (ru) 2015-06-30
US11299457B2 (en) 2022-04-12
IL236448A0 (en) 2015-02-26
US20200270210A1 (en) 2020-08-27
HK1208867A1 (en) 2016-03-18
SMT201800115T1 (it) 2018-03-08
CY1120064T1 (el) 2018-12-12
PE20150371A1 (es) 2015-03-27
US20140024694A1 (en) 2014-01-23
HUE036238T2 (hu) 2018-06-28
JP6106746B2 (ja) 2017-04-05
PH12015500104A1 (en) 2015-03-02
CL2015000119A1 (es) 2015-04-24
KR102127939B1 (ko) 2020-06-29
JO3384B1 (ar) 2019-03-13
US20190127326A1 (en) 2019-05-02
RS56810B1 (sr) 2018-04-30
CO7240378A2 (es) 2015-04-17
CN104619693B (zh) 2019-08-13
HRP20180061T1 (hr) 2018-02-23
BR112015000940A2 (pt) 2017-06-27
AR091770A1 (es) 2015-02-25
NZ703129A (en) 2017-06-30
TW201416349A (zh) 2014-05-01
US10196353B2 (en) 2019-02-05
MY173845A (en) 2020-02-24
MX349943B (es) 2017-08-21
CA2879104C (en) 2020-08-25
US20150080449A1 (en) 2015-03-19
IL236448A (en) 2016-10-31
IN2014KN02993A (instruction) 2015-05-08
EA026371B1 (ru) 2017-03-31
AU2013291721A1 (en) 2015-02-26
TWI574946B (zh) 2017-03-21
DOP2015000004A (es) 2015-03-15
ME02996B (me) 2018-10-20
ZA201500096B (en) 2017-07-26
PH12015500104B1 (en) 2015-03-02
UY34911A (es) 2014-02-28
US20170073309A1 (en) 2017-03-16
EP2875013B1 (en) 2017-11-29
CA2879104A1 (en) 2014-01-23
BR112015000940B1 (pt) 2022-05-17
US8957104B2 (en) 2015-02-17
EA026371B8 (ru) 2017-06-30
PL2875013T3 (pl) 2018-06-29
SI2875013T1 (en) 2018-03-30
US9533948B2 (en) 2017-01-03
AU2013291721B2 (en) 2016-02-25
MY198512A (en) 2023-09-01
US10710963B2 (en) 2020-07-14

Similar Documents

Publication Publication Date Title
ES2657912T3 (es) Indolcarbonitrilos como moduladores selectivos de los receptores de andrógenos
WO2004110978A2 (en) 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors
JP2007500245A (ja) 化合物
JP2002502422A (ja) ゴナドトロピン放出ホルモンの拮抗薬
US11001556B2 (en) Crystalline forms
HK1208867B (en) Indolecarbonitriles as selective androgen receptor modulators
UA112898C2 (uk) Індолкарбонітрили як селективні модулятори андрогенного рецептора